Relaxin Regulation of Endometrial Structure and Function in the Rhesus Monkey

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 101; no. 13; pp. 4685 - 4689
• Main Authors: Goldsmith, Laura T., Weiss, Gerson, Palejwala, Smita, Plant, Tony M., Wojtczuk, Andrea, Lambert, W. Clark, Ammur, Nael, Heller, Debra, Skurnick, Joan H., Edwards, Dean, Cole, Donna M., Lieberman, Seymour
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 30.03.2004; National Acad Sciences
• Subjects: Anatomy & physiology; Animals; Biological Sciences; Body Weight; Connective tissues; Endocrinology; Endometrium; Endometrium - anatomy & histology; Endometrium - blood supply; Endometrium - physiology; Epithelial cells; Estradiol - pharmacology; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogen receptors; Female; Hormones; Humans; Lymphocytes; Macaca mulatta; Mammals; Monkeys & apes; Neovascularization, Physiologic - drug effects; Organ Size - drug effects; Ovariectomy; Pregnancy; Primates; Progesterone - pharmacology; Progesterone receptors; Proteins; Receptors, Estrogen - antagonists & inhibitors; Receptors, Estrogen - drug effects; Receptors, Estrogen - physiology; Relaxin - physiology; Reproduction; Uterus - anatomy & histology; Uterus - drug effects

Despite the documented importance of the protein hormone relaxin in reproduction in various mammalian species, the role of relaxin in human reproduction is poorly understood, largely because of the lack of studies in women or in suitable non-human primate models. Here we describe the establishment o...