Lipid-dependent regulation of the unfolded protein response

• Published in: Current opinion in cell biology Vol. 33; pp. 67 - 73
• Main Authors: Volmer, Romain, Ron, David
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2015; Elsevier
• Subjects: Animals; Endoplasmic Reticulum - metabolism; Eukaryota - metabolism; Humans; Internal Medicine; Life Sciences; Lipid Metabolism; Molecular Chaperones - biosynthesis; Molecular Chaperones - genetics; Molecular Chaperones - metabolism; Protein Folding; Signal Transduction; Unfolded Protein Response

Protein folding homeostasis in the lumen of the endoplasmic reticulum is defended by signal transduction pathways that are activated by an imbalance between unfolded proteins and chaperones (so called ER stress). Collectively referred to as the unfolded protein response (UPR) this homeostatic respon...