NetCTLpan: pan-specific MHC class I pathway epitope predictions

• Published in: Immunogenetics (New York) Vol. 62; no. 6; pp. 357 - 368
• Main Authors: Stranzl, Thomas, Larsen, Mette Voldby, Lundegaard, Claus, Nielsen, Morten
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.06.2010; Springer-Verlag; Springer Nature B.V
• Subjects: Allergology; Antigen presentation; ATP-Binding Cassette Transporters - metabolism; Biomedical and Life Sciences; Biomedicine; Cell Biology; CTL epitope; Cytotoxicity; Epitopes, T-Lymphocyte; Gene Function; Histocompatibility Antigens Class I - immunology; HLA; Human Genetics; Humans; Immunology; Leukocytes; Ligands; Lymphocytes; Methods; MHC class I pathway; MHC polymorphism; Original Paper; Pan-specific prediction; Peptides; Proteasome Endopeptidase Complex - physiology; Protein Transport; Proteins; T-Lymphocytes, Cytotoxic - immunology; MHC polymorphism; Pan-specific prediction; HLA; CTL epitope; MHC class I pathway

Reliable predictions of immunogenic peptides are essential in rational vaccine design and can minimize the experimental effort needed to identify epitopes. In this work, we describe a pan-specific major histocompatibility complex (MHC) class I epitope predictor, NetCTLpan. The method integrates pred...