Endogenized viral sequences in mammals

• Published in: Current opinion in microbiology Vol. 31; pp. 176 - 183
• Main Authors: Parrish, Nicholas F., Tomonaga, Keizo
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2016
• Subjects: Adaptive Immunity - genetics; Animals; Endogenous Retroviruses - genetics; genome; Genome - genetics; germ cells; Humans; Immunity, Innate - genetics; Mammals - genetics; Mammals - virology; nucleotide sequences; Pathology; Retroviridae; RNA; transcription (genetics)

•Endogenous retroviruses (ERVs) make up 25% of the genome of mammals yet sequenced.•Different ERVs are involved in placenta formation in different mammalian lineages.•ERVs can mediate resistance to closely related exogenous viruses.•ERVs modulate the innate immune system and help maintain pluripoten...