Mice lacking histidine decarboxylase exhibit abnormal mast cells

Histidine decarboxylase (HDC) synthesizes histamine from histidine in mammals. To evaluate the role of histamine, we generated HDC-deficient mice using a gene targeting method. The mice showed a histamine deficiency and lacked histamine-synthesizing activity from histidine. These HDC-deficient mice...

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Published in	FEBS letters Vol. 502; no. 1; pp. 53 - 56
Main Authors	Ohtsu, Hiroshi, Tanaka, Satoshi, Terui, Tadashi, Hori, Yoshio, Makabe-Kobayashi, Yoko, Pejler, Gunnar, Tchougounova, Elena, Hellman, Lars, Gertsenstein, Marina, Hirasawa, Noriyasu, Sakurai, Eiko, Buzás, Edit, Kovács, Péter, Csaba, György, Kittel, Ágnes, Okada, Mikiko, Hara, Masahiro, Mar, Lynn, Numayama-Tsuruta, Keiko, Ishigaki-Suzuki, Satsuki, Ohuchi, Kazuo, Ichikawa, Atsushi, Falus, András, Watanabe, Takehiko, Nagy, András
Format	Journal Article
Language	English
Published	England Elsevier B.V 27.07.2001
Subjects	Alleles Animals BMMC, bone marrow-derived mast cell HDC, histidine decarboxylase Histamine Histamine - biosynthesis Histamine - metabolism Histidine Decarboxylase - genetics Histidine Decarboxylase - physiology Knockout Mast cell Mast Cells - cytology MC-CPA, mast cell carboxypeptidase A Mice Mice, Knockout MMCP, mouse mast cell protease Rodent α-FMH, α-fluoromethyl histidine MC-CPA, mast cell carboxypeptidase A Histamine α-FMH, α-fluoromethyl histidine Mast cell HDC, histidine decarboxylase MMCP, mouse mast cell protease Rodent BMMC, bone marrow-derived mast cell Knockout
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Abstract	Histidine decarboxylase (HDC) synthesizes histamine from histidine in mammals. To evaluate the role of histamine, we generated HDC-deficient mice using a gene targeting method. The mice showed a histamine deficiency and lacked histamine-synthesizing activity from histidine. These HDC-deficient mice are viable and fertile but exhibit a decrease in the numbers of mast cells while the remaining mast cells show an altered morphology and reduced granular content. The amounts of mast cell granular proteases were tremendously reduced. The HDC-deficient mice provide a unique and promising model for studying the role of histamine in a broad range of normal and disease processes.
AbstractList	Histidine decarboxylase (HDC) synthesizes histamine from histidine in mammals. To evaluate the role of histamine, we generated HDC‐deficient mice using a gene targeting method. The mice showed a histamine deficiency and lacked histamine‐synthesizing activity from histidine. These HDC‐deficient mice are viable and fertile but exhibit a decrease in the numbers of mast cells while the remaining mast cells show an altered morphology and reduced granular content. The amounts of mast cell granular proteases were tremendously reduced. The HDC‐deficient mice provide a unique and promising model for studying the role of histamine in a broad range of normal and disease processes.
Author	Falus, András Buzás, Edit Gertsenstein, Marina Ishigaki-Suzuki, Satsuki Ohuchi, Kazuo Kovács, Péter Csaba, György Ohtsu, Hiroshi Hara, Masahiro Hori, Yoshio Nagy, András Tanaka, Satoshi Okada, Mikiko Numayama-Tsuruta, Keiko Terui, Tadashi Hellman, Lars Hirasawa, Noriyasu Watanabe, Takehiko Pejler, Gunnar Makabe-Kobayashi, Yoko Mar, Lynn Ichikawa, Atsushi Kittel, Ágnes Sakurai, Eiko Tchougounova, Elena
Author_xml	– sequence: 1 givenname: Hiroshi surname: Ohtsu fullname: Ohtsu, Hiroshi email: ohtsu@mail.cc.tohoku.ac.jp organization: Department of Cellular Pharmacology, Tohoku University School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan – sequence: 2 givenname: Satoshi surname: Tanaka fullname: Tanaka, Satoshi organization: Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan – sequence: 3 givenname: Tadashi surname: Terui fullname: Terui, Tadashi organization: Department of Dermatology, Tohoku University School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan – sequence: 4 givenname: Yoshio surname: Hori fullname: Hori, Yoshio organization: Department of Cellular Pharmacology, Tohoku University School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan – sequence: 5 givenname: Yoko surname: Makabe-Kobayashi fullname: Makabe-Kobayashi, Yoko organization: Department of Cellular Pharmacology, Tohoku University School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan – sequence: 6 givenname: Gunnar surname: Pejler fullname: Pejler, Gunnar organization: Department of Veterinary Medical Chemistry, Swedish University of Agricultural Sciences, BMC, P.O. Box 575, 751 23 Uppsala, Sweden – sequence: 7 givenname: Elena surname: Tchougounova fullname: Tchougounova, Elena organization: Department of Veterinary Medical Chemistry, Swedish University of Agricultural