Increased remineralization of tooth enamel by milk containing added casein phosphopeptide-amorphous calcium phosphate

• Published in: Journal of dairy research Vol. 73; no. 1; pp. 74 - 78
• Main Authors: Walker, Glenn, Cai, Fan, Shen, Peiyan, Reynolds, Coralie, Ward, Brent, Fone, Christopher, Honda, Shuji, Koganei, Megumi, Oda, Munehiro, Reynolds, Eric
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.02.2006
• Subjects: administration & dosage; Administration, Buccal; adults; amorphous calcium phosphate; Animal productions; Animals; Biological and medical sciences; Calcium phosphates; Cariostatic Agents; Cariostatic Agents - administration & dosage; Cariostatic Agents - pharmacology; casein; Casein phosphopeptide; casein phosphopeptides; Caseins; Caseins - administration & dosage; Caseins - pharmacology; Cross-Over Studies; Densitometry; Densitometry - methods; Dental Enamel; Dental Enamel - drug effects; dosage; dose response; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; drug effects; Food industries; food intake; Fundamental and applied biological sciences. Psychology; Humans; Lesions; methods; Microradiography; Microradiography - methods; Milk; Milk and cheese industries. Ice creams; mineralization; pharmacology; phosphoproteins; remineralization; Slabs; Teeth; Terrestrial animal productions; tooth enamel; Tooth Remineralization; Tooth Remineralization - methods; Vertebrates; remineralization; amorphous calcium phosphate; milk; Casein phosphopeptide; tooth enamel; Milk protein; Casein; Dairy industry; Phosphopeptide; Dairy product; Calcium phosphate; Tooth; Milk

Casein phosphopeptide amorphous calcium phosphate nanocomplexes (CPP-ACP) in chewing gum, lozenges and mouthrinses have been shown to remineralize enamel subsurface lesions in human in situ experiments. The aim of this double-blind, randomized clinical study was to investigate the capacity of CPP-AC...