Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice - Martinod, Kimberly; Demers, Melanie; Fuchs, Tobias A.; Wong, Siu Ling; Brill, Alexander; Gallant, Maureen; Hu, Jing; Wang, Yanming; Wagner, Denisa D. (Proceedings of the National Academy of Sciences - PNAS, 2013)
Keywords: Animals; Biological Sciences; Bone marrow; Chimeras; Chromatin; Chromatin Assembly and Disassembly; Coagulation; Deoxyribonucleic acid; DNA; drugs; embolism; Health problems; hematopoietic stem cells; hemorrhage; Histones; Histones - genetics; Histones - metabolism; Hydrolases - genetics; Hydrolases - metabolism; inferior vena cava; Leukocytes; Mice; Mice, Knockout; Mortality; Neutrophil Activation; Neutrophils; Neutrophils - enzymology; Neutrophils - pathology; Pathologic constriction; platelet aggregation; Platelet Aggregation - genetics; Platelets; Rodents; Thromboembolism; Thrombosis; Venous thrombosis; Venous Thrombosis - enzymology; Venous Thrombosis - genetics; Venous Thrombosis - pathology; Venous Thrombosis - therapy; nuclear swelling; histone citrullination; programmed cell death; inflammation; venous thromboembolism