TRPC3 Channels Confer Cellular Memory of Recent Neuromuscular Activity

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 101; no. 25; pp. 9387 - 9392
• Main Authors: Rosenberg, Paul, Hawkins, April, Stiber, Jonathan, Shelton, John M., Hutcheson, Kelley, Bassel-Duby, Rhonda, Shin, Dong Min, Yan, Zhen, Williams, R. Sanders, Stevens, Charles F.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 22.06.2004; National Acad Sciences
• Subjects: Animals; Biological Sciences; Calcineurin - physiology; Calcium; Calcium - pharmacology; Cell Line; Cloning, Molecular; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Gene expression; Ion Channels - genetics; Ion Channels - physiology; Kinetics; Medical research; Memory; Mice; Mice, Transgenic; Motor Activity - physiology; Muscle Contraction; Muscle fibers; Muscle Proteins - isolation & purification; Muscle Proteins - metabolism; Muscle, Skeletal - physiology; Muscles; Muscular system; Nerves; Neuromuscular Junction - physiology; Neurons; NFATC Transcription Factors; Nuclear Proteins; Phenotypes; Phosphoproteins - genetics; Phosphoproteins - metabolism; Promoter Regions, Genetic; Skeletal muscle; T lymphocytes; Transcription Factors - genetics; Transcription Factors - metabolism; Transgenic animals; TRPC Cation Channels

Skeletal muscle adapts to different patterns of motor nerve activity by alterations in gene expression that match specialized properties of contraction, metabolism, and muscle mass to changing work demands (muscle plasticity). Calcineurin, a calcium/calmodulin-dependent, serine-threonine protein pho...