Biomimetic emulsions reveal the effect of mechanical forces on cell–cell adhesion

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 109; no. 25; pp. 9839 - 9844
• Main Authors: Pontani, Lea-Laetitia, Jorjadze, Ivane, Viasnoff, Virgile, Brujic, Jasna
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 19.06.2012; National Acad Sciences
• Subjects: Adhesion; Adhesives; Biological Sciences; Biomimetics; Cell Adhesion; Cell adhesion & migration; Cytoskeleton; droplets; electrostatic interactions; Electrostatics; Emulsions; Interfacial tension; Lipids; mechanics; Microstructure; Modeling; Phase diagrams; Physical Sciences; Pressure; salt concentration; surface interactions; Three dimensional imaging; tissues

Cell–cell contacts in tissues are continuously subject to mechanical forces due to homeostatic pressure and active cytoskeleton dynamics. In the process of cellular adhesion, the molecular pathways are well characterized but the role of mechanics is less well understood. To isolate the role of press...