西酞普兰合并改良电休克治疗对抑郁发作的疗效及认知功能的影响
目的比较西酞普兰合并改良电休克治疗（MECT）与西酞普兰单一治疗抑郁发作的效果以及对认知功能的影响。方法采取临床试验研究,收集符合《国际疾病分类第（10版）》（ICD-10）抑郁发作诊断标准的患者80例,随机分为西酞普兰合并MECT组及西酞普兰单药组各40例。合并MECT治疗组需进行为期2周、共8次MECT治疗。两组均经过为期4周的治疗。在MECT治疗前及治疗2、4周末采用汉密尔顿抑郁量表（HRSD）和威斯康星卡片分类测验（WCST）对两组疗效及认知损害进行测评。结果治疗前两组HRSD评分比较差异无统计学意义（t=0.51,P〉0.05）。治疗2周末两组间HRSD评分差异有统计学意义（t=2....
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| Published in | 四川精神卫生 Vol. 28; no. 2; pp. 123 - 126 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
100096,北京回龙观医院
2015
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1007-3256 |
| DOI | 10.11886/j.issn.1007-3256.2015.02.009 |
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| Abstract | 目的比较西酞普兰合并改良电休克治疗（MECT）与西酞普兰单一治疗抑郁发作的效果以及对认知功能的影响。方法采取临床试验研究,收集符合《国际疾病分类第（10版）》（ICD-10）抑郁发作诊断标准的患者80例,随机分为西酞普兰合并MECT组及西酞普兰单药组各40例。合并MECT治疗组需进行为期2周、共8次MECT治疗。两组均经过为期4周的治疗。在MECT治疗前及治疗2、4周末采用汉密尔顿抑郁量表（HRSD）和威斯康星卡片分类测验（WCST）对两组疗效及认知损害进行测评。结果治疗前两组HRSD评分比较差异无统计学意义（t=0.51,P〉0.05）。治疗2周末两组间HRSD评分差异有统计学意义（t=2.66,P〈0.05）;疗程结束时两组HRSD评分差异无统计学意义（t=1.81,P〉0.05）。合并MECT组中WCST中的总应答数（ra）、完成分类（cc）、错误应答数（re）、概念化（rf%）、非持续错误（nrpe）及学习到学会（l-l%）等项在治疗2周后较治疗前差（P〈0.05）;在治疗4周后较治疗前好（P〈0.05）;其它各指标治疗前后差异均无统计学意义（P均〉0.05）。结论西酞普兰合并MECT治疗较西酞普兰单药能更快起效,而且持续疗效稳定。合并MECT治疗患者可出现短期、可逆的认知功能损害,但提示远期预后较好。 |
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| AbstractList | R749.4; 目的：比较西酞普兰合并改良电休克治疗（ MECT）与西酞普兰单一治疗抑郁发作的效果以及对认知功能的影响。方法采取临床试验研究，收集符合《国际疾病分类第（10版）》（ICD -10）抑郁发作诊断标准的患者80例，随机分为西酞普兰合并 MECT 组及西酞普兰单药组各40例。合并 MECT 治疗组需进行为期2周、共8次MECT 治疗。两组均经过为期4周的治疗。在 MECT 治疗前及治疗2、4周末采用汉密尔顿抑郁量表（HRSD）和威斯康星卡片分类测验（WCST）对两组疗效及认知损害进行测评。结果治疗前两组 HRSD 评分比较差异无统计学意义（t =0.51，P ﹥0.05）。治疗2周末两组间 HRSD 评分差异有统计学意义（t =2.66，P <0.05）；疗程结束时两组HRSD 评分差异无统计学意义（t =1.81，P ﹥0.05）。合并 MECT 组中 WCST 中的总应答数（ra）、完成分类（cc）、错误应答数（re）、概念化（rf%）、非持续错误（nrpe）及学习到学会（l - l%）等项在治疗2周后较治疗前差（P <0.05）；在治疗4周后较治疗前好（P <0.05）；其它各指标治疗前后差异均无统计学意义（P 均﹥0.05）。结论西酞普兰合并 MECT 治疗较西酞普兰单药能更快起效，而且持续疗效稳定。合并 MECT 治疗患者可出现短期、可逆的认知功能损害，但提示远期预后较好。 目的比较西酞普兰合并改良电休克治疗（MECT）与西酞普兰单一治疗抑郁发作的效果以及对认知功能的影响。方法采取临床试验研究,收集符合《国际疾病分类第（10版）》（ICD-10）抑郁发作诊断标准的患者80例,随机分为西酞普兰合并MECT组及西酞普兰单药组各40例。合并MECT治疗组需进行为期2周、共8次MECT治疗。两组均经过为期4周的治疗。在MECT治疗前及治疗2、4周末采用汉密尔顿抑郁量表（HRSD）和威斯康星卡片分类测验（WCST）对两组疗效及认知损害进行测评。结果治疗前两组HRSD评分比较差异无统计学意义（t=0.51,P〉0.05）。治疗2周末两组间HRSD评分差异有统计学意义（t=2.66,P〈0.05）;疗程结束时两组HRSD评分差异无统计学意义（t=1.81,P〉0.05）。合并MECT组中WCST中的总应答数（ra）、完成分类（cc）、错误应答数（re）、概念化（rf%）、非持续错误（nrpe）及学习到学会（l-l%）等项在治疗2周后较治疗前差（P〈0.05）;在治疗4周后较治疗前好（P〈0.05）;其它各指标治疗前后差异均无统计学意义（P均〉0.05）。结论西酞普兰合并MECT治疗较西酞普兰单药能更快起效,而且持续疗效稳定。合并MECT治疗患者可出现短期、可逆的认知功能损害,但提示远期预后较好。 |
