Voltage-dependent calcium and potassium channels in Schwann cells cultured from dorsal root ganglia of the mouse

• Published in: The Journal of physiology Vol. 441; no. 1; pp. 35 - 56
• Main Authors: Amédée, T, Ellie, E, Dupouy, B, Vincent, J D
• Format: Journal Article
• Language: English
• Published: Oxford The Physiological Society 01.09.1991; Blackwell
• Subjects: 4-Aminopyridine - pharmacology; Animals; Barium - metabolism; Biological and medical sciences; Calcium Channels - drug effects; Calcium Channels - physiology; Cells, Cultured; Cobalt - pharmacology; dorsal root ganglia; Dose-Response Relationship, Drug; Fundamental and applied biological sciences. Psychology; Ganglia, Spinal - cytology; Isolated neuron and nerve. Neuroglia; Membrane Potentials - drug effects; Mice; Nifedipine - pharmacology; potassium; Potassium Channels - drug effects; Potassium Channels - physiology; Schwann cells; Schwann Cells - physiology; Tetraethylammonium; Tetraethylammonium Compounds - pharmacology; Tetrodotoxin - pharmacology; Vertebrates: nervous system and sense organs; Peripheral nervous system; Cell culture; Calcium; Rodentia; Electrophysiology; Patch clamp method; Ionic channel; Neuroglía; Vertebrata; Mammalia; Mouse; Schwann cell; Spinal ganglion; Membrane potential; Potassium

1. Whole-cell patch clamp studies were carried out on Schwann cells in organotypic cultures of dorsal root ganglia (DRG) from OF1 mice embryos (18-19 days). 2. In standard external solution, from a holding potential of -70 mV, two types of voltage-dependent K+ currents were recorded: a fast transien...