GABARAPs regulate PI4P-dependent autophagosome:lysosome fusion

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 112; no. 22; pp. 7015 - 7020
• Main Authors: Wang, Hanzhi, Sun, Hui-Qiao, Zhu, Xiaohui, Zhang, Li, Albanesi, Joseph, Levine, Beth, Yin, Helen
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 02.06.2015; National Acad Sciences
• Subjects: 1-phosphatidylinositol 4-kinase; Adaptor Proteins, Signal Transducing - metabolism; autophagy; Biological Sciences; Biosynthesis; Cell Fusion; Cells; Fusion; gamma-aminobutyric acid; Gene expression; HeLa Cells; Humans; Immunoprecipitation; lipids; lysosomes; Lysosomes - metabolism; mammals; Maturation; Membranes; Microscopy, Confocal; Microscopy, Electron; Microtubule-Associated Proteins - metabolism; Minor Histocompatibility Antigens; Phagosomes - metabolism; Phosphatidylinositol Phosphates - metabolism; Phosphotransferases (Alcohol Group Acceptor) - metabolism; Proteins; RNA, Small Interfering - genetics; PI4P; autophagy; autophagosome:lysosome fusion; PI4KIIα; GABARAP

Significance Autophagy is an essential homeostatic process that is critically important for maintaining health and that is dysregulated in multiple devastating diseases. The steps in the final stages of autophagy that culminate in autophagosome:lysosome fusion are not well understood. The γ-aminobut...