Dkk‐3 is elevated in CSF and plasma of Alzheimer’s disease patients

• Published in: Journal of neurochemistry Vol. 110; no. 2; pp. 653 - 661
• Main Authors: Zenzmaier, Christoph, Marksteiner, Josef, Kiefer, Andreas, Berger, Peter, Humpel, Christian
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2009; Wiley-Blackwell
• Subjects: Adaptor Proteins, Signal Transducing; Adult; Adult and adolescent clinical studies; Aged; Aged, 80 and over; Alzheimer disease; Alzheimer Disease - blood; Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - diagnosis; Alzheimer's disease; Amino Acid Sequence; Biological and medical sciences; Biomarkers; Biomarkers - blood; Biomarkers - cerebrospinal fluid; biosynthesis; blood; Brain; Brain - metabolism; Brain - pathology; Cellular Senescence; Cellular Senescence - physiology; cerebrospinal fluid; Chemokines; Cognition Disorders; Cognition Disorders - blood; Cognition Disorders - cerebrospinal fluid; Cognition Disorders - diagnosis; CSF; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Depression; Depression - blood; Depression - cerebrospinal fluid; Depression - diagnosis; diagnosis; Dickkopf‐3; Humans; Intercellular Signaling Peptides and Proteins; Intercellular Signaling Peptides and Proteins - biosynthesis; Intercellular Signaling Peptides and Proteins - blood; Intercellular Signaling Peptides and Proteins - cerebrospinal fluid; Intercellular Signaling Peptides and Proteins - isolation & purification; isolation & purification; Male; Medical diagnosis; Medical sciences; metabolism; Middle Aged; Molecular biology; Molecular Sequence Data; Neurology; Neurosciences; Organic mental disorders. Neuropsychology; pathology; physiology; Plasma; Proteins; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; p‐tau‐181; tau; β‐amyloid (1–42); Mood disorder; Choroid plexus; Ependymal organ; β-amyloid (1―42); Nervous system diseases; Cognitive disorder; Dickkopf-3; Alzheimer disease; Central nervous system; Glycoprotein; Depression; tau; p-tau-181; Cerebral disorder; Accuracy; Neuron; Central nervous system disease; CSF; Epithelial cell; Tumor; Degenerative disease; mild cognitive impairment; Mass spectrometry; Alzheimer's disease

Biomarkers in CSF can offer improved diagnostic accuracy for Alzheimer’s disease (AD). The present study investigated whether the glycoprotein and putative tumor suppressor Dickkopf homolog 3 (Dkk‐3) is secreted into CSF and evaluated its applicability as a diagnostic marker for AD. Using our highly...