Neck observation is appropriate in T1–2, cN0 oral squamous cell carcinoma without perineural invasion or lymphovascular invasion

• Published in: Oral oncology Vol. 50; no. 9; pp. 857 - 862
• Main Authors: Yeh, Chien-Fu, Li, Wing-Yin, Yang, Muh-Hwa, Chu, Pen-Yuan, Lu, Yen-Ting, Wang, Yi-Fen, Chang, Peter Mu-Hsin, Tai, Shyh-Kuan
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.09.2014; Elsevier
• Subjects: Biological and medical sciences; Carcinoma, Squamous Cell - pathology; Hematology, Oncology and Palliative Medicine; Humans; Lymphatic Metastasis; Lymphovascular invasion; Medical sciences; Mouth Neoplasms - pathology; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Neck - pathology; Neck dissection; Neoplasm Invasiveness; Observation; Oral squamous cell carcinoma; Otolaryngology; Otorhinolaryngology. Stomatology; Perineural invasion; Tumors; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; Observation; Oral squamous cell carcinoma; Perineural invasion; Neck dissection; Lymphovascular invasion; Stomatology; ENT; Malignant tumor; Perineurium; Cancerology; Treatment; Surgery; Oral cavity disease; Neck; Dissection; Cancer

Management of cN0 neck, elective neck dissection (END) or observation, remains controversial for T1–2 oral squamous cell carcinoma (OSCC). To allow for the safe observation of cN0 neck, it is mandatory to define predictors with high negative predictive value (NPV) for cervical lymph node (LN) status...