Ctip1 Controls Acquisition of Sensory Area Identity and Establishment of Sensory Input Fields in the Developing Neocortex

• Published in: Neuron (Cambridge, Mass.) Vol. 90; no. 2; pp. 261 - 277
• Main Authors: Greig, Luciano C., Woodworth, Mollie B., Greppi, Chloé, Macklis, Jeffrey D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.04.2016; Elsevier Limited
• Subjects: Acquisitions & mergers; Animals; Axons - physiology; Carrier Proteins - genetics; Carrier Proteins - metabolism; Carrier Proteins - physiology; Cell Differentiation - genetics; Gene expression; Gene Expression Regulation, Developmental - genetics; Hybridization; Mice; Mice, Knockout; Mutation; Neocortex - cytology; Neocortex - growth & development; Neocortex - physiology; Nervous system; Neurons; Neurons - physiology; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Nuclear Proteins - physiology; Signal Transduction - physiology; Spinal cord; Studies; Thalamus - cytology; Thalamus - physiology; Transcription factors

While transcriptional controls over the size and relative position of cortical areas have been identified, less is known about regulators that direct acquisition of area-specific characteristics. Here, we report that the transcription factor Ctip1 functions in primary sensory areas to repress motor...