Gut microbes in cardiovascular diseases and their potential therapeutic applications

Microbial ecosystem comprises a complex community in which bacteria interact with each other. The potential roles of the intestinal microbiome play in human health have gained considerable attention. The imbalance of gut microbial community has been looked to multiple chronic diseases. Cardiovascula...

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Published inProtein & cell Vol. 12; no. 5; pp. 346 - 359
Main Authors Jin, Ling, Shi, Xiaoming, Yang, Jing, Zhao, Yangyu, Xue, Lixiang, Xu, Li, Cai, Jun
Format Journal Article
LanguageEnglish
Published Beijing Higher Education Press 01.05.2021
Springer Nature B.V
Oxford University Press
Subjects
action mechanism
Biochemistry
Biomedical and Life Sciences
Cardiovascular diseases
Cardiovascular Diseases - microbiology
Cardiovascular Diseases - mortality
Cell Biology
Developmental Biology
Digestive system
Environmental factors
Gastrointestinal Microbiome
Gastrointestinal tract
gut microbiota
Human Genetics
Humans
Intestinal microflora
Intestine
Life Sciences
Microbiomes
Microorganisms
Morbidity
Protein Science
Review
Stem Cells
Therapeutic applications
cardiovascular diseases
action mechanism
gut microbiota
therapeutic applications
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Abstract Microbial ecosystem comprises a complex community in which bacteria interact with each other. The potential roles of the intestinal microbiome play in human health have gained considerable attention. The imbalance of gut microbial community has been looked to multiple chronic diseases. Cardiovascular diseases (CVDs) are leading causes of morbidity worldwide and are influenced by genetic and environmental factors. Recent advances have provided scientific evidence that CVD may also be attributed to gut microbiome. In this review, we highlight the complex interplay between microbes, their metabolites, and the potential influence on the generation and development of CVDs. The therapeutic potential of using intestinal microbiomes to treat CVD is also discussed. It is quite possible that gut microbes may be used for clinical treatments of CVD in the near future.
AbstractList Microbial ecosystem comprises a complex community in which bacteria interact with each other. The potential roles of the intestinal microbiome play in human health have gained considerable attention. The imbalance of gut microbial community has been looked to multiple chronic diseases. Cardiovascular diseases (CVDs) are leading causes of morbidity worldwide and are influenced by genetic and environmental factors. Recent advances have provided scientific evidence that CVD may also be attributed to gut microbiome. In this review, we highlight the complex interplay between microbes, their metabolites, and the potential influence on the generation and development of CVDs. The therapeutic potential of using intestinal microbiomes to treat CVD is also discussed. It is quite possible that gut microbes may be used for clinical treatments of CVD in the near future.
Microbial ecosystem comprises a complex community in which bacteria interact with each other. The potential roles of the intestinal microbiome play in human health have gained considerable attention. The imbalance of gut microbial community has been looked to multiple chronic diseases. Cardiovascular diseases (CVDs) are leading causes of morbidity worldwide and are influenced by genetic and environmental factors. Recent advances have provided scientific evidence that CVD may also be attributed to gut microbiome. In this review, we highlight the complex interplay between microbes, their metabolites, and the potential influence on the generation and development of CVDs. The therapeutic potential of using intestinal microbiomes to treat CVD is also discussed. It is quite possible that gut microbes may be used for clinical treatments of CVD in the near future.Microbial ecosystem comprises a complex community in which bacteria interact with each other. The potential roles of the intestinal microbiome play in human health have gained considerable attention. The imbalance of gut microbial community has been looked to multiple chronic diseases. Cardiovascular diseases (CVDs) are leading causes of morbidity worldwide and are influenced by genetic and environmental factors. Recent advances have provided scientific evidence that CVD may also be attributed to gut microbiome. In this review, we highlight the complex interplay between microbes, their metabolites, and the potential influence on the generation and development of CVDs. The therapeutic potential of using intestinal microbiomes to treat CVD is also discussed. It is quite possible that gut microbes may be used for clinical treatments of CVD in the near future.
Abstract Microbial ecosystem comprises a complex community in which bacteria interact with each other. The potential roles of the intestinal microbiome play in human health have gained considerable attention. The imbalance of gut microbial community has been looked to multiple chronic diseases. Cardiovascular diseases (CVDs) are leading causes of morbidity worldwide and are influenced by genetic and environmental factors. Recent advances have provided scientific evidence that CVD may also be attributed to gut microbiome. In this review, we highlight the complex interplay between microbes, their metabolites, and the potential influence on the generation and development of CVDs. The therapeutic potential of using intestinal microbiomes to treat CVD is also discussed. It is quite possible that gut microbes may be used for clinical treatments of CVD in the near future.
Author Shi, Xiaoming
Xu, Li
Jin, Ling
Cai, Jun
Yang, Jing
Xue, Lixiang
Zhao, Yangyu
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  organization: Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, China
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  givenname: Jun
  surname: Cai
  fullname: Cai, Jun
  email: caijun@fuwaihospital.org (J. Cai)
  organization: Hypertension center of Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32989686$$D View this record in MEDLINE/PubMed
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Issue 5
Keywords cardiovascular diseases
action mechanism
gut microbiota
therapeutic applications
Language English
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Notes Document accepted on :2020-08-19
cardiovascular diseases
action mechanism
gut microbiota
Document received on :2020-05-05
therapeutic applications
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SourceType-Scholarly Journals-1
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content type line 14
ObjectType-Review-3
content type line 23
OpenAccessLink https://doi.org/10.1007/s13238-020-00785-9
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  day: 01
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PublicationTitle Protein & cell
PublicationTitleAbbrev Protein Cell
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PublicationYear 2021
Publisher Higher Education Press
Springer Nature B.V
Oxford University Press
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Snippet Microbial ecosystem comprises a complex community in which bacteria interact with each other. The potential roles of the intestinal microbiome play in human...
Abstract Microbial ecosystem comprises a complex community in which bacteria interact with each other. The potential roles of the intestinal microbiome play in...
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StartPage 346
SubjectTerms action mechanism
Biochemistry
Biomedical and Life Sciences
Cardiovascular diseases
Cardiovascular Diseases - microbiology
Cardiovascular Diseases - mortality
Cell Biology
Developmental Biology
Digestive system
Environmental factors
Gastrointestinal Microbiome
Gastrointestinal tract
gut microbiota
Human Genetics
Humans
Intestinal microflora
Intestine
Life Sciences
Microbiomes
Microorganisms
Morbidity
Protein Science
Review
Stem Cells
Therapeutic applications
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Title Gut microbes in cardiovascular diseases and their potential therapeutic applications
URI https://journal.hep.com.cn/pac/EN/10.1007/s13238-020-00785-9
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Volume 12
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