Nonsense-mediated RNA decay and its bipolar function in cancer

Nonsense-mediated decay (NMD) was first described as a quality-control mechanism that targets and rapidly degrades aberrant mRNAs carrying premature termination codons (PTCs). However, it was found that NMD also degrades a significant number of normal transcripts, thus arising as a mechanism of gene...

Full description

Saved in:
Bibliographic Details
Published inMolecular cancer Vol. 20; no. 1; p. 72
Main Authors Nogueira, Gonçalo, Fernandes, Rafael, García-Moreno, Juan F, Romão, Luísa
Format Journal Article
LanguageEnglish
Published England BioMed Central 29.04.2021
BMC
Subjects
Biomarker
Cancer
Cancer therapy
Cell cycle
Codons
Gene expression
Gene regulation
Immunotherapy
Kinases
Mutation
Neoantigen
Nonsense-mediated RNA decay (NMD)
Peptides
Phosphorylation
Proteins
Quality control
Review
Tumor cells
Tumor suppressor gene
Tumorigenesis
Biomarker
Tumor microenvironment
Cancer therapy
Immunotherapy
Oncogene
Nonsense-mediated RNA decay (NMD)
Neoantigen
Environmental stress
Tumor suppressor gene
Online AccessGet full text

Cover

Abstract Nonsense-mediated decay (NMD) was first described as a quality-control mechanism that targets and rapidly degrades aberrant mRNAs carrying premature termination codons (PTCs). However, it was found that NMD also degrades a significant number of normal transcripts, thus arising as a mechanism of gene expression regulation. Based on these important functions, NMD regulates several biological processes and is involved in the pathophysiology of a plethora of human genetic diseases, including cancer. The present review aims to discuss the paradoxical, pro- and anti-tumorigenic roles of NMD, and how cancer cells have exploited both functions to potentiate the disease. Considering recent genetic and bioinformatic studies, we also provide a comprehensive overview of the present knowledge of the advantages and disadvantages of different NMD modulation-based approaches in cancer therapy, reflecting on the challenges imposed by the complexity of this disease. Furthermore, we discuss significant advances in the recent years providing new perspectives on the implications of aberrant NMD-escaping frameshifted transcripts in personalized immunotherapy design and predictive biomarker optimization. A better understanding of how NMD differentially impacts tumor cells according to their own genetic identity will certainly allow for the application of novel and more effective personalized treatments in the near future.
AbstractList Abstract Nonsense-mediated decay (NMD) was first described as a quality-control mechanism that targets and rapidly degrades aberrant mRNAs carrying premature termination codons (PTCs). However, it was found that NMD also degrades a significant number of normal transcripts, thus arising as a mechanism of gene expression regulation. Based on these important functions, NMD regulates several biological processes and is involved in the pathophysiology of a plethora of human genetic diseases, including cancer. The present review aims to discuss the paradoxical, pro- and anti-tumorigenic roles of NMD, and how cancer cells have exploited both functions to potentiate the disease. Considering recent genetic and bioinformatic studies, we also provide a comprehensive overview of the present knowledge of the advantages and disadvantages of different NMD modulation-based approaches in cancer therapy, reflecting on the challenges imposed by the complexity of this disease. Furthermore, we discuss significant advances in the recent years providing new perspectives on the implications of aberrant NMD-escaping frameshifted transcripts in personalized immunotherapy design and predictive biomarker optimization. A better understanding of how NMD differentially impacts tumor cells according to their own genetic identity will certainly allow for the application of novel and more effective personalized treatments in the near future.
Nonsense-mediated decay (NMD) was first described as a quality-control mechanism that targets and rapidly degrades aberrant mRNAs carrying premature termination codons (PTCs). However, it was found that NMD also degrades a significant number of normal transcripts, thus arising as a mechanism of gene expression regulation. Based on these important functions, NMD regulates several biological processes and is involved in the pathophysiology of a plethora of human genetic diseases, including cancer. The present review aims to discuss the paradoxical, pro- and anti-tumorigenic roles of NMD, and how cancer cells have exploited both functions to potentiate the disease. Considering recent genetic and bioinformatic studies, we also provide a comprehensive overview of the present knowledge of the advantages and disadvantages of different NMD modulation-based approaches in cancer therapy, reflecting on the challenges imposed by the complexity of this disease. Furthermore, we discuss significant advances in the recent years providing new perspectives on the implications of aberrant NMD-escaping frameshifted transcripts in personalized immunotherapy design and predictive biomarker optimization. A better understanding of how NMD differentially impacts tumor cells according to their own genetic identity will certainly allow for the application of novel and more effective personalized treatments in the near future.
ArticleNumber 72
Author Nogueira, Gonçalo
Romão, Luísa
García-Moreno, Juan F
Fernandes, Rafael
Author_xml – sequence: 1
  givenname: Gonçalo
  surname: Nogueira
  fullname: Nogueira, Gonçalo
  organization: BioISI - Instituto de Biossistemas e Ciências Integrativas, Faculdade de Ciências, Universidade de Lisboa, 1749-016, Lisbon, Portugal
– sequence: 2
  givenname: Rafael
  surname: Fernandes
  fullname: Fernandes, Rafael
  organization: BioISI - Instituto de Biossistemas e Ciências Integrativas, Faculdade de Ciências, Universidade de Lisboa, 1749-016, Lisbon, Portugal
– sequence: 3
  givenname: Juan F
  surname: García-Moreno
  fullname: García-Moreno, Juan F
  organization: BioISI - Instituto de Biossistemas e Ciências Integrativas, Faculdade de Ciências, Universidade de Lisboa, 1749-016, Lisbon, Portugal
– sequence: 4
  givenname: Luísa
  orcidid: 0000-0002-5061-5287
  surname: Romão
  fullname: Romão, Luísa
  email: luisa.romao@insa.min-saude.pt, luisa.romao@insa.min-saude.pt
  organization: BioISI - Instituto de Biossistemas e Ciências Integrativas, Faculdade de Ciências, Universidade de Lisboa, 1749-016, Lisbon, Portugal. luisa.romao@insa.min-saude.pt
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33926465$$D View this record in MEDLINE/PubMed
BookMark eNpdkVtLHTEUhUNRvNU_0Icy0Je-jOY-yYsg0osgFkr7HHLZY3OYk5wmM4L_vjkeKyoEElbW_pK91zHaSzkBQh8IPiNEyfNKqOasx5T0mDDJe_wOHRE-yJ4LrfZenA_Rca0rjMmgBn6ADhnTVHIpjtDFbU4V2urXEKKdIXQ_by-7AN4-dDaFLs61c3GTJ1u6cUl-jjl1MXXeJg_lPdof7VTh9Gk_Qb-_fvl19b2_-fHt-urypvdC47n33GsIJAwjHeVItPWM260AdBCBeemY1kITGcA2DRy4IWAmCXfOB-7YCbrecUO2K7MpcW3Lg8k2mkchlztjyxz9BEarNhwXWFBEcWHB-tERCp4Lh4UdZWNd7FibxbWmPaS52OkV9PVNin_MXb43Cis6DKIBPj8BSv67QJ3NOlYP02QT5KUaKihWEguyfevTG-sqLyW1UW1dSgssNWsuunP5kmstMD5_hmCzjdrsojYtavMYtcGt6OPLNp5L_mfL_gEwm6bt
CitedBy_id crossref_primary_10_5483_BMBRep_2023_0190
crossref_primary_10_3892_mmr_2022_12726
crossref_primary_10_3390_cancers16051072
crossref_primary_10_1016_j_bbrc_2022_06_055
crossref_primary_10_1038_s41598_023_36568_5
crossref_primary_10_1016_j_pathol_2023_11_013
crossref_primary_10_2147_JHC_S450711
crossref_primary_10_3390_biomedicines9080995
crossref_primary_10_1038_s41598_024_61062_x
crossref_primary_10_3390_genes14020357
crossref_primary_10_1016_j_jhepr_2024_101118
crossref_primary_10_3390_biomedicines10030665
crossref_primary_10_3390_biomedicines11030659
crossref_primary_10_1093_nar_gkab882
crossref_primary_10_1016_j_abb_2024_109989
crossref_primary_10_3390_toxics11100856
crossref_primary_10_1016_j_tibs_2022_06_003
crossref_primary_10_3389_fphar_2021_701454
crossref_primary_10_1142_S0219720023500208
crossref_primary_10_1016_j_heliyon_2024_e25716
crossref_primary_10_3389_fcell_2022_1064754
