Plasticity of Leukocytic Exudates in Resolving Acute Inflammation Is Regulated by MicroRNA and Proresolving Mediators

• Published in: Immunity (Cambridge, Mass.) Vol. 39; no. 5; pp. 885 - 898
• Main Authors: Li, Yongsheng, Dalli, Jesmond, Chiang, Nan, Baron, Rebecca M., Quintana, Carolina, Serhan, Charles N.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.11.2013; Elsevier Limited
• Subjects: Acute Disease; Animals; Apoptosis; Biosynthesis; Chemotaxis - physiology; Docosahexaenoic Acids - metabolism; Gene expression; Gene Expression Regulation; Human subjects; Humans; Inflammation Mediators - metabolism; Leukocytes; Macrophages - metabolism; Male; Mice; MicroRNAs - biosynthesis; MicroRNAs - genetics; MicroRNAs - physiology; Neutrophils - metabolism; NF-kappa B - metabolism; Peritonitis - chemically induced; Peritonitis - immunology; Peritonitis - metabolism; Peritonitis - pathology; Phagocytosis - physiology; Sepsis; Sepsis - blood; Sepsis - mortality; Transcription Factor AP-1 - metabolism; Transcription, Genetic; Zymosan - toxicity

The magnitude and duration of acute inflammation are controlled by active resolution programs involving specialized proresolving mediators (SPMs; resolvins and maresins) and microRNAs (miRNAs). Here, we report that miR-466l was temporally regulated in murine exudate-infiltrating leukocytes. Neutroph...