Nonsense-mediated RNA decay and its bipolar function in cancer
Nonsense-mediated decay (NMD) was first described as a quality-control mechanism that targets and rapidly degrades aberrant mRNAs carrying premature termination codons (PTCs). However, it was found that NMD also degrades a significant number of normal transcripts, thus arising as a mechanism of gene...
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Published in | Molecular cancer Vol. 20; no. 1; p. 72 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
BioMed Central
29.04.2021
BMC |
Subjects | |
Online Access | Get full text |
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