Nonsense-mediated RNA decay and its bipolar function in cancer

• Published in: Molecular cancer Vol. 20; no. 1; p. 72
• Main Authors: Nogueira, Gonçalo, Fernandes, Rafael, García-Moreno, Juan F, Romão, Luísa
• Format: Journal Article
• Language: English
• Published: England BioMed Central 29.04.2021; BMC
• Subjects: Biomarker; Cancer; Cancer therapy; Cell cycle; Codons; Gene expression; Gene regulation; Immunotherapy; Kinases; Mutation; Neoantigen; Nonsense-mediated RNA decay (NMD); Peptides; Phosphorylation; Proteins; Quality control; Review; Tumor cells; Tumor suppressor gene; Tumorigenesis; Biomarker; Tumor microenvironment; Cancer therapy; Immunotherapy; Oncogene; Nonsense-mediated RNA decay (NMD); Neoantigen; Environmental stress; Tumor suppressor gene

Nonsense-mediated decay (NMD) was first described as a quality-control mechanism that targets and rapidly degrades aberrant mRNAs carrying premature termination codons (PTCs). However, it was found that NMD also degrades a significant number of normal transcripts, thus arising as a mechanism of gene...