VEGF-C和VEGF-R3在乳腺癌中的表达及与淋巴结转移的关系

R737.9; 目的探讨VEGF-C及其受体VEGF-R3在乳腺导管癌中的表达及与淋巴结转移等临床病理指标的相关性.方法采用免疫组化方法,检测60例乳腺导管癌及邻近正常组织中VEGF-C和VEGF-R3表达,并将表达结果与淋巴结转移情况及临床病理特征进行统计学分析.结果乳腺导管癌中分别有78%和83%的VEGF-C、VEGF-R3阳性表达,而癌旁及正常乳腺组织散在性弱表达或无表达.VEGF-C在淋巴结转移组表达评分中位数为6,而在非淋巴结转移组评分中住数为1,差异有极显著性(P＜0.01).VEGF-R3在乳腺癌淋巴结转移组与淋巴结非转移组表达评分中位数分别为6.0、2.0,差异亦有极显著性(...

Full description

Saved in:
Bibliographic Details
Published in肿瘤防治研究 Vol. 33; no. 6; pp. 385 - 474
Main Authors 汪蕊, 陈睿, 杨婉华, 马湘一, 王世宣, 卢运萍, 马丁
Format Journal Article
LanguageChinese
Published 430030,武汉,华中科技大学同济医学院附属同济医院妇产科 2006
Subjects
淋巴结转移
乳腺导管癌
VEGF-C
免疫组化
VEGF-R3
Online AccessGet full text
ISSN1000-8578
DOI10.3971/j.issn.1000-8578.2006.06.001

