Correlation Between Albuminuria and Spontaneous Platelet Microaggregate Formation in Type 2 Diabetic Patients

• Published in: Diabetes care Vol. 32; no. 11; pp. 2062 - 2067
• Main Authors: Araki, Shin-ichi, Matsuno, Hiroyuki, Haneda, Masakazu, Koya, Daisuke, Kanno, Yosuke, Itho, Junko, Kishi, Akio, Isshiki, Keiji, Sugimoto, Toshiro, Maegawa, Hiroshi, Kashiwagi, Atsunori, Uzu, Takashi
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.11.2009
• Subjects: adenosine diphosphate; Adenosine Diphosphate - pharmacology; Aged; agonists; albumins; Albuminuria; Albuminuria - epidemiology; aspirin; Associated diseases and complications; Biological and medical sciences; blood; Blood Flow Velocity; Blood Platelets; Blood Platelets - physiology; Body Mass Index; Cardiovascular disease; cardiovascular diseases; complications; Diabetes; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - urine; Diabetes. Impaired glucose tolerance; Diabetic Angiopathies; Diabetic Angiopathies - epidemiology; drug effects; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; epidemiology; excretion; Female; flow cytometry; genetics; Glycated Hemoglobin; Glycated Hemoglobin A - metabolism; glycoproteins; Humans; Male; Medical sciences; Metabolic diseases; metabolism; Methods; microaggregates; Middle Aged; Miscellaneous; noninsulin-dependent diabetes mellitus; Original Research; P-Selectin; P-Selectin - genetics; patients; pharmacology; Physical examinations; physiology; Platelet Activation; Platelet Aggregation; Platelet Aggregation - drug effects; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Glycoprotein GPIIb-IIIa Complex - genetics; Public health. Hygiene; Public health. Hygiene-occupational medicine; regression analysis; Risk Factors; Shear stress; Stress, Mechanical; Studies; Thrombosis; urine; Waist-Hip Ratio; Endocrinopathy; Kidney disease; Type 2 diabetes; Human; Urine; Correlation; Urinary system disease; Nutrition; Spontaneous; Albumin; Patient; Metabolic diseases; Concomitant disease; Platelet; Diabetic nephropathy; Formation; Endocrinology; Proteinuria

OBJECTIVE: Albuminuria in type 2 diabetic patients is a risk factor for cardiovascular disease. We investigated the correlation between albuminuria and spontaneous microaggregation of platelets (SMAP) formed under shear stress. RESEARCH DESIGN AND METHODS: The study subjects were 401 type 2 diabetic...