Parallel bacterial evolution within multiple patients identifies candidate pathogenicity genes

• Published in: Nature genetics Vol. 43; no. 12; pp. 1275 - 1280
• Main Authors: Lieberman, Tami D, Michel, Jean-Baptiste, Aingaran, Mythili, Potter-Bynoe, Gail, Roux, Damien, Davis, Michael R, Skurnik, David, Leiby, Nicholas, LiPuma, John J, Goldberg, Joanna B, McAdam, Alexander J, Priebe, Gregory P, Kishony, Roy
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.12.2011; Nature Publishing Group
• Subjects: 631/208/2489/144; 631/208/514/1948; 631/326/41/2531; Adaptation, Biological; Agriculture; Animal Genetics and Genomics; Anti-Bacterial Agents - pharmacology; Antibiotic resistance; Antibiotics; Bacteremia - microbiology; Bacteria; Bacterial genetics; Bacterial infections; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Burkholderia; Burkholderia - drug effects; Burkholderia - genetics; Burkholderia - pathogenicity; Burkholderia Infections - epidemiology; Burkholderia Infections - microbiology; Cancer Research; Ciprofloxacin - pharmacology; Cloning; Cystic fibrosis; Drug Resistance, Bacterial; Epidemics; Evolution; Evolution & development; Evolution, Molecular; Evolutionary biology; Fundamental and applied biological sciences. Psychology; Gene Function; Genes, Bacterial; Genetic aspects; Genetic diversity; Genetics of eukaryotes. Biological and molecular evolution; Genome, Bacterial; Genomes; Hospitals; Host-Pathogen Interactions; Human Genetics; Human subjects; Humans; letter; Likelihood Functions; Lipopolysaccharides - genetics; Lung Diseases - microbiology; Microbial mutation; Mutation; Pathogenesis; Pathogens; Phylogeny; Polymorphism, Single Nucleotide; Retrospective Studies; Selection, Genetic; Virulence Factors - genetics; United States; Infection; Human; Pathogenicity; Molecular evolution; Bacteriosis; Bacteria; Candidate gene; Identification

Roy Kishony and colleagues sequenced the genomes of 112 Burkholderia dolosa isolates recovered from 14 individuals with cystic fibrosis as part of a retrospective study from a hospital epidemic monitored over the course of 16 years. They tracked recurrent mutations occurring in the bacterial isolate...