ERRs Mediate a Metabolic Switch Required for Somatic Cell Reprogramming to Pluripotency

• Published in: Cell stem cell Vol. 16; no. 5; pp. 547 - 555
• Main Authors: Kida, Yasuyuki S., Kawamura, Teruhisa, Wei, Zong, Sogo, Takahiro, Jacinto, Sandra, Shigeno, Asako, Kushige, Hiroko, Yoshihara, Eiji, Liddle, Christopher, Ecker, Joseph R., Yu, Ruth T., Atkins, Annette R., Downes, Michael, Evans, Ronald M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.05.2015
• Subjects: Adult Stem Cells - physiology; Animals; Antigens, CD34 - metabolism; Ataxin-1 - metabolism; Cell Line; Cellular Reprogramming; ERRalpha Estrogen-Related Receptor; Humans; Mice; Mice, Knockout; Oxidative Phosphorylation; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Pluripotent Stem Cells - physiology; Receptors, Estrogen - genetics; Receptors, Estrogen - metabolism; Transcription Factors - metabolism

Cell metabolism is adaptive to extrinsic demands; however, the intrinsic metabolic demands that drive the induced pluripotent stem cell (iPSC) program remain unclear. Although glycolysis increases throughout the reprogramming process, we show that the estrogen-related nuclear receptors (ERRα and ERR...