crossref_primary_10_1016_j_ekir_2021_12_012
crossref_primary_10_1007_s12033_023_00927_4
crossref_primary_10_3390_biomedicines11102801
crossref_primary_10_1016_j_molcel_2023_12_010
crossref_primary_10_15252_embj_2023114378
crossref_primary_10_3389_fonc_2022_871169
crossref_primary_10_1093_bioinformatics_btad556
crossref_primary_10_3390_ijms241210258
crossref_primary_10_1038_s41568_022_00481_2
crossref_primary_10_3390_biomedicines10010141
crossref_primary_10_1016_j_ymthe_2023_01_014
crossref_primary_10_3390_cells11233859
crossref_primary_10_1016_j_micinf_2023_105220
crossref_primary_10_3390_cancers14133255
crossref_primary_10_1007_s12033_024_01062_4
crossref_primary_10_3390_ijms23169329
crossref_primary_10_1080_07391102_2023_2262587
Cites_doi 10.1002/hep.29683
10.1186/s13046-016-0286-2
10.1093/nar/gki905
10.15252/embj.201797079
10.1101/gad.1717309
10.1002/humu.20763
10.1093/emboj/20.4.880
10.1158/1541-7786.MCR-09-0502
10.1023/A:1004091122351
10.1016/S0968-0004(98)01208-0
10.1038/s41467-020-17526-5
10.15252/embr.201439696
10.1038/nm.3548
10.1038/s41388-018-0132-4
10.1016/j.molcel.2008.11.022
10.1038/ncomms5177
10.1016/j.micinf.2013.03.006
10.1093/nar/gku1258
10.1016/j.celrep.2014.01.028
10.1128/MCB.05704-11
10.1002/jcp.25622
10.1261/rna.038893.113
10.1002/bies.201300156
10.1038/sj.emboj.7601628
10.1261/rna.1386208
10.1093/emboj/20.17.4987
10.1093/hmg/10.2.99
10.1016/j.cell.2009.02.042
10.1007/s00262-011-1172-6
10.1002/1097-0142(20011015)92:8<2164::AID-CNCR1559>3.0.CO;2-A
10.15252/embr.201642195
10.1038/gt.2014.101
10.1038/mp.2009.14
10.1101/gad.332270.119
10.1002/ajmg.a.20632
10.1073/pnas.1007336107
10.1038/nm.4416
10.1093/nar/gkv668
10.1093/nar/gkr791
10.1038/nsmb.1750
10.1261/rna.815108
10.1016/S1097-2765(03)00502-1
10.1007/BF00299157
10.1016/j.febslet.2008.12.058
10.1016/j.intimp.2018.06.001
10.1038/nm0496-467
10.1128/MCB.26.4.1272-1287.2006
10.1038/sj.onc.1206075
10.1017/S1355838202028030
10.1038/sj.onc.1209033
10.1038/nrm3270
10.1016/j.humpath.2007.10.021
10.1038/srep44674
10.1042/BST0360497
10.1093/nar/gkz193
10.1016/j.semcdb.2017.08.053
10.1017/S1355838200000960
10.1172/JCI86508
10.18632/oncotarget.6940
10.1016/j.molcel.2019.05.008
10.2147/CMAR.S244486
10.1038/onc.2008.62
10.1101/gad.819900
10.1159/000479994
10.1038/ng0692-209
10.1182/blood-2006-11-057208
10.1073/pnas.1219725110
10.1007/978-0-387-77374-2_12
10.1038/mp.2011.163
10.1002/humu.20590
10.1093/hmg/dds223
10.1038/s41580-019-0126-2
10.1038/nature08999
10.1038/s41598-018-37186-2
10.1007/s00018-017-2537-6
10.1038/nature13954
10.1186/1471-2164-11-565
10.1016/j.molcel.2004.10.013
10.1146/annurev.biochem.76.050106.093909
10.1371/journal.pgen.1005863
10.1038/s41588-019-0517-5
10.1016/j.tranon.2019.12.010
10.1002/emmm.201303347
10.1093/hmg/ddi131
10.1074/jbc.M107666200
10.1038/cdd.2015.18
10.15252/embj.201489947
10.1084/jem.184.5.1781
10.1101/gad.1767209
10.1038/cr.2014.151
10.1158/0008-5472.CAN-18-2868
10.1002/ijc.1491
10.1016/j.molcel.2005.08.012
10.1007/s00109-007-0281-3
10.1093/hmg/11.23.2805
10.1016/j.molcel.2016.03.021
10.1186/s13059-020-02240-8
10.1038/s41389-018-0079-x
10.1038/ng.3664
10.1016/j.cell.2016.02.046
10.1101/gad.1389006
10.1038/nature12730
10.1371/journal.pbio.0060092
10.1038/nsmb.1530
10.1016/j.celrep.2018.04.039
10.1016/j.bbrc.2019.04.054
10.1038/nature02559
10.1261/rna.059055.116
10.1093/nar/gkp908
10.1038/ng1429
10.1083/jcb.200611086
10.1089/10507250152740939
10.1016/j.molcel.2005.01.010
10.1038/7701
10.1038/ng.621
10.1093/emboj/17.12.3484
10.1038/emboj.2010.81
10.1093/emboj/19.24.6860
10.1016/j.chom.2014.08.007
10.1073/pnas.95.13.7556
10.1017/S1355838200991660
10.1371/journal.pone.0055684
10.4161/rna.22360
10.1016/j.immuni.2016.06.001
10.1074/jbc.270.18.10878
10.3390/ijms21249424
10.18632/oncotarget.16603
10.1093/nar/gkx778
10.1073/pnas.1000993107
10.1038/nbt.3427
10.1016/j.gene.2012.07.083
10.1186/s12885-017-3747-x
10.1016/j.mrrev.2014.05.001
10.1038/nsmb1330
10.1146/annurev-genet-111212-133424
10.1016/j.str.2014.05.015
10.1016/j.molcel.2011.06.031
10.1093/emboj/20.7.1785
10.1186/1750-1172-7-58
10.1261/rna.030247.111
10.1016/j.celrep.2014.08.020
10.1038/nsmb1081
10.1056/NEJM199612263352604
10.1155/2015/417281
10.1074/jbc.M111.266361
10.1128/MCB.00361-08
10.1038/sj.emboj.7601712
10.1038/s41467-019-10606-1
10.1073/pnas.88.15.6481
10.1038/s41577-020-0306-5
10.1016/j.celrep.2014.09.012
10.1093/emboj/cdf345
10.1158/1535-7163.MCT-17-0386
10.1016/j.molcel.2005.10.026
10.1093/hmg/ddt035
10.1128/MCB.19.10.6710
10.1007/s00109-011-0787-6
10.1038/nrm1310
10.1016/S0092-8674(01)00475-5
10.1128/MCB.02284-07
10.1128/JVI.07021-11
10.1155/2013/358015
10.18632/oncotarget.13677
10.1038/nature05676
10.1038/ncomms7632
10.1101/gad.606911
10.1038/ncomms10585
10.1261/rna.201406
10.15252/embj.201798063
10.1182/blood.V97.7.2059
10.1158/0008-5472.CAN-13-2235
10.1101/gad.468808
10.1165/rcmb.2013-0282OC
10.1242/dev.000018
10.1016/j.gde.2017.10.007
10.1016/j.tcb.2008.04.005
10.1038/ng2100
10.1016/S0168-9525(00)02176-4
10.1371/journal.pone.0011650
10.1016/0092-8674(81)90396-2
10.7554/eLife.12876
10.1016/S1097-2765(03)00446-5
10.1016/j.biocel.2017.07.013
10.1038/ng.620
10.1038/nsmb.1612
10.1016/j.cell.2015.10.012
10.1016/1074-7613(94)90087-6
10.1073/pnas.0136770100
10.1074/jbc.270.15.8936
10.1038/nrm4063
10.1073/pnas.76.10.5134
10.1016/j.ccell.2015.04.006
10.1038/nature08909
10.1038/nature11112
10.3389/fonc.2019.00989
10.1016/j.canlet.2017.06.021
10.1016/S1097-2765(03)00349-6
10.1128/MCB.00174-13
10.1074/jbc.270.48.28995
10.1038/nm.3620
10.1002/cncr.11619
10.1038/sj.onc.1205033
10.1038/emboj.2008.17
10.1101/gad.246538.114
10.1261/rna.058040.116
10.1002/jcb.21194
10.1016/j.molcel.2011.04.018
10.1038/sj.emboj.7601977
10.1371/journal.pbio.0060111
10.1016/j.ajhg.2016.02.010
10.1038/onc.2014.352
10.1158/0008-5472.CAN-08-1997
10.1016/j.ccr.2006.06.001
10.1038/ncomms8581
10.1242/jcs.198176
ContentType Journal Article
Copyright 2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
The Author(s) 2021
Copyright_xml – notice: 2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: The Author(s) 2021
DBID NPM
AAYXX
CITATION
3V.
7TO
7X7
7XB
88E
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
H94
K9.
M0S
M1P
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
DOA
DOI 10.1186/s12943-021-01364-0
DatabaseName PubMed
CrossRef
ProQuest Central (Corporate)
Oncogenes and Growth Factors Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
Directory of Open Access Journals
DatabaseTitle PubMed
CrossRef
Publicly Available Content Database
Oncogenes and Growth Factors Abstracts
ProQuest Central Essentials
ProQuest One Academic Eastern Edition
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Central China
ProQuest Hospital Collection (Alumni)
ProQuest Central
ProQuest Health & Medical Complete
Health Research Premium Collection
ProQuest Medical Library
ProQuest One Academic UKI Edition
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
AIDS and Cancer Research Abstracts
ProQuest One Academic
ProQuest Medical Library (Alumni)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList CrossRef

Publicly Available Content Database
PubMed
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Biology
EISSN 1476-4598
EndPage 72
ExternalDocumentID oai_doaj_org_article_98118bd3d81845aeacfb12ec45b05af6
10_1186_s12943_021_01364_0
33926465
Genre Research Support, Non-U.S. Gov't
Journal Article
Review
GrantInformation_xml – fundername: ;
  grantid: SFRH/PD/BD/130959/2017; SFRH/BD/114392/2016; SFRH/PD/BD/142898/2018
GroupedDBID ---
-A0
0R~
123
29M
2WC
3V.
53G
5VS
7X7
88E
8FI
8FJ
AAFWJ
AAJSJ
ABDBF
ABUWG
ACGFO
ACGFS
ACIHN
ACIWK
ACMJI
ACPRK
ACRMQ
ADBBV
ADINQ
ADRAZ
ADUKV
AEAQA
AENEX
AFKRA
AFPKN
AFRAH
AHBYD
AHMBA
AHYZX
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMTXH
AOIJS
BAPOH
BAWUL
BCNDV
BENPR
BFQNJ
BMC
BPHCQ
BVXVI
C24
C6C
CCPQU
CS3
DIK
DU5
E3Z
EAD
EAP
EAS
EBD
EBLON
EBS
EMB
EMK
EMOBN
ESX
F5P
FRP
FYUFA
GROUPED_DOAJ
GX1
HH5
HMCUK
HYE
IAO
IHR
INH
INR
ITC
KQ8
M1P
M48
M~E
NPM
O5R
O5S
OK1
P2P
PGMZT
PIMPY
PQQKQ
PROAC
PSQYO
PZZ
RBZ
RNS
ROL
RPM
RSV
SBL
SOJ
SV3
TR2
TUS
UKHRP
W2D
WOQ
WOW
XSB
AAYXX
CITATION
7TO
7XB
8FK
AZQEC
DWQXO
H94
K9.