Cover

Abstract R737.9; 目的探讨VEGF-C及其受体VEGF-R3在乳腺导管癌中的表达及与淋巴结转移等临床病理指标的相关性.方法采用免疫组化方法,检测60例乳腺导管癌及邻近正常组织中VEGF-C和VEGF-R3表达,并将表达结果与淋巴结转移情况及临床病理特征进行统计学分析.结果乳腺导管癌中分别有78%和83%的VEGF-C、VEGF-R3阳性表达,而癌旁及正常乳腺组织散在性弱表达或无表达.VEGF-C在淋巴结转移组表达评分中位数为6,而在非淋巴结转移组评分中住数为1,差异有极显著性(P＜0.01).VEGF-R3在乳腺癌淋巴结转移组与淋巴结非转移组表达评分中位数分别为6.0、2.0,差异亦有极显著性(P＜0.01).结论VEGF-C与VEGF-R3在乳腺癌的侵袭进展及区域淋巴结转移方面可能起重要作用.
AbstractList R737.9; 目的探讨VEGF-C及其受体VEGF-R3在乳腺导管癌中的表达及与淋巴结转移等临床病理指标的相关性.方法采用免疫组化方法,检测60例乳腺导管癌及邻近正常组织中VEGF-C和VEGF-R3表达,并将表达结果与淋巴结转移情况及临床病理特征进行统计学分析.结果乳腺导管癌中分别有78%和83%的VEGF-C、VEGF-R3阳性表达,而癌旁及正常乳腺组织散在性弱表达或无表达.VEGF-C在淋巴结转移组表达评分中位数为6,而在非淋巴结转移组评分中住数为1,差异有极显著性(P＜0.01).VEGF-R3在乳腺癌淋巴结转移组与淋巴结非转移组表达评分中位数分别为6.0、2.0,差异亦有极显著性(P＜0.01).结论VEGF-C与VEGF-R3在乳腺癌的侵袭进展及区域淋巴结转移方面可能起重要作用.
Author 杨婉华
王世宣
陈睿
马湘一
卢运萍
马丁
汪蕊
AuthorAffiliation 430030,武汉,华中科技大学同济医学院附属同济医院妇产科
AuthorAffiliation_xml – name: 430030,武汉,华中科技大学同济医学院附属同济医院妇产科
Author_FL YANG Wan-hua
WANG Rui
MA Ding
WANG Shi-xuan
MA Xiang-yi
CHEN Rui
LU Yun-ping
Author_FL_xml – sequence: 1
  fullname: WANG Rui
– sequence: 2
  fullname: CHEN Rui
– sequence: 3
  fullname: YANG Wan-hua
– sequence: 4
  fullname: MA Xiang-yi
– sequence: 5
  fullname: WANG Shi-xuan
– sequence: 6
  fullname: LU Yun-ping
– sequence: 7
  fullname: MA Ding
Author_xml – sequence: 1
  fullname: 汪蕊
– sequence: 2
  fullname: 陈睿
– sequence: 3
  fullname: 杨婉华
– sequence: 4
  fullname: 马湘一
– sequence: 5
  fullname: 王世宣
– sequence: 6
  fullname: 卢运萍
– sequence: 7
  fullname: 马丁
BookMark eNo9T81Kw0AY3EMFa-1bCJ4Sv93N_uQooalCQZDitSRuVhpKCgYRe7YXLQr2pHjxZA96itBqsE-TmDyGqYrMwAzzwTfMBqpFwyhAaAuDSW2Bd0KzH8eRiQHAkExIkwBwc0XANVT_z9dRM477PjApMUgh68g9arVdw8nvJj_mkOaPs-w9Kccfxf0kW7wWD5fl06xcLvPbq2xx8zW_zudvRTotP1-K57S65uOkSNJNtKa9QRw0_7SBum6r6-wZnYP2vrPbMY6ZjQ3JgRCFuWcHfkCo9LkSVBGttaeZpwVTClhACHBOpRIca2ZRi2hhMcvmlNEG2v59e-5F2otOeuHw7DSqCnujgR5dhKvZFQDTb8LWZO4
ClassificationCodes R737.9
ContentType Journal Article
Copyright Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
Copyright_xml – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
DBID 2B.
4A8
92I
93N
PSX
TCJ
DOI 10.3971/j.issn.1000-8578.2006.06.001
DatabaseName Wanfang Data Journals - Hong Kong
WANFANG Data Centre
Wanfang Data Journals
万方数据期刊 - 香港版
China Online Journals (COJ)
China Online Journals (COJ)
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
DocumentTitle_FL Expression of VEGF-C and VEGF-R3 in Breast Cancer and the Relation with Lymphatic Metastasis
EndPage 474
ExternalDocumentID zlfzyj200606001
GrantInformation_xml – fundername: 国家研究发展基金
  funderid: (2002CB513100)
GroupedDBID -05
2B.
4A8
5XA
5XF
92F
92I
93N
ABJNI
ACGFS
ALMA_UNASSIGNED_HOLDINGS
CCEZO
CIEJG
CW9
GROUPED_DOAJ
PSX
TCJ
TGQ
U1G
U5O
ID FETCH-LOGICAL-c591-86022d16a9ebe238b6d73d2fffaf5af75dd05e2206638d761f54342f745496353
ISSN 1000-8578
IngestDate Thu May 29 04:11:40 EDT 2025
IsPeerReviewed true
IsScholarly true
Issue 6
Keywords 淋巴结转移
乳腺导管癌
VEGF-C
免疫组化
VEGF-R3
Language Chinese
