Nuclear peripheral chromatin-lamin B1 interaction is required for global integrity of chromatin architecture and dynamics in human cells

• Published in: Protein & cell Vol. 13; no. 4; pp. 258 - 280
• Main Authors: Chang, Lei, Li, Mengfan, Shao, Shipeng, Li, Chen, Ai, Shanshan, Xue, Boxin, Hou, Yingping, Zhang, Yiwen, Li, Ruifeng, Fan, Xiaoying, He, Aibin, Li, Cheng, Sun, Yujie
• Format: Journal Article
• Language: English
• Published: Beijing Higher Education Press 01.04.2022; Springer Nature B.V
• Subjects: 3D genome; A/B compartments; Biochemistry; Biomedical and Life Sciences; Cell Biology; Chromatin; chromatin dynamics; chromosome territories; Chromosomes; Conformation; Developmental Biology; Genome; Genomes; Genomics; Hi-C; Human Genetics; Humans; lamin B1; Lamin Type B - genetics; Life Sciences; livecell imaging; Protein Science; Research Article; Stem Cells; super-resolution imaging; A/B compartments; Hi-C; lamin B1; live-cell imaging; 3D genome; chromatin dynamics; super-resolution imaging; chromosome territories

The eukaryotic genome is folded into higher-order conformation accompanied with constrained dynamics for coordinated genome functions. However, the molecular machinery underlying these hierarchically organized three-dimensional (3D) chromatin architecture and dynamics remains poorly understood. Here...