PQEST
PQUKI
PRINS
7X8
AFGXO
5PM
ID FETCH-LOGICAL-c590t-c4c9ed1d7f2f6f19ac34aed1de275d3c6b3995916deade2ebeb7d03614bbcd4b3
IEDL.DBID RPM
ISSN 1476-4598
IngestDate Tue Oct 22 15:12:55 EDT 2024
Tue Sep 17 21:17:36 EDT 2024
Fri Aug 16 20:44:49 EDT 2024
Thu Oct 10 19:21:10 EDT 2024
Wed Sep 04 12:35:00 EDT 2024
Sat Sep 28 08:45:53 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Biomarker
Tumor microenvironment
Cancer therapy
Immunotherapy
Oncogene
Nonsense-mediated RNA decay (NMD)
Neoantigen
Environmental stress
Tumor suppressor gene
Language English
License Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c590t-c4c9ed1d7f2f6f19ac34aed1de275d3c6b3995916deade2ebeb7d03614bbcd4b3
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ORCID 0000-0002-5061-5287
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082775/
PMID 33926465
PQID 2528950693
PQPubID 42702
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_98118bd3d81845aeacfb12ec45b05af6
pubmedcentral_primary_oai_pubmedcentral_nih_gov_8082775
proquest_miscellaneous_2520860516
proquest_journals_2528950693
crossref_primary_10_1186_s12943_021_01364_0
pubmed_primary_33926465
PublicationCentury 2000
PublicationDate 2021-04-29
PublicationDateYYYYMMDD 2021-04-29
PublicationDate_xml – month: 04
  year: 2021
  text: 2021-04-29
  day: 29
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
– name: London
PublicationTitle Molecular cancer
PublicationTitleAlternate Mol Cancer
PublicationYear 2021
Publisher BioMed Central
BMC
Publisher_xml – name: BioMed Central
– name: BMC
References E Nagy (1364_CR83) 1998; 23
SM Medghalchi (1364_CR86) 2001; 10
A Bokhari (1364_CR157) 2018; 7
LE Maquat (1364_CR41) 2004; 5
S Lykke-Andersen (1364_CR67) 2014; 28
LE Maquat (1364_CR6) 1981; 27
R Karam (1364_CR109) 2015; 16
JC Reddy (1364_CR24) 1995; 270
LP Vu (1364_CR180) 2017; 23
L Martin (1364_CR204) 2014; 74
T Kurosaki (1364_CR158) 2019; 20
R Melero (1364_CR46) 2016; 7
F Laumonnier (1364_CR101) 2010; 15
F Lejeune (1364_CR37) 2002; 21
S Wang (1364_CR188) 2001; 11
DH Kaplan (1364_CR206) 1998; 95
L Guo (1364_CR189) 2017; 7
L Barrueto (1364_CR215) 2020; 13
C Hetz (1364_CR111) 2012; 13
IB Rosenwald (1364_CR186) 2008; 39
D Dominissini (1364_CR175) 2012; 485
FH Saleh (1364_CR210) 2001; 94
E Kim (1364_CR160) 2015; 27
AS Dighe (1364_CR208) 1994; 1
AB Eberle (1364_CR63) 2009; 16
IG Bruno (1364_CR100) 2011; 42
KD Meyer (1364_CR178) 2015; 163
KM Hargadon (1364_CR212) 2018; 62
J Jia (1364_CR203) 2017; 130
T Li (1364_CR87) 2015; 34
N Fukuhara (1364_CR68) 2005; 17
A Yamashita (1364_CR44) 2009; 23
G Singh (1364_CR57) 2008; 6
KL Jackson (1364_CR194) 2015; 22
PV Ivanov (1364_CR55) 2008; 27
1364_CR56
R Losson (1364_CR5) 1979; 76
O Mühlemann (1364_CR73) 2017; 36
J Ye (1364_CR150) 2010; 29
IB Rosenwald (1364_CR184) 2003; 98
L Li (1364_CR195) 2017; 42
M Cuccurese (1364_CR135) 2005; 33
M Howard (1364_CR144) 1996; 2
YQ Zhou (1364_CR167) 2003; 22
J Lu (1364_CR28) 2016; 126
LF Lareau (1364_CR117) 2007; 623
CH Sung (1364_CR141) 1991; 88
K Degenhardt (1364_CR149) 2006; 10
SM Rowe (1364_CR143) 2011; 89
MF Van Den Broek (1364_CR207) 1996; 184
1364_CR60
G Balistreri (1364_CR114) 2014; 16
L Huang (1364_CR76) 2011; 43
NH Gehring (1364_CR39) 2009; 137
G Neu-Yilik (1364_CR72) 2017; 36
Y Ling (1364_CR169) 2017; 8
IB Rosenwald (1364_CR187) 2001; 92
H Le Hir (1364_CR38) 2000; 19
R Fernandes (1364_CR151) 2019
MS Carter (1364_CR30) 1995; 270
JMA Turner (1364_CR96) 2007; 134
G Sashida (1364_CR163) 2014; 5
V Boehm (1364_CR65) 2014; 9
AD Waldman (1364_CR213) 2020; 20
DR McIlwain (1364_CR88) 2010; 107
NH Gehring (1364_CR74) 2005; 20
C Liu (1364_CR27) 2014; 20
R Karam (1364_CR155) 2008; 27
AL Silva (1364_CR82) 2009; 583
LA Thoren (1364_CR93) 2010; 5
R Kayali (1364_CR200) 2012; 21
H Le Hir (1364_CR32) 2000; 19
BP Lewis (1364_CR122) 2003; 100
M Oka (1364_CR222) 2021; 22
NJ McGlincy (1364_CR130) 2010; 11
Y Gordiyenko (1364_CR112) 2019; 10
D Wang (1364_CR26) 2011; 31
K Litchfield (1364_CR221) 2020; 11
H Chamieh (1364_CR49) 2008; 15
H Cho (1364_CR62) 2009; 33
H Tani (1364_CR91) 2013; 8
Y-F Chang (1364_CR123) 2007; 76
S Lykke-Andersen (1364_CR3) 2015; 16
L Stalder (1364_CR40) 2008; 18
E Arias-Palomo (1364_CR48) 2011; 25
PJ Rosenfeld (1364_CR140) 1992; 1
S Fan (1364_CR156) 2001; 20
F Li (1364_CR183) 2019; 79
JO Nelson (1364_CR90) 2016; 5
S Sun (1364_CR128) 2010; 17
LB Gardner (1364_CR146) 2010; 8
S Lin (1364_CR181) 2016; 62
S Gonzalez-Hilarion (1364_CR198) 2012; 7
R Shaheen (1364_CR89) 2016; 98
S Durand (1364_CR201) 2007; 178
J Bao (1364_CR94) 2015; 142
I Kashima (1364_CR42) 2006; 20
CC Chen (1364_CR172) 2001; 276
C Gong (1364_CR97) 2009; 23
MW Popp (1364_CR2) 2018; 48
L Chang (1364_CR152) 2016; 35
M Hirschfeld (1364_CR174) 2009; 69
M Bartosovic (1364_CR177) 2017; 45
DS Millar (1364_CR139) 2000; 106
R Schneppenheim (1364_CR138) 2001; 97
F Fiorini (1364_CR61) 2015; 6
CC Oliveira (1364_CR84) 1995; 270
C Giampietri (1364_CR148) 2015; 2015
M Mort (1364_CR19) 2008; 29
M Colombo (1364_CR17) 2017; 23
LF Lareau (1364_CR125) 2007; 446
MA Rahman (1364_CR159) 2020; 34
Y Chen (1364_CR171) 2007; 100
SR Sirkisoon (1364_CR154) 2018; 37
AL Saltzman (1364_CR133) 2008; 28
YK Kim (1364_CR98) 2007; 26
BJ Lam (1364_CR132) 2002; 8
PC Tumeh (1364_CR216) 2014; 515
QM Mitrovich (1364_CR134) 2000; 14
F Lejeune (1364_CR70) 2003; 12
K Pakos-Zebrucka (1364_CR110) 2016; 17
M Chen (1364_CR182) 2018; 67
W Chan (1364_CR34) 2007; 26
D Wang (1364_CR107) 2011; 286
A Deniaud (1364_CR50) 2015; 43
N Hug (1364_CR45) 2014; 8
D Gatfield (1364_CR69) 2004; 429
E Jouanguy (1364_CR136) 1999; 21
AS Plomp (1364_CR142) 2004; 126
O Anczuków (1364_CR20) 2008; 29
AE Goetz (1364_CR8) 2017; 74
Y Okada-Katsuhata (1364_CR52) 2012; 40
R Thermann (1364_CR29) 1998; 17
M Mourtada-Maarabouni (1364_CR92) 2013; 2013
F Supek (1364_CR211) 2020; S0168-9525
S Nasif (1364_CR18) 2018; 75
RR Ji (1364_CR217) 2012; 61
MD Ware (1364_CR25) 2006; 25
X Zhao (1364_CR176) 2014; 24
Y Ishigaki (1364_CR36) 2001; 106
J Weischenfeldt (1364_CR11) 2008; 22
GM Halliday (1364_CR209) 1995; 19
MC Brahimi-Horn (1364_CR170) 2007; 85
R Karam (1364_CR104) 2015; 16
X Wang (1364_CR179) 2014; 505
S Krishnaswamy (1364_CR168) 2017; 17
SA Bin (1364_CR81) 2008; 27
J Wittmann (1364_CR13) 2006; 26
L Cao (1364_CR147) 2017; 403
D Pervouchine (1364_CR129) 2019; 47
H Le Hir (1364_CR33) 2001; 20
SA Schmidt (1364_CR66) 2015; 43
C Ghigna (1364_CR166) 2005; 20
RGH Lindeboom (1364_CR219) 2019; 51
AV Kononenko (1364_CR59) 2010; 38
MVT Lobo (1364_CR185) 2000; 32
YT Huang (1364_CR173) 2017; 8
JT Mendell (1364_CR14) 2004; 36
W-K Chan (1364_CR12) 2007; 26
1364_CR77
H Zeng (1364_CR191) 2016; 7
J Jia (1364_CR196) 2015; 22
G Buchwald (1364_CR43) 2010; 107
Y Ge (1364_CR124) 2014; 36
E Jouanguy (1364_CR137) 1996; 335
TT Nomakuchi (1364_CR205) 2016; 34
EY Shum (1364_CR47) 2016; 165
W Wang (1364_CR58) 2001; 20
J Bao (1364_CR95) 2016; 12
RGH Lindeboom (1364_CR21) 2016; 48
S Metze (1364_CR31) 2013; 19
E Huntzinger (1364_CR64) 2008; 14
PS Tarpey (1364_CR102) 2007; 39
T Ernst (1364_CR161) 2010; 42
O Kelemen (1364_CR121) 2013; 514
H Yepiskoposyan (1364_CR16) 2011; 17
W Yu (1364_CR164) 2019; 9
O Mühlemann (1364_CR80) 2008; 36
JF García-Moreno (1364_CR118) 2020; 21
EC Wolstencroft (1364_CR145) 2005; 14
MW-L Popp (1364_CR4) 2013; 47
W-K Chan (1364_CR78) 2009; 16
LS Nguyen (1364_CR10) 2012; 17
MJ Lelivelt (1364_CR79) 1999; 19
AB Eberle (1364_CR54) 2008; 6
LS Nguyen (1364_CR103) 2013; 22
X Bao (1364_CR153) 2020; 12
M Bühler (1364_CR75) 2006; 13
R Melero (1364_CR51) 2014; 22
L Unterholzner (1364_CR71) 2004; 16
Z Li (1364_CR108) 2017; 23
F Pastor (1364_CR220) 2010; 465
L Perrin-Vidoz (1364_CR22) 2002; 11
G Nikoloski (1364_CR162) 2010; 42
L Martin (1364_CR106) 2015; 34
A Sureau (1364_CR126) 2001; 20
F He (1364_CR15) 2003; 12
M Pinyol (1364_CR23) 2007; 109
BR Graveley (1364_CR131) 2000; 6
X Xue (1364_CR199) 2014; 50
CH Lou (1364_CR99) 2014; 6
LB Gardner (1364_CR105) 2008; 28
A Nickless (1364_CR202) 2014; 20
H Tani (1364_CR9) 2012; 9
JM Pitt (1364_CR214) 2016; 44
A Alexandrov (1364_CR35) 2012; 109
ML Matos (1364_CR165) 2017; 232
Z Shi (1364_CR190) 2019; 9
X Sun (1364_CR53) 2000; 6
MC Wollerton (1364_CR127) 2004; 13
AM Goodman (1364_CR218) 2017; 16
BR Graveley (1364_CR119) 2001; 17
V Tano (1364_CR193) 2019; 513
K Nakano (1364_CR116) 2013; 15
J Wengrod (1364_CR192) 2013; 33
TA Hoek (1364_CR85) 2019; 75
YS Oren (1364_CR113) 2014; 6
JN Miller (1364_CR7) 2014; 762
V Mocquet (1364_CR115) 2012; 86
TW Nilsen (1364_CR120) 2010; 463
PJ da Costa (1364_CR1) 2017; 91
MW Popp (1364_CR197) 2015; 6
References_xml – volume: 67
  start-page: 2254
  year: 2018
  ident: 1364_CR182
  publication-title: Hepatology.
