The pathogenesis of Plasmodium falciparum malaria in humans: insights from splenic physiology

• Published in: Blood Vol. 117; no. 2; pp. 381 - 392
• Main Authors: Buffet, Pierre A., Safeukui, Innocent, Deplaine, Guillaume, Brousse, Valentine, Prendki, Virginie, Thellier, Marc, Turner, Gareth D., Mercereau-Puijalon, Odile
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 13.01.2011; Americain Society of Hematology; American Society of Hematology
• Series: Review Article
• Subjects: Biological and medical sciences; Erythrocytes - parasitology; Hematologic and hematopoietic diseases; Human protozoal diseases; Humans; Infectious diseases; Malaria; Malaria, Falciparum - physiopathology; Medical sciences; Parasitic diseases; Plasmodium falciparum; Plasmodium falciparum - physiology; Protozoal diseases; Review; Spleen - parasitology; Spleen - physiopathology; Infection; Human; Spleen; Protozoa; Plasmodium falciparum; Apicomplexa; Protozoal disease; Hematology; Malaria; Pathogenesis; Physiology; Parasitosis

Clinical manifestations of Plasmodium falciparum infection are induced by the asexual stages of the parasite that develop inside red blood cells (RBCs). Because splenic microcirculatory beds filter out altered RBCs, the spleen can innately clear subpopulations of infected or uninfected RBC modified...