| Abstract_FL | Objective To compare the clinical response and cognitive dysfunction of depressive inpatients treated with citapramil complicated with modified electro - convulsive therapy(MECT)and citapramil only. Methods According the clinical trial,80 inpa-tients matched with the criteria of International Classification of Diseases tenth edition(ICD - 10)about depressive disorder were en-rolled,and divided randomly into both groups of citapramil complicated with MECT and citapramil only. After 8 times treatment of MECT and totally 4 - week treatment,the response and cognitive dysfunction were compared at pre - and post - treatment of MECT for 2 weeks and 4 weeks separately between the two groups with Hamilton Rating Scale for Depression(HRSD)and Wisconsin Card Sor-ting Test(WCST). Results At the baseline,the scores of HRSD were not different between both of groups(t = 0. 51,P ﹥ 0. 05). There was statistics difference between both of groups after 2 - week treatment(t = 2. 66,P < 0. 05). In the group of complicated with MECT,scores of ra,cc,re,rf% ,nrpe,and l - l% in WCST were decreased significantly after 2 - week treatment,but improved af-ter 4 - week treatment and better than the baseline(t = 1. 81,P ﹥ 0. 05). Other items do not show the differences(P ﹥ 0. 05). Con-clusion Citapramil with MECT can obtain the effects of treatment faster than with citapramil only,moreover,the effects can be main-tained. The patients complicated with MECT will have a short - term,and reversible cognitive dysfunction. |
| Author | 牛亚杰 杨少杰 杨可冰 李伟 冀成君 |
| AuthorAffiliation | 北京回龙观医院,100096 |
| AuthorAffiliation_xml | – name: 100096,北京回龙观医院 |
| Author_FL | JI Cheng-jun NIU Ya-jie LI Wei YANG Ke-bing YANG Shao-jie |
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| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
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| Keywords | Response 改良电休克治疗 抑郁发作 Modified Electroconvulsive Therapy 认知功能 Cognitive dysfunction 疗效 Depressive disorder |
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| Notes | 51-1457/R Modified Electroconvulsive Therapy;Depressive disorder;Response;Cognitive dysfunction Objective To compare the clinical response and cognitive dysfunction of depressive inpatients treated with citapramil complicated with modified electro - convulsive therapy（MECT）and citapramil only. Methods According the clinical trial,80 inpa-tients matched with the criteria of International Classification of Diseases tenth edition（ICD - 10）about depressive disorder were en-rolled,and divided randomly into both groups of citapramil complicated with MECT and citapramil only. After 8 times treatment of MECT and totally 4 - week treatment,the response and cognitive dysfunction were compared at pre - and post - treatment of MECT for 2 weeks and 4 weeks separately between the two groups with Hamilton Rating Scale for Depression（HRSD）and Wisconsin Card Sor-ting Test（WCST）. Results At the baseline,the scores of HRSD were not different between both of groups（t = 0. 51,P ﹥ 0. 05）. There was statistics difference between both |
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| SubjectTerms | 抑郁发作 改良电休克治疗 疗效 认知功能 |
| Title | 西酞普兰合并改良电休克治疗对抑郁发作的疗效及认知功能的影响 |
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