  doi: 10.1002/hep.29683
  contributor:
    fullname: M Chen
– volume: 35
  start-page: 8
  year: 2016
  ident: 1364_CR152
  publication-title: J Exp Clin Cancer Res
  doi: 10.1186/s13046-016-0286-2
  contributor:
    fullname: L Chang
– volume: 33
  start-page: 5965
  year: 2005
  ident: 1364_CR135
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gki905
  contributor:
    fullname: M Cuccurese
– volume: 36
  start-page: 2968
  year: 2017
  ident: 1364_CR72
  publication-title: EMBO J
  doi: 10.15252/embj.201797079
  contributor:
    fullname: G Neu-Yilik
– volume: 23
  start-page: 54
  year: 2009
  ident: 1364_CR97
  publication-title: Genes Dev
  doi: 10.1101/gad.1717309
  contributor:
    fullname: C Gong
– volume: 29
  start-page: 1037
  year: 2008
  ident: 1364_CR19
  publication-title: Hum Mutat
  doi: 10.1002/humu.20763
  contributor:
    fullname: M Mort
– volume: 20
  start-page: 880
  year: 2001
  ident: 1364_CR58
  publication-title: EMBO J
  doi: 10.1093/emboj/20.4.880
  contributor:
    fullname: W Wang
– start-page: 41
  volume-title: Adv Exp med biol
  year: 2019
  ident: 1364_CR151
  contributor:
    fullname: R Fernandes
– volume: 8
  start-page: 295
  year: 2010
  ident: 1364_CR146
  publication-title: Mol Cancer Res
  doi: 10.1158/1541-7786.MCR-09-0502
  contributor:
    fullname: LB Gardner
– volume: 32
  start-page: 139
  year: 2000
  ident: 1364_CR185
  publication-title: Histochem J
  doi: 10.1023/A:1004091122351
  contributor:
    fullname: MVT Lobo
– volume: 23
  start-page: 198
  year: 1998
  ident: 1364_CR83
  publication-title: Trends Biochem Sci
  doi: 10.1016/S0968-0004(98)01208-0
  contributor:
    fullname: E Nagy
– volume: 11
  start-page: 1
  year: 2020
  ident: 1364_CR221
  publication-title: Nat Commun
  doi: 10.1038/s41467-020-17526-5
  contributor:
    fullname: K Litchfield
– volume: 16
  start-page: 599
  year: 2015
  ident: 1364_CR109
  publication-title: EMBO Rep
  doi: 10.15252/embr.201439696
  contributor:
    fullname: R Karam
– volume: 20
  start-page: 596
  year: 2014
  ident: 1364_CR27
  publication-title: Nat Med
  doi: 10.1038/nm.3548
  contributor:
    fullname: C Liu
– volume: 37
  start-page: 2502
  year: 2018
  ident: 1364_CR154
  publication-title: Oncogene.
  doi: 10.1038/s41388-018-0132-4
  contributor:
    fullname: SR Sirkisoon
– volume: 33
  start-page: 75
  year: 2009
  ident: 1364_CR62
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2008.11.022
  contributor:
    fullname: H Cho
– volume: 5
  start-page: 4177
  year: 2014
  ident: 1364_CR163
  publication-title: Nat Commun
  doi: 10.1038/ncomms5177
  contributor:
    fullname: G Sashida
– volume: 15
  start-page: 491
  year: 2013
  ident: 1364_CR116
  publication-title: Microbes Infect
  doi: 10.1016/j.micinf.2013.03.006
  contributor:
    fullname: K Nakano
– volume: 43
  start-page: 309
  year: 2015
  ident: 1364_CR66
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gku1258
  contributor:
    fullname: SA Schmidt
– volume: 6
  start-page: 748
  year: 2014
  ident: 1364_CR99
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2014.01.028
  contributor:
    fullname: CH Lou
– volume: 31
  start-page: 3670
  year: 2011
  ident: 1364_CR26
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.05704-11
  contributor:
    fullname: D Wang
– volume: 232
  start-page: 1368
  year: 2017
  ident: 1364_CR165
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.25622
  contributor:
    fullname: ML Matos
– volume: 19
  start-page: 1432
  year: 2013
  ident: 1364_CR31
  publication-title: RNA.
  doi: 10.1261/rna.038893.113
  contributor:
    fullname: S Metze
– volume: 36
  start-page: 236
  year: 2014
  ident: 1364_CR124
  publication-title: BioEssays.
  doi: 10.1002/bies.201300156
  contributor:
    fullname: Y Ge
– volume: 26
  start-page: 1820
  year: 2007
  ident: 1364_CR12
  publication-title: EMBO J
  doi: 10.1038/sj.emboj.7601628
  contributor:
    fullname: W-K Chan
– volume: 14
  start-page: 2609
  year: 2008
  ident: 1364_CR64
  publication-title: RNA.
  doi: 10.1261/rna.1386208
  contributor:
    fullname: E Huntzinger
– volume: 20
  start-page: 4987
  year: 2001
  ident: 1364_CR33
  publication-title: EMBO J
  doi: 10.1093/emboj/20.17.4987
  contributor:
    fullname: H Le Hir
– volume: 10
  start-page: 99
  year: 2001
  ident: 1364_CR86
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/10.2.99
  contributor:
    fullname: SM Medghalchi
– volume: 137
  start-page: 536
  year: 2009
  ident: 1364_CR39
  publication-title: Cell.
  doi: 10.1016/j.cell.2009.02.042
  contributor:
    fullname: NH Gehring
– volume: 61
  start-page: 1019
  year: 2012
  ident: 1364_CR217
  publication-title: Cancer Immunol Immunother
  doi: 10.1007/s00262-011-1172-6
  contributor:
    fullname: RR Ji
– volume: 92
  start-page: 2164
  year: 2001
  ident: 1364_CR187
  publication-title: Cancer.
  doi: 10.1002/1097-0142(20011015)92:8<2164::AID-CNCR1559>3.0.CO;2-A
  contributor:
    fullname: IB Rosenwald
– volume: 17
  start-page: 1374
  year: 2016
  ident: 1364_CR110
  publication-title: EMBO Rep
  doi: 10.15252/embr.201642195
  contributor:
    fullname: K Pakos-Zebrucka
– volume: 22
  start-page: 20
  year: 2015
  ident: 1364_CR194
  publication-title: Gene Ther
  doi: 10.1038/gt.2014.101
  contributor:
    fullname: KL Jackson
– volume: 15
  start-page: 767
  year: 2010
  ident: 1364_CR101
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2009.14
  contributor:
    fullname: F Laumonnier
– volume: 34
  start-page: 413
  year: 2020
  ident: 1364_CR159
  publication-title: Genes Dev
  doi: 10.1101/gad.332270.119
  contributor:
    fullname: MA Rahman
– volume: 126
  start-page: 403
  issue: A
  year: 2004
  ident: 1364_CR142
  publication-title: Am J Med Genet
  doi: 10.1002/ajmg.a.20632
  contributor:
    fullname: AS Plomp
– volume: 107
  start-page: 12186
  year: 2010
  ident: 1364_CR88
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1007336107
  contributor:
    fullname: DR McIlwain
– volume: 23
  start-page: 1369
  year: 2017
  ident: 1364_CR180
  publication-title: Nat Med
  doi: 10.1038/nm.4416
  contributor:
    fullname: LP Vu
– volume: 43
  start-page: 7600
  year: 2015
  ident: 1364_CR50
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkv668
  contributor:
    fullname: A Deniaud
– volume: 40
  start-page: 1251
  year: 2012
  ident: 1364_CR52
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkr791
  contributor:
    fullname: Y Okada-Katsuhata
– volume: 17
  start-page: 306
  year: 2010
  ident: 1364_CR128
  publication-title: Nat Struct Mol Biol
  doi: 10.1038/nsmb.1750
  contributor:
    fullname: S Sun
– volume: 16
  start-page: 599
  year: 2015
  ident: 1364_CR104
  publication-title: EMBO Rep
  doi: 10.15252/embr.201439696
  contributor:
    fullname: R Karam
– ident: 1364_CR56
  doi: 10.1261/rna.815108
– volume: 13
  start-page: 91
  year: 2004
  ident: 1364_CR127
  publication-title: Mol Cell
  doi: 10.1016/S1097-2765(03)00502-1
  contributor:
    fullname: MC Wollerton
– volume: 19
  start-page: 352
  year: 1995
  ident: 1364_CR209
  publication-title: World J Surg
  doi: 10.1007/BF00299157
  contributor:
    fullname: GM Halliday
– volume: 583
  start-page: 499
  year: 2009
  ident: 1364_CR82
  publication-title: FEBS Lett
  doi: 10.1016/j.febslet.2008.12.058
  contributor:
    fullname: AL Silva
– volume: 62
  start-page: 29
  year: 2018
  ident: 1364_CR212
  publication-title: Int Immunopharmacol
  doi: 10.1016/j.intimp.2018.06.001
  contributor:
    fullname: KM Hargadon
– volume: 2
  start-page: 467
  year: 1996
  ident: 1364_CR144
  publication-title: Nat Med
  doi: 10.1038/nm0496-467
  contributor:
    fullname: M Howard
– volume: 26
  start-page: 1272
  year: 2006
  ident: 1364_CR13
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.26.4.1272-1287.2006
  contributor:
    fullname: J Wittmann
– volume: 22
  start-page: 186
  year: 2003
  ident: 1364_CR167
  publication-title: Oncogene.
  doi: 10.1038/sj.onc.1206075
  contributor:
    fullname: YQ Zhou
– volume: 8
  start-page: 1233
  year: 2002
  ident: 1364_CR132
  publication-title: RNA.
  doi: 10.1017/S1355838202028030
  contributor:
    fullname: BJ Lam
– volume: 25
  start-page: 323
  year: 2006
  ident: 1364_CR25
  publication-title: Oncogene.
