Zinc and the modulation of redox homeostasis

• Published in: Free radical biology & medicine Vol. 53; no. 9; pp. 1748 - 1759
• Main Author: Oteiza, Patricia I.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2012
• Subjects: animal models; Animals; Antioxidant; Antioxidants - metabolism; Antioxidants - physiology; Coordination Complexes - metabolism; cysteine; Free radicals; functional properties; glutathione; Homeostasis; Humans; metabolism; Metalloproteins - metabolism; Metallothionein; Nitric oxide; nutrient deficiencies; oxidants; Oxidation-Reduction; Oxidative Stress; peroxides; Reactive Oxygen Species - metabolism; Redox homeostasis; Redox signaling; Signal Transduction; sulfur; Thiols; Zinc; Zinc - metabolism; Zinc - physiology; Oxidative stress; Thiols; JNK; PTP; RXR; Nrf2; NMDA; GSH; Free radicals; BDNF; VDR; MT; PKC; Akt; MAPK; Antioxidant; Redox signaling; Zinc; GCL; MOR; Redox homeostasis; Nitric oxide; Keap1; GPCR; NMDAR; Metallothionein; ERK

Zinc, a redox-inactive metal, has been long viewed as a component of the antioxidant network, and growing evidence points to its involvement in redox-regulated signaling. These actions are exerted through several mechanisms based on the unique chemical and functional properties of zinc. Overall, zin...