Differential Lipid Accumulation on HepG2 Cells Triggered by Palmitic and Linoleic Fatty Acids Exposure

• Published in: Molecules (Basel, Switzerland) Vol. 28; no. 5; p. 2367
• Main Authors: Teixeira, Francisca S., Pimentel, Lígia L., Vidigal, Susana S. M. P., Azevedo-Silva, João, Pintado, Manuela E., Rodríguez-Alcalá, Luís M.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 04.03.2023; MDPI
• Subjects: Apoptosis; Cholesterol - metabolism; Fatty acids; Fatty Acids - metabolism; Hep G2 Cells; Hepatocytes; Humans; Linoleic Acid - pharmacology; Linoleic Acids - metabolism; lipid accumulation; Lipid Metabolism; Lipids; Liver; Metabolism; Oil Red O; Oxidation; Oxidative stress; Palmitic Acid - pharmacology; Physiological aspects; Polyunsaturated fatty acids; Ratios; Reactive oxygen species; Reactive Oxygen Species - metabolism; Saturated fatty acids; steatosis; Triglycerides; Triglycerides - metabolism; Unsaturated fatty acids; United States; Massachusetts; Germany; Pennsylvania; Oil Red O; triglycerides; fatty acids; lipid accumulation; steatosis; hepatocytes

Lipid metabolism pathways such as β-oxidation, lipolysis and, lipogenesis, are mainly associated with normal liver function. However, steatosis is a growing pathology caused by the accumulation of lipids in hepatic cells due to increased lipogenesis, dysregulated lipid metabolism, and/or reduced lip...