  doi: 10.1038/sj.onc.1209033
  contributor:
    fullname: MD Ware
– volume: 13
  start-page: 89
  year: 2012
  ident: 1364_CR111
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm3270
  contributor:
    fullname: C Hetz
– volume: 39
  start-page: 910
  year: 2008
  ident: 1364_CR186
  publication-title: Hum Pathol
  doi: 10.1016/j.humpath.2007.10.021
  contributor:
    fullname: IB Rosenwald
– volume: 7
  start-page: 44674
  year: 2017
  ident: 1364_CR189
  publication-title: Sci Rep
  doi: 10.1038/srep44674
  contributor:
    fullname: L Guo
– volume: 36
  start-page: 497
  year: 2008
  ident: 1364_CR80
  publication-title: Biochem Soc Trans
  doi: 10.1042/BST0360497
  contributor:
    fullname: O Mühlemann
– volume: 47
  start-page: 5293
  year: 2019
  ident: 1364_CR129
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkz193
  contributor:
    fullname: D Pervouchine
– volume: 75
  start-page: 78
  year: 2018
  ident: 1364_CR18
  publication-title: Semin Cell Dev Biol
  doi: 10.1016/j.semcdb.2017.08.053
  contributor:
    fullname: S Nasif
– volume: 6
  start-page: 1197
  year: 2000
  ident: 1364_CR131
  publication-title: RNA.
  doi: 10.1017/S1355838200000960
  contributor:
    fullname: BR Graveley
– volume: 26
  start-page: 1820
  year: 2007
  ident: 1364_CR34
  publication-title: EMBO J
  doi: 10.1038/sj.emboj.7601628
  contributor:
    fullname: W Chan
– volume: 126
  start-page: 3058
  year: 2016
  ident: 1364_CR28
  publication-title: J Clin Invest
  doi: 10.1172/JCI86508
  contributor:
    fullname: J Lu
– volume: 7
  start-page: 7329
  year: 2016
  ident: 1364_CR191
  publication-title: Oncotarget.
  doi: 10.18632/oncotarget.6940
  contributor:
    fullname: H Zeng
– volume: 75
  start-page: 324
  year: 2019
  ident: 1364_CR85
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2019.05.008
  contributor:
    fullname: TA Hoek
– volume: 12
  start-page: 4271
  year: 2020
  ident: 1364_CR153
  publication-title: Cancer Manag Res
  doi: 10.2147/CMAR.S244486
  contributor:
    fullname: X Bao
– volume: 27
  start-page: 4255
  year: 2008
  ident: 1364_CR155
  publication-title: Oncogene.
  doi: 10.1038/onc.2008.62
  contributor:
    fullname: R Karam
– volume: 14
  start-page: 2173
  year: 2000
  ident: 1364_CR134
  publication-title: Genes Dev
  doi: 10.1101/gad.819900
  contributor:
    fullname: QM Mitrovich
– volume: 42
  start-page: 2194
  year: 2017
  ident: 1364_CR195
  publication-title: Cell Physiol Biochem
  doi: 10.1159/000479994
  contributor:
    fullname: L Li
– volume: 1
  start-page: 209
  year: 1992
  ident: 1364_CR140
  publication-title: Nat Genet
  doi: 10.1038/ng0692-209
  contributor:
    fullname: PJ Rosenfeld
– volume: 109
  start-page: 5422
  year: 2007
  ident: 1364_CR23
  publication-title: Blood.
  doi: 10.1182/blood-2006-11-057208
  contributor:
    fullname: M Pinyol
– volume: 109
  start-page: 21313
  year: 2012
  ident: 1364_CR35
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1219725110
  contributor:
    fullname: A Alexandrov
– volume: 623
  start-page: 190
  year: 2007
  ident: 1364_CR117
  publication-title: Adv Exp Med Biol
  doi: 10.1007/978-0-387-77374-2_12
  contributor:
    fullname: LF Lareau
– volume: 17
  start-page: 1103
  year: 2012
  ident: 1364_CR10
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2011.163
  contributor:
    fullname: LS Nguyen
– volume: 29
  start-page: 65
  year: 2008
  ident: 1364_CR20
  publication-title: Hum Mutat
  doi: 10.1002/humu.20590
  contributor:
    fullname: O Anczuków
– volume: 21
  start-page: 4007
  year: 2012
  ident: 1364_CR200
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/dds223
  contributor:
    fullname: R Kayali
– volume: 20
  start-page: 406
  year: 2019
  ident: 1364_CR158
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/s41580-019-0126-2
  contributor:
    fullname: T Kurosaki
– volume: S0168-9525
  start-page: 30307
  year: 2020
  ident: 1364_CR211
  publication-title: Trends Genet
  contributor:
    fullname: F Supek
– volume: 465
  start-page: 227
  year: 2010
  ident: 1364_CR220
  publication-title: Nature.
  doi: 10.1038/nature08999
  contributor:
    fullname: F Pastor
– volume: 9
  start-page: 1
  year: 2019
  ident: 1364_CR190
  publication-title: Sci Rep
  doi: 10.1038/s41598-018-37186-2
  contributor:
    fullname: Z Shi
– volume: 74
  start-page: 3509
  year: 2017
  ident: 1364_CR8
  publication-title: Cell Mol Life Sci
  doi: 10.1007/s00018-017-2537-6
  contributor:
    fullname: AE Goetz
– volume: 515
  start-page: 568
  year: 2014
  ident: 1364_CR216
  publication-title: Nature.
  doi: 10.1038/nature13954
  contributor:
    fullname: PC Tumeh
– volume: 11
  start-page: 565
  year: 2010
  ident: 1364_CR130
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-11-565
  contributor:
    fullname: NJ McGlincy
– volume: 16
  start-page: 587
  year: 2004
  ident: 1364_CR71
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2004.10.013
  contributor:
    fullname: L Unterholzner
– volume: 76
  start-page: 51
  year: 2007
  ident: 1364_CR123
  publication-title: Annu Rev Biochem
  doi: 10.1146/annurev.biochem.76.050106.093909
  contributor:
    fullname: Y-F Chang
– volume: 12
  year: 2016
  ident: 1364_CR95
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1005863
  contributor:
    fullname: J Bao
– volume: 51
  start-page: 1645
  year: 2019
  ident: 1364_CR219
  publication-title: Nat Genet
  doi: 10.1038/s41588-019-0517-5
  contributor:
    fullname: RGH Lindeboom
– volume: 13
  start-page: 100738
  year: 2020
  ident: 1364_CR215
  publication-title: Transl Oncol
  doi: 10.1016/j.tranon.2019.12.010
  contributor:
    fullname: L Barrueto
– volume: 6
  start-page: 685
  year: 2014
  ident: 1364_CR113
  publication-title: EMBO Mol Med
  doi: 10.1002/emmm.201303347
  contributor:
    fullname: YS Oren
– volume: 14
  start-page: 1199
  year: 2005
  ident: 1364_CR145
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddi131
  contributor:
    fullname: EC Wolstencroft
– volume: 276
  start-page: 47329
  year: 2001
  ident: 1364_CR172
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M107666200
  contributor:
    fullname: CC Chen
– volume: 22
  start-page: 1754
  year: 2015
  ident: 1364_CR196
  publication-title: Cell Death Differ
  doi: 10.1038/cdd.2015.18
  contributor:
    fullname: J Jia
– volume: 34
  start-page: 1630
  year: 2015
  ident: 1364_CR87
  publication-title: EMBO J
  doi: 10.15252/embj.201489947
  contributor:
    fullname: T Li
– volume: 184
  start-page: 1781
  year: 1996
  ident: 1364_CR207
  publication-title: J Exp Med
  doi: 10.1084/jem.184.5.1781
  contributor:
    fullname: MF Van Den Broek
– volume: 23
  start-page: 1091
  year: 2009
  ident: 1364_CR44
  publication-title: Genes Dev
  doi: 10.1101/gad.1767209
  contributor:
    fullname: A Yamashita
– volume: 24
  start-page: 1403
  year: 2014
  ident: 1364_CR176
  publication-title: Cell Res
  doi: 10.1038/cr.2014.151
  contributor:
    fullname: X Zhao
– volume: 79
  start-page: 5785
  year: 2019
  ident: 1364_CR183
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-18-2868
  contributor:
    fullname: F Li
– volume: 94
  start-page: 551
  year: 2001
  ident: 1364_CR210
  publication-title: Int J Cancer
  doi: 10.1002/ijc.1491
  contributor:
    fullname: FH Saleh
– volume: 20
  start-page: 65
  year: 2005
  ident: 1364_CR74
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2005.08.012
  contributor:
    fullname: NH Gehring
– volume: 85
  start-page: 1301
  year: 2007
  ident: 1364_CR170
  publication-title: J Mol Med
  doi: 10.1007/s00109-007-0281-3
  contributor:
    fullname: MC Brahimi-Horn
– volume: 11
  start-page: 2805
  year: 2002
  ident: 1364_CR22
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/11.23.2805
  contributor:
    fullname: L Perrin-Vidoz
– volume: 62
  start-page: 335
  year: 2016
  ident: 1364_CR181
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2016.03.021
  contributor:
    fullname: S Lin
– volume: 22
  start-page: 9
  year: 2021
  ident: 1364_CR222
  publication-title: Genome Biol
  doi: 10.1186/s13059-020-02240-8
  contributor:
    fullname: M Oka
– volume: 7
  start-page: 70
  year: 2018
  ident: 1364_CR157
  publication-title: Oncogenesis
  doi: 10.1038/s41389-018-0079-x
  contributor:
    fullname: A Bokhari
– volume: 48
  start-page: 1112
  year: 2016
  ident: 1364_CR21
  publication-title: Nat Genet
  doi: 10.1038/ng.3664
  contributor:
    fullname: RGH Lindeboom
– volume: 165
  start-page: 382
  year: 2016
  ident: 1364_CR47
  publication-title: Cell.
  doi: 10.1016/j.cell.2016.02.046
  contributor:
    fullname: EY Shum
– volume: 20
  start-page: 355
  year: 2006
  ident: 1364_CR42
  publication-title: Genes Dev
  doi: 10.1101/gad.1389006
  contributor:
    fullname: I Kashima
– volume: 505
  start-page: 117
  year: 2014
  ident: 1364_CR179
  publication-title: Nature.
  doi: 10.1038/nature12730
  contributor:
    fullname: X Wang
– volume: 6
  year: 2008
  ident: 1364_CR54
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.0060092
  contributor:
    fullname: AB Eberle
– volume: 16
  start-page: 49
  year: 2009
  ident: 1364_CR63
  publication-title: Nat Struct Mol Biol
  doi: 10.1038/nsmb.1530
  contributor:
    fullname: AB Eberle
– ident: 1364_CR77
  doi: 10.1016/j.celrep.2018.04.039
– volume: 513
  start-page: 1076
  year: 2019
  ident: 1364_CR193
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2019.04.054
  contributor:
    fullname: V Tano
– volume: 429
  start-page: 575
  year: 2004
  ident: 1364_CR69
  publication-title: Nature.