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c591-86022d16a9ebe238b6d73d2fffaf5af75dd05e2206638d761f54342f745496353
PageCount 90
ParticipantIDs wanfang_journals_zlfzyj200606001
PublicationCentury 2000
PublicationDate 2006
PublicationDateYYYYMMDD 2006-01-01
PublicationDate_xml – year: 2006
  text: 2006
PublicationDecade 2000
PublicationTitle 肿瘤防治研究
PublicationTitle_FL CANCER RESEARCH ON PREVENTION AND TREATMENT
PublicationYear 2006
Publisher 430030,武汉,华中科技大学同济医学院附属同济医院妇产科
Publisher_xml – name: 430030,武汉,华中科技大学同济医学院附属同济医院妇产科
SSID ssib058810878
ssib001104370
ssib051375314
ssib031740888
ssib038074675
ssib048878127
ssib059160193
ssj0000602894
Score 1.6579822
Snippet R737.9;...
SourceID wanfang
SourceType Aggregation Database
StartPage 385
Title VEGF-C和VEGF-R3在乳腺癌中的表达及与淋巴结转移的关系
URI https://d.wanfangdata.com.cn/periodical/zlfzyj200606001
Volume 33
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR3LbtQwMGqLhLggECDe6qE-piSOndhHezdLhVQOqKDeqmSTgBBaJGgP7IETvUAFEpxAXDjRA5yK1MKKfgJf0WX3M5iZpNm0QuUhrVbOeDwPj-0ZO7HtOHMq0yLtJrmbqES4Qiaem3CdutC6ulmSBGFB5xYs3gwXbosby3J5avpH46ultdV0vtv_7b6S_7EqwMCuuEv2HyxbEwUApMG-8A8Whv-_svGd-HrHbbFYMs2ZatHjrYCeW8woFgtmNbMAUUxJZg2LI6Y1oFKWYqZNEMOUQBzjUynFbIw_oKM6TJkKWQEkZDZiymIWJKzA4tYyTSxsm5kWQgwBJ5QlcQ8IOYCsZkRMsnFmO4QPMgC-xoTlxI5XpIzHNLEzoFG9nEgoILVBMhr4mEmOJlUV0W0Dg2YZAKCmEqkpTRK2QcFmYchBbUKsQq3268A7uExSN2kR4EAGDRZLQLWasBINqPNWzeBAvUM1aR_RoIqVR9IIBGKipACG9MhaQEpScYmP1jZwSE3D9_Wl6ga-Oj6yeF1KIhEVkWCGuFeCNdwVngugZHkJ0r4_Kw8Wqfpt0zkF5eVIVZwjytuRDrtQiE9LF4oM5msG1Ws7enM3CR3qDzr7D4r-k_uI42EEPe0c41Hk4ye2i0_jSXju40latX-A0FWAk6vHf7z7QDTOFgLfEkH8WYfH0g9gcj156y-V8j01OY5OwlQHZixBvcYKsnBFd6HWehx35iolrx2lIm3h6xVJ724j2lw65Zyspomzpuzzp52p_r0zTqfs78PXG1VPH77f3Pu6NV7_Nnq7sbfzefTu2fjD5nh3d_jq-d7Oy5_bL4bbX0aDN-Pvn0YfB5A7XN8abQ3OOkudeKm14Fb3oLhdUMnFW-J45oeJhgEXIuw0zKIg40VRJIVMikhmmSdzjvcyBCqLQr_A7eK8iIQU4F5lcM6Z6T3s5eedWa3SrMiTHCo-E3lYpH4e5T7PCx5JmWpxwZmt1F6phrnHK4dMe_HPKJecE5OFysvOzOqjtfwKhO6r6VVqD78AoA-ulw
linkProvider ISSN International Centre
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=VEGF-C%E5%92%8CVEGF-R3%E5%9C%A8%E4%B9%B3%E8%85%BA%E7%99%8C%E4%B8%AD%E7%9A%84%E8%A1%A8%E8%BE%BE%E5%8F%8A%E4%B8%8E%E6%B7%8B%E5%B7%B4%E7%BB%93%E8%BD%AC%E7%A7%BB%E7%9A%84%E5%85%B3%E7%B3%BB&rft.jtitle=%E8%82%BF%E7%98%A4%E9%98%B2%E6%B2%BB%E7%A0%94%E7%A9%B6&rft.au=%E6%B1%AA%E8%95%8A&rft.au=%E9%99%88%E7%9D%BF&rft.au=%E6%9D%A8%E5%A9%89%E5%8D%8E&rft.au=%E9%A9%AC%E6%B9%98%E4%B8%80&rft.date=2006&rft.pub=430030%2C%E6%AD%A6%E6%B1%89%2C%E5%8D%8E%E4%B8%AD%E7%A7%91%E6%8A%80%E5%A4%A7%E5%AD%A6%E5%90%8C%E6%B5%8E%E5%8C%BB%E5%AD%A6%E9%99%A2%E9%99%84%E5%B1%9E%E5%90%8C%E6%B5%8E%E5%8C%BB%E9%99%A2%E5%A6%87%E4%BA%A7%E7%A7%91&rft.issn=1000-8578&rft.volume=33&rft.issue=6&rft.spage=385&rft.epage=474&rft_id=info:doi/10.3971%2Fj.issn.1000-8578.2006.06.001&rft.externalDocID=zlfzyj200606001
thumbnail_s http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fzlfzyj%2Fzlfzyj.jpg