Association between insomnia and cognitive performance, gray matter volume, and white matter microstructure in cognitively unimpaired adults

• Published in: Alzheimer's research & therapy Vol. 12; no. 1; p. 4
• Main Authors: Grau-Rivera, Oriol, Operto, Grégory, Falcón, Carles, Sánchez-Benavides, Gonzalo, Cacciaglia, Raffaele, Brugulat-Serrat, Anna, Gramunt, Nina, Salvadó, Gemma, Suárez-Calvet, Marc, Minguillon, Carolina, Iranzo, Álex, Gispert, Juan Domingo, Molinuevo, José Luis
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07.01.2020; BioMed Central; BMC
• Subjects: Adults; Advertising executives; Alzheimer disease; Alzheimer's disease; Anxiety; Apolipoprotein E4 - genetics; Apolipoproteins; Brain; Brain - pathology; Cognition & reasoning; Cognition - physiology; Cognitive ability; Cross-Sectional Studies; Dementia; Family medical history; Female; Genotype & phenotype; Gray Matter - pathology; Health; Health surveys; Heterozygote; Humans; Inflammation; Insomnia; Insomniacs; Magnetic Resonance Imaging; Male; Medical imaging; Memory; Mental depression; Mental health; Middle Aged; Neurocognitive disorders; Neuropsychology; Public health; Quality; Sleep; Sleep Initiation and Maintenance Disorders - genetics; Sleep Initiation and Maintenance Disorders - pathology; Surveys; White Matter - pathology; Diffusion-weighted imaging; Sleep; Magnetic resonance imaging; Neurocognitive disorders; Alzheimer disease; Insomnia; Voxel-based morphometry; Inflammation; Neuropsychology

Mounting evidence links poor sleep quality with a higher risk of late-life dementia. However, the structural and cognitive correlates of insomnia are still not well understood. The study aims were to characterize the cognitive performance and brain structural pattern of cognitively unimpaired adults...