  doi: 10.1038/nature02559
  contributor:
    fullname: D Gatfield
– volume: 23
  start-page: 189
  year: 2017
  ident: 1364_CR17
  publication-title: RNA.
  doi: 10.1261/rna.059055.116
  contributor:
    fullname: M Colombo
– volume: 38
  start-page: 548
  year: 2010
  ident: 1364_CR59
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkp908
  contributor:
    fullname: AV Kononenko
– volume: 36
  start-page: 1073
  year: 2004
  ident: 1364_CR14
  publication-title: Nat Genet
  doi: 10.1038/ng1429
  contributor:
    fullname: JT Mendell
– volume: 178
  start-page: 1145
  year: 2007
  ident: 1364_CR201
  publication-title: J Cell Biol
  doi: 10.1083/jcb.200611086
  contributor:
    fullname: S Durand
– volume: 11
  start-page: 1101
  year: 2001
  ident: 1364_CR188
  publication-title: Thyroid.
  doi: 10.1089/10507250152740939
  contributor:
    fullname: S Wang
– volume: 17
  start-page: 537
  year: 2005
  ident: 1364_CR68
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2005.01.010
  contributor:
    fullname: N Fukuhara
– volume: 21
  start-page: 370
  year: 1999
  ident: 1364_CR136
  publication-title: Nat Genet
  doi: 10.1038/7701
  contributor:
    fullname: E Jouanguy
– volume: 42
  start-page: 722
  year: 2010
  ident: 1364_CR161
  publication-title: Nat Genet
  doi: 10.1038/ng.621
  contributor:
    fullname: T Ernst
– volume: 17
  start-page: 3484
  year: 1998
  ident: 1364_CR29
  publication-title: EMBO J
  doi: 10.1093/emboj/17.12.3484
  contributor:
    fullname: R Thermann
– volume: 29
  start-page: 2082
  year: 2010
  ident: 1364_CR150
  publication-title: EMBO J
  doi: 10.1038/emboj.2010.81
  contributor:
    fullname: J Ye
– volume: 19
  start-page: 6860
  year: 2000
  ident: 1364_CR32
  publication-title: EMBO J
  doi: 10.1093/emboj/19.24.6860
  contributor:
    fullname: H Le Hir
– volume: 16
  start-page: 403
  year: 2014
  ident: 1364_CR114
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2014.08.007
  contributor:
    fullname: G Balistreri
– volume: 95
  start-page: 7556
  year: 1998
  ident: 1364_CR206
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.95.13.7556
  contributor:
    fullname: DH Kaplan
– volume: 6
  start-page: 1
  year: 2000
  ident: 1364_CR53
  publication-title: RNA.
  doi: 10.1017/S1355838200991660
  contributor:
    fullname: X Sun
– volume: 8
  year: 2013
  ident: 1364_CR91
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0055684
  contributor:
    fullname: H Tani
– volume: 9
  start-page: 1370
  year: 2012
  ident: 1364_CR9
  publication-title: RNA Biol
  doi: 10.4161/rna.22360
  contributor:
    fullname: H Tani
– volume: 142
  start-page: 352
  year: 2015
  ident: 1364_CR94
  publication-title: Development.
  contributor:
    fullname: J Bao
– volume: 19
  start-page: 6860
  year: 2000
  ident: 1364_CR38
  publication-title: EMBO J
  doi: 10.1093/emboj/19.24.6860
  contributor:
    fullname: H Le Hir
– volume: 44
  start-page: 1255
  year: 2016
  ident: 1364_CR214
  publication-title: Immunity.
  doi: 10.1016/j.immuni.2016.06.001
  contributor:
    fullname: JM Pitt
– volume: 270
  start-page: 10878
  year: 1995
  ident: 1364_CR24
  publication-title: J Biol Chem
  doi: 10.1074/jbc.270.18.10878
  contributor:
    fullname: JC Reddy
– volume: 21
  start-page: 1
  year: 2020
  ident: 1364_CR118
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms21249424
  contributor:
    fullname: JF García-Moreno
– volume: 8
  start-page: 39101
  year: 2017
  ident: 1364_CR169
  publication-title: Oncotarget.
  doi: 10.18632/oncotarget.16603
  contributor:
    fullname: Y Ling
– volume: 45
  start-page: 11356
  year: 2017
  ident: 1364_CR177
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkx778
  contributor:
    fullname: M Bartosovic
– volume: 107
  start-page: 10050
  year: 2010
  ident: 1364_CR43
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1000993107
  contributor:
    fullname: G Buchwald
– volume: 34
  start-page: 164
  year: 2016
  ident: 1364_CR205
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt.3427
  contributor:
    fullname: TT Nomakuchi
– volume: 514
  start-page: 1
  year: 2013
  ident: 1364_CR121
  publication-title: Gene.
  doi: 10.1016/j.gene.2012.07.083
  contributor:
    fullname: O Kelemen
– volume: 17
  start-page: 738
  year: 2017
  ident: 1364_CR168
  publication-title: BMC Cancer
  doi: 10.1186/s12885-017-3747-x
  contributor:
    fullname: S Krishnaswamy
– volume: 762
  start-page: 52
  year: 2014
  ident: 1364_CR7
  publication-title: Mutat Res Rev Mutat Res
  doi: 10.1016/j.mrrev.2014.05.001
  contributor:
    fullname: JN Miller
– volume: 15
  start-page: 85
  year: 2008
  ident: 1364_CR49
  publication-title: Nat Struct Mol Biol
  doi: 10.1038/nsmb1330
  contributor:
    fullname: H Chamieh
– volume: 47
  start-page: 139
  year: 2013
  ident: 1364_CR4
  publication-title: Annu Rev Genet
  doi: 10.1146/annurev-genet-111212-133424
  contributor:
    fullname: MW-L Popp
– volume: 22
  start-page: 1105
  year: 2014
  ident: 1364_CR51
  publication-title: Structure.
  doi: 10.1016/j.str.2014.05.015
  contributor:
    fullname: R Melero
– volume: 43
  start-page: 950
  year: 2011
  ident: 1364_CR76
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2011.06.031
  contributor:
    fullname: L Huang
– volume: 20
  start-page: 1785
  year: 2001
  ident: 1364_CR126
  publication-title: EMBO J
  doi: 10.1093/emboj/20.7.1785
  contributor:
    fullname: A Sureau
– volume: 7
  start-page: 58
  year: 2012
  ident: 1364_CR198
  publication-title: Orphanet J Rare Dis
  doi: 10.1186/1750-1172-7-58
  contributor:
    fullname: S Gonzalez-Hilarion
– volume: 17
  start-page: 2108
  year: 2011
  ident: 1364_CR16
  publication-title: RNA.
  doi: 10.1261/rna.030247.111
  contributor:
    fullname: H Yepiskoposyan
– volume: 8
  start-page: 1845
  year: 2014
  ident: 1364_CR45
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2014.08.020
  contributor:
    fullname: N Hug
– volume: 13
  start-page: 462
  year: 2006
  ident: 1364_CR75
  publication-title: Nat Struct Mol Biol
  doi: 10.1038/nsmb1081
  contributor:
    fullname: M Bühler
– volume: 335
  start-page: 1956
  year: 1996
  ident: 1364_CR137
  publication-title: N Engl J Med
  doi: 10.1056/NEJM199612263352604
  contributor:
    fullname: E Jouanguy
– volume: 2015
  start-page: 417281
  year: 2015
  ident: 1364_CR148
  publication-title: Inflamm
  doi: 10.1155/2015/417281
  contributor:
    fullname: C Giampietri
– volume: 286
  start-page: 40038
  year: 2011
  ident: 1364_CR107
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M111.266361
  contributor:
    fullname: D Wang
– volume: 28
  start-page: 4320
  year: 2008
  ident: 1364_CR133
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.00361-08
  contributor:
    fullname: AL Saltzman
– volume: 26
  start-page: 2670
  year: 2007
  ident: 1364_CR98
  publication-title: EMBO J
  doi: 10.1038/sj.emboj.7601712
  contributor:
    fullname: YK Kim
– volume: 10
  start-page: 1
  year: 2019
  ident: 1364_CR112
  publication-title: Nat Commun
  doi: 10.1038/s41467-019-10606-1
  contributor:
    fullname: Y Gordiyenko
– volume: 88
  start-page: 6481
  year: 1991
  ident: 1364_CR141
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.88.15.6481
  contributor:
    fullname: CH Sung
– volume: 20
  start-page: 651
  year: 2020
  ident: 1364_CR213
  publication-title: Nat Rev Immunol
  doi: 10.1038/s41577-020-0306-5
  contributor:
    fullname: AD Waldman
– volume: 9
  start-page: 555
  year: 2014
  ident: 1364_CR65
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2014.09.012
  contributor:
    fullname: V Boehm
– volume: 21
  start-page: 3536
  year: 2002
  ident: 1364_CR37
  publication-title: EMBO J
  doi: 10.1093/emboj/cdf345
  contributor:
    fullname: F Lejeune
– volume: 16
  start-page: 2598
  year: 2017
  ident: 1364_CR218
  publication-title: Mol Cancer Ther
  doi: 10.1158/1535-7163.MCT-17-0386
  contributor:
    fullname: AM Goodman
– volume: 20
  start-page: 881
  year: 2005
  ident: 1364_CR166
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2005.10.026
  contributor:
    fullname: C Ghigna
– volume: 22
  start-page: 1816
  year: 2013
  ident: 1364_CR103
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddt035
  contributor:
    fullname: LS Nguyen
– volume: 19
  start-page: 6710
  year: 1999
  ident: 1364_CR79
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.19.10.6710
  contributor:
    fullname: MJ Lelivelt
– volume: 89
  start-page: 1149
  year: 2011
  ident: 1364_CR143
  publication-title: J Mol Med
  doi: 10.1007/s00109-011-0787-6
  contributor:
    fullname: SM Rowe
– volume: 5
  start-page: 89
  year: 2004
  ident: 1364_CR41
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm1310
  contributor:
    fullname: LE Maquat
– volume: 106
  start-page: 607
  year: 2001
  ident: 1364_CR36
  publication-title: Cell.
  doi: 10.1016/S0092-8674(01)00475-5
  contributor:
    fullname: Y Ishigaki
– volume: 28
  start-page: 3729
  year: 2008
  ident: 1364_CR105
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.02284-07
  contributor:
    fullname: LB Gardner
– volume: 86
  start-page: 7530
  year: 2012
  ident: 1364_CR115
  publication-title: J Virol
  doi: 10.1128/JVI.07021-11
  contributor:
    fullname: V Mocquet
– volume: 2013
  start-page: 358015
  year: 2013
  ident: 1364_CR92
  publication-title: Biomed Res Int
  doi: 10.1155/2013/358015
  contributor:
    fullname: M Mourtada-Maarabouni
– volume: 8
  start-page: 9200
  year: 2017
  ident: 1364_CR173
  publication-title: Oncotarget.
