PPAR-alpha dependent regulation of vanin-1 mediates hepatic lipid metabolism - van Diepen, Janna A.; Jansen, Patrick A.; Ballak, Dov B.; Hijmans, Anneke; Hooiveld, Guido J.; Rommelaere, Samuel; Galland, Franck; Naquet, Philippe; Rutjes, Floris P.J.T.; Mensink, Ronald P.; Schrauwen, Patrick; Tack, Cees J.; et al. (Journal of hepatology, 2014)
Keywords: acids; Amidohydrolases - physiology; Animals; cysteamine; Fasting; Fatty Liver - etiology; Fenofibrate; Gastroenterology and Hepatology; gene-expression; GPI-Linked Proteins - physiology; hepatocytes; high-fat diet; Humans; insulin-resistance; Lipid; Lipid Metabolism; liver; Liver - metabolism; Male; Mice; Mice, Inbred C57BL; null mice; Pantetheinase; Peroxisome proliferator-activated receptor alpha α; PPAR; PPAR alpha - physiology; Rats; Rats, Wistar; Starvation - metabolism; Steatosis; tissue; Triglyceride; Vanin; FFA; Vanin; NAFLD; CBFB; RXR; Pan-PNa; Abcd2; PPAR; Pan-AMC; WT; BMI; XBP1; Fasting; STAT3; Acot1; Ehhadh; Acot2; Acadm; NASH; Triglyceride; KLF15; Lipid; TC; Steatosis; Fenofibrate; Peroxisome proliferator-activated receptor alpha α; VNN1; TG; VNN2; VNN3; SP1; Acsl5; Pantetheinase; non-alcoholic steatohepatitis (NASH); total cholesterol; x-box binding protein 1; Peroxisome proliferator-activated receptor; enoyl-CoA hydratase/3-hydroxylacyl CoA dehydrogenase; body mass index; Retinoid X Receptor; Kruppel-like factor 15; core binding factor beta; non-alcoholic fatty liver disease; chemokine (C-C motif) ligand 17; vanin-1; vanin-2; vanin-3; free fatty acids; acyl-CoA thioesterase 1; acyl-CoA synthetase long-chain family member 5; acyl-CoA thioesterase 2; trans-acting transcription factor 1; pantothenate-7-amino-4-methylcoumarin; Triglycerides; signal transducer and activator of transcription 3; acyl-CoA dehydrogenase, medium chain; pantothenate-4-nitroanilide; wild-type