The MicroRNA miR-181 Is a Critical Cellular Metabolic Rheostat Essential for NKT Cell Ontogenesis and Lymphocyte Development and Homeostasis

• Published in: Immunity (Cambridge, Mass.) Vol. 38; no. 5; pp. 984 - 997
• Main Authors: Henao-Mejia, Jorge, Williams, Adam, Goff, Loyal A., Staron, Matthew, Licona-Limón, Paula, Kaech, Susan M., Nakayama, Maki, Rinn, John L., Flavell, Richard A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 23.05.2013; Elsevier Limited
• Subjects: Animals; Cell Differentiation; Chemokine CXCL12 - metabolism; Down-Regulation; Homeostasis; Kinases; Lymphocytes - metabolism; Lymphopoiesis - genetics; Metabolism; Mice; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; Natural Killer T-Cells - metabolism; Phosphatase; Phosphatidylinositol 3-Kinases - metabolism; PTEN Phosphohydrolase - metabolism; Rodents; Signal Transduction - genetics; Statistical analysis; T cell receptors

Regulation of metabolic pathways in the immune system provides a mechanism to actively control cellular function, growth, proliferation, and survival. Here, we report that miR-181 is a nonredundant determinant of cellular metabolism and is essential for supporting the biosynthetic demands of early N...