  doi: 10.18632/oncotarget.13677
  contributor:
    fullname: YT Huang
– volume: 446
  start-page: 926
  year: 2007
  ident: 1364_CR125
  publication-title: Nature.
  doi: 10.1038/nature05676
  contributor:
    fullname: LF Lareau
– volume: 6
  start-page: 6632
  year: 2015
  ident: 1364_CR197
  publication-title: Nat Commun
  doi: 10.1038/ncomms7632
  contributor:
    fullname: MW Popp
– volume: 25
  start-page: 153
  year: 2011
  ident: 1364_CR48
  publication-title: Genes Dev
  doi: 10.1101/gad.606911
  contributor:
    fullname: E Arias-Palomo
– volume: 7
  start-page: 10585
  year: 2016
  ident: 1364_CR46
  publication-title: Nat Commun
  doi: 10.1038/ncomms10585
  contributor:
    fullname: R Melero
– ident: 1364_CR60
  doi: 10.1261/rna.201406
– volume: 36
  start-page: 2928
  year: 2017
  ident: 1364_CR73
  publication-title: EMBO J
  doi: 10.15252/embj.201798063
  contributor:
    fullname: O Mühlemann
– volume: 97
  start-page: 2059
  year: 2001
  ident: 1364_CR138
  publication-title: Blood.
  doi: 10.1182/blood.V97.7.2059
  contributor:
    fullname: R Schneppenheim
– volume: 74
  start-page: 3104
  year: 2014
  ident: 1364_CR204
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-13-2235
  contributor:
    fullname: L Martin
– volume: 22
  start-page: 1381
  year: 2008
  ident: 1364_CR11
  publication-title: Genes Dev
  doi: 10.1101/gad.468808
  contributor:
    fullname: J Weischenfeldt
– volume: 50
  start-page: 805
  year: 2014
  ident: 1364_CR199
  publication-title: Am J Respir Cell Mol Biol
  doi: 10.1165/rcmb.2013-0282OC
  contributor:
    fullname: X Xue
– volume: 134
  start-page: 1823
  year: 2007
  ident: 1364_CR96
  publication-title: Development.
  doi: 10.1242/dev.000018
  contributor:
    fullname: JMA Turner
– volume: 48
  start-page: 44
  year: 2018
  ident: 1364_CR2
  publication-title: Curr Opin Genet Dev
  doi: 10.1016/j.gde.2017.10.007
  contributor:
    fullname: MW Popp
– volume: 18
  start-page: 315
  year: 2008
  ident: 1364_CR40
  publication-title: Trends Cell Biol
  doi: 10.1016/j.tcb.2008.04.005
  contributor:
    fullname: L Stalder
– volume: 39
  start-page: 1127
  year: 2007
  ident: 1364_CR102
  publication-title: Nat Genet
  doi: 10.1038/ng2100
  contributor:
    fullname: PS Tarpey
– volume: 17
  start-page: 100
  year: 2001
  ident: 1364_CR119
  publication-title: Trends Genet
  doi: 10.1016/S0168-9525(00)02176-4
  contributor:
    fullname: BR Graveley
– volume: 5
  year: 2010
  ident: 1364_CR93
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0011650
  contributor:
    fullname: LA Thoren
– volume: 27
  start-page: 543
  year: 1981
  ident: 1364_CR6
  publication-title: Cell.
  doi: 10.1016/0092-8674(81)90396-2
  contributor:
    fullname: LE Maquat
– volume: 5
  year: 2016
  ident: 1364_CR90
  publication-title: Elife.
  doi: 10.7554/eLife.12876
  contributor:
    fullname: JO Nelson
– volume: 12
  start-page: 1439
  year: 2003
  ident: 1364_CR15
  publication-title: Mol Cell
  doi: 10.1016/S1097-2765(03)00446-5
  contributor:
    fullname: F He
– volume: 91
  start-page: 168
  year: 2017
  ident: 1364_CR1
  publication-title: Int J Biochem Cell Biol
  doi: 10.1016/j.biocel.2017.07.013
  contributor:
    fullname: PJ da Costa
– volume: 42
  start-page: 665
  year: 2010
  ident: 1364_CR162
  publication-title: Nat Genet
  doi: 10.1038/ng.620
  contributor:
    fullname: G Nikoloski
– volume: 16
  start-page: 747
  year: 2009
  ident: 1364_CR78
  publication-title: Nat Struct Mol Biol
  doi: 10.1038/nsmb.1612
  contributor:
    fullname: W-K Chan
– volume: 163
  start-page: 999
  year: 2015
  ident: 1364_CR178
  publication-title: Cell.
  doi: 10.1016/j.cell.2015.10.012
  contributor:
    fullname: KD Meyer
– volume: 1
  start-page: 447
  year: 1994
  ident: 1364_CR208
  publication-title: Immunity.
  doi: 10.1016/1074-7613(94)90087-6
  contributor:
    fullname: AS Dighe
– volume: 100
  start-page: 189
  year: 2003
  ident: 1364_CR122
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0136770100
  contributor:
    fullname: BP Lewis
– volume: 270
  start-page: 8936
  year: 1995
  ident: 1364_CR84
  publication-title: J Biol Chem
  doi: 10.1074/jbc.270.15.8936
  contributor:
    fullname: CC Oliveira
– volume: 16
  start-page: 665
  year: 2015
  ident: 1364_CR3
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm4063
  contributor:
    fullname: S Lykke-Andersen
– volume: 76
  start-page: 5134
  year: 1979
  ident: 1364_CR5
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.76.10.5134
  contributor:
    fullname: R Losson
– volume: 27
  start-page: 617
  year: 2015
  ident: 1364_CR160
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2015.04.006
  contributor:
    fullname: E Kim
– volume: 463
  start-page: 457
  year: 2010
  ident: 1364_CR120
  publication-title: Nature.
  doi: 10.1038/nature08909
  contributor:
    fullname: TW Nilsen
– volume: 485
  start-page: 201
  year: 2012
  ident: 1364_CR175
  publication-title: Nature.
  doi: 10.1038/nature11112
  contributor:
    fullname: D Dominissini
– volume: 9
  start-page: 989
  year: 2019
  ident: 1364_CR164
  publication-title: Front Oncol
  doi: 10.3389/fonc.2019.00989
  contributor:
    fullname: W Yu
– volume: 403
  start-page: 246
  year: 2017
  ident: 1364_CR147
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2017.06.021
  contributor:
    fullname: L Cao
– volume: 12
  start-page: 675
  year: 2003
  ident: 1364_CR70
  publication-title: Mol Cell
  doi: 10.1016/S1097-2765(03)00349-6
  contributor:
    fullname: F Lejeune
– volume: 33
  start-page: 2128
  year: 2013
  ident: 1364_CR192
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.00174-13
  contributor:
    fullname: J Wengrod
– volume: 270
  start-page: 28995
  year: 1995
  ident: 1364_CR30
  publication-title: J Biol Chem
  doi: 10.1074/jbc.270.48.28995
  contributor:
    fullname: MS Carter
– volume: 20
  start-page: 961
  year: 2014
  ident: 1364_CR202
  publication-title: Nat Med
  doi: 10.1038/nm.3620
  contributor:
    fullname: A Nickless
– volume: 98
  start-page: 1080
  year: 2003
  ident: 1364_CR184
  publication-title: Cancer.
  doi: 10.1002/cncr.11619
  contributor:
    fullname: IB Rosenwald
– volume: 20
  start-page: 8215
  year: 2001
  ident: 1364_CR156
  publication-title: Oncogene.
  doi: 10.1038/sj.onc.1205033
  contributor:
    fullname: S Fan
– volume: 27
  start-page: 736
  year: 2008
  ident: 1364_CR55
  publication-title: EMBO J
  doi: 10.1038/emboj.2008.17
  contributor:
    fullname: PV Ivanov
– volume: 28
  start-page: 2498
  year: 2014
  ident: 1364_CR67
  publication-title: Genes Dev
  doi: 10.1101/gad.246538.114
  contributor:
    fullname: S Lykke-Andersen
– volume: 23
  start-page: 378
  year: 2017
  ident: 1364_CR108
  publication-title: RNA.
  doi: 10.1261/rna.058040.116
  contributor:
    fullname: Z Li
– volume: 100
  start-page: 1337
  year: 2007
  ident: 1364_CR171
  publication-title: J Cell Biochem
  doi: 10.1002/jcb.21194
  contributor:
    fullname: Y Chen
– volume: 42
  start-page: 500
  year: 2011
  ident: 1364_CR100
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2011.04.018
  contributor:
    fullname: IG Bruno
– volume: 27
  start-page: 471
  year: 2008
  ident: 1364_CR81
  publication-title: EMBO J
  doi: 10.1038/sj.emboj.7601977
  contributor:
    fullname: SA Bin
– volume: 6
  year: 2008
  ident: 1364_CR57
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.0060111
  contributor:
    fullname: G Singh
– volume: 98
  start-page: 643
  year: 2016
  ident: 1364_CR89
  publication-title: Am J Hum Genet
  doi: 10.1016/j.ajhg.2016.02.010
  contributor:
    fullname: R Shaheen
– volume: 34
  start-page: 4211
  year: 2015
  ident: 1364_CR106
  publication-title: Oncogene.
  doi: 10.1038/onc.2014.352
  contributor:
    fullname: L Martin
– volume: 106
  start-page: 249
  year: 2000
  ident: 1364_CR139
  publication-title: Hum Genet
  contributor:
    fullname: DS Millar
– volume: 69
  start-page: 2082
  year: 2009
  ident: 1364_CR174
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-08-1997
  contributor:
    fullname: M Hirschfeld
– volume: 10
  start-page: 51
  year: 2006
  ident: 1364_CR149
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2006.06.001
  contributor:
    fullname: K Degenhardt
– volume: 6
  start-page: 7581
  year: 2015
  ident: 1364_CR61
  publication-title: Nat Commun
  doi: 10.1038/ncomms8581
  contributor:
    fullname: F Fiorini
– volume: 130
  start-page: 3009
  year: 2017
  ident: 1364_CR203
  publication-title: J Cell Sci
  doi: 10.1242/jcs.198176
  contributor:
    fullname: J Jia
SSID ssj0017874
Score 2.5399122
SecondaryResourceType review_article
Snippet Nonsense-mediated decay (NMD) was first described as a quality-control mechanism that targets and rapidly degrades aberrant mRNAs carrying premature...
Abstract Nonsense-mediated decay (NMD) was first described as a quality-control mechanism that targets and rapidly degrades aberrant mRNAs carrying premature...