Sciences, BMC, P.O. Box 575, 751 23 Uppsala, Sweden – sequence: 8 givenname: Lars surname: Hellman fullname: Hellman, Lars organization: Department of Veterinary Medical Chemistry, Swedish University of Agricultural Sciences, BMC, P.O. Box 575, 751 23 Uppsala, Sweden – sequence: 9 givenname: Marina surname: Gertsenstein fullname: Gertsenstein, Marina organization: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5 – sequence: 10 givenname: Noriyasu surname: Hirasawa fullname: Hirasawa, Noriyasu organization: Department of Pathophysiological Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan – sequence: 11 givenname: Eiko surname: Sakurai fullname: Sakurai, Eiko organization: Department of Cellular Pharmacology, Tohoku University School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan – sequence: 12 givenname: Edit surname: Buzás fullname: Buzás, Edit organization: Department of Genetics, Cell- and Immunobiology, Semmelweis Medical University, 4 Nagyvárad tér, H-1089 Budapest, Hungary – sequence: 13 givenname: Péter surname: Kovács fullname: Kovács, Péter organization: Department of Genetics, Cell- and Immunobiology, Semmelweis Medical University, 4 Nagyvárad tér, H-1089 Budapest, Hungary – sequence: 14 givenname: György surname: Csaba fullname: Csaba, György organization: Department of Genetics, Cell- and Immunobiology, Semmelweis Medical University, 4 Nagyvárad tér, H-1089 Budapest, Hungary – sequence: 15 givenname: Ágnes surname: Kittel fullname: Kittel, Ágnes organization: Institute of Experimental Medicine, Budapest, Hungary – sequence: 16 givenname: Mikiko surname: Okada fullname: Okada, Mikiko organization: Department of Dermatology, Tohoku University School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan – sequence: 17 givenname: Masahiro surname: Hara fullname: Hara, Masahiro organization: Department of Dermatology, Tohoku University School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan – sequence: 18 givenname: Lynn surname: Mar fullname: Mar, Lynn organization: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5 – sequence: 19 givenname: Keiko surname: Numayama-Tsuruta fullname: Numayama-Tsuruta, Keiko organization: Department of Cellular Pharmacology, Tohoku University School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan – sequence: 20 givenname: Satsuki surname: Ishigaki-Suzuki fullname: Ishigaki-Suzuki, Satsuki organization: Department of Cellular Pharmacology, Tohoku University School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan – sequence: 21 givenname: Kazuo surname: Ohuchi fullname: Ohuchi, Kazuo organization: Department of Pathophysiological Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan – sequence: 22 givenname: Atsushi surname: Ichikawa fullname: Ichikawa, Atsushi organization: Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan – sequence: 23 givenname: András surname: Falus fullname: Falus, András organization: Department of Genetics, Cell- and Immunobiology, Semmelweis Medical University, 4 Nagyvárad tér, H-1089 Budapest, Hungary – sequence: 24 givenname: Takehiko surname: Watanabe fullname: Watanabe, Takehiko organization: Department of Cellular Pharmacology, Tohoku University School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan – sequence: 25 givenname: András surname: Nagy fullname: Nagy, András email: nagy@mshri.on.ca organization: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5
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Copyright	2001 Federation of European Biochemical Societies FEBS Letters 502 (2001) 1873-3468 © 2015 Federation of European Biochemical Societies
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Keywords	MC-CPA, mast cell carboxypeptidase A Histamine α-FMH, α-fluoromethyl histidine Mast cell HDC, histidine decarboxylase MMCP, mouse mast cell protease Rodent BMMC, bone marrow-derived mast cell Knockout
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Snippet	Histidine decarboxylase (HDC) synthesizes histamine from histidine in mammals. To evaluate the role of histamine, we generated HDC-deficient mice using a gene... Histidine decarboxylase (HDC) synthesizes histamine from histidine in mammals. To evaluate the role of histamine, we generated HDC‐deficient mice using a gene...
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SubjectTerms	Alleles Animals BMMC, bone marrow-derived mast cell HDC, histidine decarboxylase Histamine Histamine - biosynthesis Histamine - metabolism Histidine Decarboxylase - genetics Histidine Decarboxylase - physiology Knockout Mast cell Mast Cells - cytology MC-CPA, mast cell carboxypeptidase A Mice Mice, Knockout MMCP, mouse mast cell protease Rodent α-FMH, α-fluoromethyl histidine
Title	Mice lacking histidine decarboxylase exhibit abnormal mast cells
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