Dicer, Drosha, and Outcomes in Patients with Ovarian Cancer

• Published in: The New England journal of medicine Vol. 359; no. 25; pp. 2641 - 2650
• Main Authors: Merritt, William M, Lin, Yvonne G, Han, Liz Y, Kamat, Aparna A, Spannuth, Whitney A, Schmandt, Rosemarie, Urbauer, Diana, Pennacchio, Len A, Cheng, Jan-Fang, Nick, Alpa M, Deavers, Michael T, Mourad-Zeidan, Alexandra, Wang, Hua, Mueller, Peter, Lenburg, Marc E, Gray, Joe W, Mok, Samuel, Birrer, Michael J, Lopez-Berestein, Gabriel, Coleman, Robert L, Bar-Eli, Menashe, Sood, Anil K
• Format: Journal Article
• Language: English
• Published: Waltham, MA Massachusetts Medical Society 18.12.2008
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Cell Line, Tumor; DEAD-box RNA Helicases - genetics; DEAD-box RNA Helicases - metabolism; DNA Mutational Analysis; Endoribonucleases - genetics; Endoribonucleases - metabolism; Female; Female genital diseases; Gene Expression Regulation, Neoplastic; General aspects; Gynecology. Andrology. Obstetrics; Humans; Kaplan-Meier Estimate; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Medical sciences; MicroRNAs - metabolism; Middle Aged; Multivariate Analysis; Mutation, Missense; Neoplasm Staging; Neoplasms, Glandular and Epithelial - genetics; Neoplasms, Glandular and Epithelial - metabolism; Neoplasms, Glandular and Epithelial - mortality; Ovarian cancer; Ovarian Neoplasms - genetics; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - mortality; Prognosis; Proteins; Reverse Transcriptase Polymerase Chain Reaction; Ribonuclease III - genetics; Ribonuclease III - metabolism; RNA Interference; RNA, Messenger - metabolism; RNA, Small Interfering; Transfection; Treatment Outcome; Tumors; Human; Medicine; Ovarian diseases; Gene silencing; RNA interference; Prognosis; Ovary cancer; Evolution; Patient; Malignant tumor; Cancer; Female genital diseases

Dicer and Drosha are RNase enzymes involved in RNA interference from precursor molecules. RNA interference can either silence or enhance the expression of specific target genes. This study of ovarian-cancer cells showed that the combination of low Dicer expression and low Drosha expression was assoc...