Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection

• Published in: Immunity (Cambridge, Mass.) Vol. 45; no. 4; pp. 861 - 876
• Main Authors: Cronan, Mark R., Beerman, Rebecca W., Rosenberg, Allison F., Saelens, Joseph W., Johnson, Matthew G., Oehlers, Stefan H., Sisk, Dana M., Jurcic Smith, Kristen L., Medvitz, Neil A., Miller, Sara E., Trinh, Le A., Fraser, Scott E., Madden, John F., Turner, Joanne, Stout, Jason E., Lee, Sunhee, Tobin, David M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 18.10.2016; Elsevier Limited
• Subjects: Animals; Cadherins - immunology; Epithelium - immunology; Epithelium - microbiology; Experiments; Granuloma - immunology; Granuloma - microbiology; Histology; Immunoglobulins; Infections; Keratin; Laboratories; Macrophages - immunology; Macrophages - microbiology; Microscopy; Mycobacterium marinum - immunology; Mycobacterium tuberculosis; Mycobacterium tuberculosis - immunology; Pathology; Tuberculosis; Zebrafish

Mycobacterium tuberculosis infection in humans triggers formation of granulomas, which are tightly organized immune cell aggregates that are the central structure of tuberculosis. Infected and uninfected macrophages interdigitate, assuming an altered, flattened appearance. Although pathologists have...