SourceID doaj
pubmedcentral
proquest
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage 72
SubjectTerms Biomarker
Cancer
Cancer therapy
Cell cycle
Codons
Gene expression
Gene regulation
Immunotherapy
Kinases
Mutation
Neoantigen
Nonsense-mediated RNA decay (NMD)
Peptides
Phosphorylation
Proteins
Quality control
Review
Tumor cells
Tumor suppressor gene
Tumorigenesis
SummonAdditionalLinks – databaseName: Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEB5KoKWX0m5eTtOgQG9FxJYl2b4EktAlBLKH0kBuQk-6FydkN4f8-8zI3iUbArkUfJKFkefTaL5hHgL4qYKwDg89LrRKXKbKos61iSP1di7F1DQd1Q5fz_Tljby6VbcvrvqinLChPfAguJOuRQrsQh3Qskhl8ZxIrhLRS-VKZdPQbLtSK2dqjB_gNpSrEplWnyzQqkmKV5LrXGvJyw0zlLv1v0UxX2dKvjA906_wZeSM7GxY6zf4EPsJfBxukXyawKfrMT6-DaczSo7Gh-eKEGST7M_sjIXo7ROzfWDz5YK5-T35s4xMGsHC5j3zBP7DDtxMf_-9uOTjDQncq65cci99F0MVmiSSTlVnfS0tDUTRqFB77ahyFRlgoLxogYC5JqDNIiB8kK7eha3-ro_7wFxdWbRcsnKa9Fp1Gqlc7iYmnLTKFvBrJTBzPzTCMNmBaLUZxGtQvCaL15QFnJNM1zOpiXUeQGjNCK15D9oCDleImFGzFkYodBFVqbu6gOP1a9QJCnTYPt495jnoqeFxg5_YGwBcr6RGQqilVgU0G9BuLHXzTT__l_tut0iXmkYd_I9_-w6fRd6OkovuELaWD4_xB9KbpTvKO_kZx0D3iQ
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3daxQxEB-0peKLaFt1tUoE3yR0N5tkd1-UVlqK0EOKhb6FfLb3snfeXR_63zuT3Ts9EWGfstklzOdvMskMwEcVhHVo9LjQKnGZKos61yaO0Nu5FFPTdHR3-HKiL67ltxt1M264LcdjlWubmA11mHnaIz8WCkMDVequ_jL_yalrFGVXxxYaj2FXVJLStLunZ5PvV5s8AoqjXF-VafXxEr2bpLwlhdC1lrzccke5av-_oObfJyb_cEHnz-HZiB3ZycDsF_Ao9vuwN3STfNiHJ5djnvwAPk_okDQ-PN8MQVTJriYnLERvH5jtA5uulsxN5xTXMnJtxB427ZknIVgcwvX52Y-vF3zslMC96soV99J3MVShSSLpVHXW19LSQBSNCrXXjm6wIhIMdD5aIONcE9B3EUN8kK5-CTv9rI-vgbm6sujBZOU06bfqNEK6XFVMOGmVLeDTmmBmPhTEMDmQaLUZyGuQvCaT15QFnBJNNzOpmHUemC1uzagbpmvxaxfqgOBBKouuILlKRC-VK5VNuoCjNUfMqGFL81seCviweY26QQkP28fZfZ6DERuaHfzFq4GBm5XUCAy11KqAZou1W0vdftNP73L97RZhU9OoN_9f1lt4KrKgSS66I9hZLe7jOwQwK_d-lNJfS0DvrQ
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LixNBEC6WFcWL6PoaXaUFbzKa6dfMHFRWcVmE5CAG9tb0UwMyWZMsmH9vVc9MNBKEOfVjaOrR9RXVVQXwUgVuHV56JdcqlTJVFnWuSSVCb-dSTHXdUu7wdKYv5vLzpbo8grHd0UDA9UHXjvpJzVc_Xv_6uX2PCv82K3yj36zRZkmKRpJjLLQs0YW_waWQJPFT-SeqgMIpx8SZg_v2jFOu4X8IeP77fvIvg3R-F-4MSJKd9ay_B0exO4GbfW_J7Qncmg5R8_vwbkZPpvErc54IYkz2ZXbGQvR2y2wX2GKzZm5xRaRgZOiIWWzRMU8isXoA8_NPXz9elEPfhNKrdrIpvfRtDFWoE086Va31QloaiLxWQXjtKJ8VcWGg19Ic2ejqgJaM2OODdOIhHHfLLj4G5kRl0Z7JymnSdtVqBHi5xhh30ipbwKuRYOaqL49hslvRaNOT1yB5TSavmRTwgWi6W0mlrfPAcvXNDJpi2gZ3uyACQgmpLBqG5CoevVRuomzSBZyOHDGjuBiu0HFUE92KAl7splFTKPxhu7i8zmvQf8NLCH_xqGfg7iQCYaKWWhVQ77F276j7M93ie67G3SCIqmv15P_Hegq3eRY0WfL2FI43q-v4DOHMxj3PMvobYuXxbA
  priority: 102
  providerName: Scholars Portal
Title Nonsense-mediated RNA decay and its bipolar function in cancer
URI https://www.ncbi.nlm.nih.gov/pubmed/33926465
https://www.proquest.com/docview/2528950693
https://search.proquest.com/docview/2520860516
https://pubmed.ncbi.nlm.nih.gov/PMC8082775
https://doaj.org/article/98118bd3d81845aeacfb12ec45b05af6
Volume 20
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9swED_ajo29jK378tYFDfY23MT6tF8GaWkpgYTSrZA3oQ9rM6xOSNKH_vc7KXZoxp4GxgZbNuLupN_vrLsTwBfhqbE46eVUipDzUBgcc2XIkXpbG-qgVBVzh6czeXXLJ3MxPwDR58KkoH1nm9P2991p2_xKsZXLOzfs48SG19PzEnFLKTE8hEPFWO-id0sHaIG8z44p5XCNgMbjUmX0mpnkedz7jSErkDwCyiMwSjX7_0U0_46XfARAly_hRcccyXjbw1dwULfH8HS7l-TDMTybdqvkr-HbLIZI45GnvBDklORmNia-duaBmNaTZrMmtllGr5ZEYIvKIU1LXDSB1Ru4vbz4cX6Vd_sk5E5Uo03uuKtqX3gVaJChqIxj3MQbNVXCMydtzF9FHuhjdDRFtVnlEbmiOpznlr2Fo3bR1u-BWFYYxC9eWBlHt6gkErpUU4xaboTJ4GsvML3clsPQyY0opd5KWqOkdZK0HmVwFmW6axlLWacbi9VP3SlUVyW-bT3zSB24MAgEwRa0dlzYkTBBZnDSa0R342utqUBHUYxkxTL4vHuMIyMud5i2XtynNuiv4aSDn3i3VeCuJ70BZKD2VLvX1f0naIyp-nZnfB_--82P8Jwmc-Q5rU7gaLO6rz8hs9nYAdrzXA3gyXg8-T7B69nF7PpmkP4T4HnKy0Gy9T9t5_0g
link.rule.ids 230,315,733,786,790,870,891,2115,12083,21416,24346,27955,27956,31752,31753,33777,33778,43343,43838,53825,53827
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lj9MwEB7BIh4XBMursICRuCFrE7-SXEALYlVg2wPalXqz_IiXXtLSdg_775lx0kIRQsrJcSJrnt947BmAtzoK59HocWF04iqVDnWuThyht_epTVXV0N3hydSML9TXmZ4NG27r4Vjl1iZmQx0XgfbIj4XG0EAXppEflj85dY2i7OrQQuMm3FJSKpLzarYLuEoURrW9KFOb4zX6NkVZSwqgpVG82HNGuWb_v4Dm3-cl_3BApw_g_oAc2UnP6odwo-0O4XbfS_L6EO5Mhiz5I3g_pSPS-PB8LwQxJfs-PWGxDe6auS6y-WbN_HxJUS0jx0bMYfOOBRKB1WO4OP18_mnMhz4JPOim2PCgQtPGMlZJJJPKxgWpHA20otJRBuPp_iriwEinowWyzVcRPRexI0Tl5RM46BZd-wyYl6VD_6VKb0i7dWMQ0OWaYsIrp90I3m0JZpd9OQybw4ja2J68FslrM3ltMYKPRNPdTCplnQcWq0s7aIZtavzaRxkROijt0BEkX4o2KO0L7ZIZwdGWI3bQr7X9LQ0jeLN7jZpB6Q7XtYurPAfjNTQ6-IunPQN3K5EIC40yegTVHmv3lrr_ppv_yNW3awRNVaWf_39Zr-Hu-HxyZs--TL-9gHsiC53iojmCg83qqn2JUGbjX2V5_QWd4_E0
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB5BERUXHuUVKGAkbiibjWM7yQWpFFblsasKUaniYvkRQwTNrnazh_LrGTvJarfiVCmn2I6SfDP-vpHHY4A33FKlcdKLqeAuZi5V6HOFi1F6a-0ql-el3zs8nYmTM_b5nJ9vHfUVkvaNrkfNn4tRU_8KuZWLC5MMeWLJ6fS4QN7Kc54srEtuwi30WZoPgXq_gIB2yIY9MoVIVkhrzC9Y-tg5Eyz2J8BlqA0E87SyRUmhcv__5ObVrMktGprcgx_DB3TZJ79H61aPzN8rtR2v9YX34W4vTslR1-UB3KiaA7jdHVd5eQD7034h_iG8m_ksbLzisPUEZSv5NjsitjLqkqjGkrpdEV0vfOBMPHd6_EndEOOtbPkIziYfvx-fxP1RDLHh5biNDTNlZVObO-qES0tlMqb8jYrm3GZGaL9FFqWm9QnYFC1D5xbJ0SNuLNPZY9hr5k31FIjOUoUUyVIt_ATCS4GaMZQto5opriJ4O6AhF13FDRkilULIDkaJMMoAoxxH8N4Dtunpq2WHG_PlT9n_UVkWOFrbzKI6YVwh1zid0sowrsdcORHB4QC37F14JSnHWJSPRZlF8HrTjM7nV1RUU83XoQ-GhDiv4SOedNaxeZPBuiLId-xm51V3W9AaQoHvHv1n1x75CvZPP0zk10-zL8_hDg1mz2JaHsJeu1xXL1BHtfpl8Jh_dFMbzg
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Nonsense-mediated+RNA+decay+and+its+bipolar+function+in+cancer&rft.jtitle=Molecular+cancer&rft.au=Nogueira%2C+Gon%C3%A7alo&rft.au=Fernandes%2C+Rafael&rft.au=Garc%C3%ADa-Moreno%2C+Juan+F&rft.au=Rom%C3%A3o%2C+Lu%C3%ADsa&rft.date=2021-04-29&rft.pub=BioMed+Central&rft.eissn=1476-4598&rft.volume=20&rft.spage=1&rft_id=info:doi/10.1186%2Fs12943-021-01364-0
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1476-4598&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1476-4598&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1476-4598&client=summon