Regulation of amino-acid metabolism controls flux to lipid accumulation in Yarrowia lipolytica

• Published in: NPJ systems biology and applications Vol. 2; no. 1; p. 16005
• Main Authors: Kerkhoven, Eduard J, Pomraning, Kyle R, Baker, Scott E, Nielsen, Jens
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2016; Nature Publishing Group; Springer Nature
• Subjects: 631/326; 631/553/1833; 631/553/318; 631/61; BASIC BIOLOGICAL SCIENCES; Bioinformatics; biotechnology; chemostat; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Life Sciences; lipid; metabolic engineering; microbiology; systems analysis; Systems Biology; Yarrowia lipolytica

Yarrowia lipolytica is a promising microbial cell factory for the production of lipids to be used as fuels and chemicals, but there are few studies on regulation of its metabolism. Here we performed the first integrated data analysis of Y. lipolytica grown in carbon and nitrogen limited chemostat cu...