Profiles of SUMO and ubiquitin conjugation in an Alzheimer's disease model

• Published in: Neuroscience letters Vol. 502; no. 3; pp. 201 - 208
• Main Authors: McMillan, Laura E., Brown, Jon T., Henley, Jeremy M., Cimarosti, Helena
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 20.09.2011; Elsevier; Elsevier Scientific Publishers Ireland
• Subjects: Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer's disease; Animals; Biological and medical sciences; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Disease Models, Animal; Fundamental and applied biological sciences. Psychology; GluA1; GluK2/3; Glutamate receptors; Male; Medical sciences; Mice; Mice, Transgenic; Neurology; Posttranslational modification; SENP-1; Small Ubiquitin-Related Modifier Proteins - genetics; Small Ubiquitin-Related Modifier Proteins - metabolism; SUMO; SUMO-1 Protein - genetics; SUMO-1 Protein - metabolism; Sumoylation - genetics; Tg2576 mice; UBC9; Ubiquitin; Ubiquitin-Conjugating Enzymes - genetics; Ubiquitin-Conjugating Enzymes - metabolism; Ubiquitination - genetics; Ubiquitins - genetics; Ubiquitins - metabolism; Vertebrates: nervous system and sense organs; Glutamate receptors; Posttranslational modification; Ubiquitin; GluK2/3; SUMO; UBC9; GluA1; SENP-1; Tg2576 mice; Alzheimer's disease; Nervous system diseases; Alzheimer disease; Rodentia; Glutamate receptor; Cerebral disorder; Vertebrata; Mammalia; Mouse; Animal; Central nervous system disease; Degenerative disease; Models

► Global levels of ubiquitinated proteins increased in the hippocampus of Tg2576 mice. ► No global changes in either SUMO-1 or SUMO-2/3 conjugation in any brain regions analysed. ► SUMO conjugating and deconjugating enzymes, UBC9 and SENP-1, unaltered in Tg2576 mice. ► Total levels of AMPA and kaina...