Identification and Analysis of Alternative Splicing Events Conserved in Human and Mouse

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 102; no. 8; pp. 2850 - 2855
• Main Authors: Yeo, Gene W., Van Nostrand, Eric, Holste, Dirk, Poggio, Tomaso, Burge, Christopher B., Sharp, Phillip A.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 22.02.2005; National Acad Sciences
• Subjects: Algorithms; Alternative Splicing; Animals; Base Sequence; Biological Evolution; Biological Sciences; Complementary DNA; Conserved Sequence; Evolution; Exons; Expressed Sequence Tags; Genes; Genetics; Humans; Introns; Mice; Oligonucleotides; Reverse transcriptase polymerase chain reaction; Ribonucleic acid; RNA; Splicing

Alternative pre-mRNA splicing affects a majority of human genes and plays important roles in development and disease. Alternative splicing (AS) events conserved since the divergence of human and mouse are likely of primary biological importance, but relatively few of such events are known. Here we d...