Distinctive disruption patterns of white matter tracts in Alzheimer's disease with full diffusion tensor characterization

• Published in: Neurobiology of aging Vol. 33; no. 9; pp. 2029 - 2045
• Main Authors: Huang, Hao, Fan, Xin, Weiner, Myron, Martin-Cook, Kristin, Xiao, Guanghua, Davis, Jeannie, Devous, Michael, Rosenberg, Roger, Diaz-Arrastia, Ramon
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2012
• Subjects: Aged; Aging; Alzheimer Disease - pathology; Alzheimer's disease; Anisotropy; Biomarker; Brain - pathology; Brain Mapping; Case-Control Studies; Diffusion Magnetic Resonance Imaging; DTI; Female; Humans; Internal Medicine; Male; Mental Status Schedule; Middle Aged; Nerve Fibers, Myelinated - pathology; Neurology; Neuropsychological Tests; Statistics as Topic; Tract group; White matter tract; White matter tract; DTI; Atlas; Biomarker; Tract group; Alzheimer's disease

To characterize the white matter structural changes at the tract level and tract group level, comprehensive analysis with 4 metrics derived from diffusion tensor imaging (DTI), fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AxD) and radial diffusivity (RD), was conducted. Trac...