Selective vulnerability of tripartite synapses in amyotrophic lateral sclerosis

• Published in: Acta neuropathologica Vol. 143; no. 4; pp. 471 - 486
• Main Authors: Broadhead, Matthew J., Bonthron, Calum, Waddington, Julia, Smith, William V., Lopez, Maite F., Burley, Sarah, Valli, Jessica, Zhu, Fei, Komiyama, Noboru H., Smith, Colin, Grant, Seth G. N., Miles, Gareth B.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2022; Springer; Springer Nature B.V
• Subjects: Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - pathology; Animal models; Animals; Astrocytes; Autopsy; Disease Models, Animal; Medicine; Medicine & Public Health; Mice; Mice, Transgenic; Microscopy; Motor Neurons - pathology; Nervous system diseases; Neurodegenerative diseases; Neurosciences; Original Paper; Pathology; Spinal cord; Spinal Cord - pathology; Superoxide Dismutase; Superoxide Dismutase-1 - genetics; Synapses; Synapses - pathology; ALS/MND; Synapse; Astrocyte; Neurodegeneration

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder. Separate lines of evidence suggest that synapses and astrocytes play a role in the pathological mechanisms underlying ALS. Given that astrocytes make specialised contacts with some synapses, called tripartite synapses, we hyp...