Systemic Effects of Inflammation on Health during Chronic HIV Infection

• Published in: Immunity (Cambridge, Mass.) Vol. 39; no. 4; pp. 633 - 645
• Main Authors: Deeks, Steven G., Tracy, Russell, Douek, Daniel C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 17.10.2013; Elsevier Limited
• Subjects: Acquired immune deficiency syndrome; Age Factors; AIDS; Anti-HIV Agents - therapeutic use; Anti-Inflammatory Agents - therapeutic use; Antiretroviral drugs; Chronic Disease; Drug therapy; HIV; HIV - immunology; HIV Infections - complications; HIV Infections - drug therapy; HIV Infections - immunology; HIV Infections - physiopathology; Human immunodeficiency virus; Humans; Immunity, Innate; Inflammation - etiology; Inflammation - immunology; Inflammation - physiopathology; Intestinal Mucosa - immunology; Intestinal Mucosa - physiopathology; Liver - immunology; Liver - physiopathology; Models, Immunological; Monocytes - immunology; Monocytes - pathology; Mortality; Multiple Organ Failure - etiology; Multiple Organ Failure - immunology; Multiple Organ Failure - physiopathology; Protein Biosynthesis - immunology; Thrombophilia - drug therapy; Thrombophilia - etiology; Thrombophilia - immunology; Thrombophilia - physiopathology

Combination antiretroviral therapy for HIV infection improves immune function and eliminates the risk of AIDS-related complications but does not restore full health. HIV-infected adults have excess risk of cardiovascular, liver, kidney, bone, and neurologic diseases. Many markers of inflammation are...