Distinctive disruption patterns of white matter tracts in Alzheimer's disease with full diffusion tensor characterization
To characterize the white matter structural changes at the tract level and tract group level, comprehensive analysis with 4 metrics derived from diffusion tensor imaging (DTI), fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AxD) and radial diffusivity (RD), was conducted. Trac...
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| Published in | Neurobiology of aging Vol. 33; no. 9; pp. 2029 - 2045 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.09.2012
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| Subjects | |
| Online Access | Get full text |
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| Abstract | To characterize the white matter structural changes at the tract level and tract group level, comprehensive analysis with 4 metrics derived from diffusion tensor imaging (DTI), fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AxD) and radial diffusivity (RD), was conducted. Tract groups, namely limbic, commissural, association, and projection tracts, include white matter tracts of similar functions. Diffusion tensor imaging data were acquired from 61 subjects (26 Alzheimer's disease [AD], 11 subjects with amnestic mild cognitive impairment [aMCI], and 24 age-matched controls). An atlas-based approach was used to survey 30 major cerebral white matter tracts with the measurements of FA, MD, AxD, and RD. Regional cortical atrophy and cognitive functions of AD patients were also measured to correlate with the structural changes of white matter. Synchronized structural changes of cingulum bundle and fornix, both of which are part of limbic tract group, were revealed. Widespread yet distinctive structural changes were found in limbic, commissural, association, and projection tract groups between control and AD subjects. Specifically, FA, MD, and RD of limbic tracts, FA, MD, AxD, and RD of commissural tracts, MD, AxD, and RD of association tracts, and MD and AxD of projection tracts are significantly different between AD patients and control subjects. In contrast, the comparison between aMCI and control subjects shows disruption only in the limbic and commissural tract groups of aMCI subjects. MD values of all tract groups of AD patients are significantly correlated to cognitive functions. Difference between AD and control and that between aMCI and control indicates a progression pattern of white matter disruption from limbic and commissural tract group to other tract groups. High correlation between FA, MD, and RD measurements from limbic tracts and cortical atrophy suggests the disruption of the limbic tract group is caused by the neuronal damage. |
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| AbstractList | To characterize the white matter structural changes at the tract level and tract group level, comprehensive analysis with four metrics derived from DTI, fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AxD) and radial diffusivity (RD), was conducted. Tract groups, namely limbic, commissural, association and projection tracts, include white matter tracts of similar functions. DTI data were acquired from 61 subjects (26 AD, 11 subjects with amnestic mild cognitive impairment or aMCI, 24 age-matched controls). An atlas-based approach was used to survey 30 major cerebral white matter tracts with the measurements of FA, MD, AxD and RD. Regional cortical atrophy and cognitive functions of AD patients were also measured to correlate with the structural changes of white matter. Synchronized structural changes of cingulum bundle and fornix, both of which are part of limbic tract group, were revealed. Widespread yet distinctive structural changes were found in limbic, commissural, association and projection tract groups between control and AD subjects. Specifically, FA, MD and RD of limbic tracts, FA, MD, AxD and RD of commissural tracts, MD, AxD and RD of association tracts and MD and AxD of projection tracts are significantly different between AD patients and control subjects. In contrast, the comparison between aMCI and control subjects shows disruption only in the limbic and commissural tract groups of aMCI subjects. MD values of all tract groups of AD patients are significantly correlated to cognitive functions. Difference between AD and control and that between MCI and control indicates a progression pattern of white matter disruption from limbic and commissural tract group to other tract groups. High correlation between FA, MD and RD measurements from limbic tracts and cortical atrophy suggests the disruption of the limbic tract group is caused by the neuronal damage. To characterize the white matter structural changes at the tract level and tract group level, comprehensive analysis with 4 metrics derived from diffusion tensor imaging (DTI), fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AxD) and radial diffusivity (RD), was conducted. Tract groups, namely limbic, commissural, association, and projection tracts, include white matter tracts of similar functions. Diffusion tensor imaging data were acquired from 61 subjects (26 Alzheimer's disease [AD], 11 subjects with amnestic mild cognitive impairment [aMCI], and 24 age-matched controls). An atlas-based approach was used to survey 30 major cerebral white matter tracts with the measurements of FA, MD, AxD, and RD. Regional cortical atrophy and cognitive functions of AD patients were also measured to correlate with the structural changes of white matter. Synchronized structural changes of cingulum bundle and fornix, both of which are part of limbic tract group, were revealed. Widespread yet distinctive structural changes were found in limbic, commissural, association, and projection tract groups between control and AD subjects. Specifically, FA, MD, and RD of limbic tracts, FA, MD, AxD, and RD of commissural tracts, MD, AxD, and RD of association tracts, and MD and AxD of projection tracts are significantly different between AD patients and control subjects. In contrast, the comparison between aMCI and control subjects shows disruption only in the limbic and commissural tract groups of aMCI subjects. MD values of all tract groups of AD patients are significantly correlated to cognitive functions. Difference between AD and control and that between aMCI and control indicates a progression pattern of white matter disruption from limbic and commissural tract group to other tract groups. High correlation between FA, MD, and RD measurements from limbic tracts and cortical atrophy suggests the disruption of the limbic tract group is caused by the neuronal damage. To characterize the white matter structural changes at the tract level and tract group level, comprehensive analysis with 4 metrics derived from diffusion tensor imaging (DTI), fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AxD) and radial diffusivity (RD), was conducted. Tract groups, namely limbic, commissural, association, and projection tracts, include white matter tracts of similar functions. Diffusion tensor imaging data were acquired from 61 subjects (26 Alzheimer's disease [AD], 11 subjects with amnestic mild cognitive impairment [aMCI], and 24 age-matched controls). An atlas-based approach was used to survey 30 major cerebral white matter tracts with the measurements of FA, MD, AxD, and RD. Regional cortical atrophy and cognitive functions of AD patients were also measured to correlate with the structural changes of white matter. Synchronized structural changes of cingulum bundle and fornix, both of which are part of limbic tract group, were revealed. Widespread yet distinctive structural changes were found in limbic, commissural, association, and projection tract groups between control and AD subjects. Specifically, FA, MD, and RD of limbic tracts, FA, MD, AxD, and RD of commissural tracts, MD, AxD, and RD of association tracts, and MD and AxD of projection tracts are significantly different between AD patients and control subjects. In contrast, the comparison between aMCI and control subjects shows disruption only in the limbic and commissural tract groups of aMCI subjects. MD values of all tract groups of AD patients are significantly correlated to cognitive functions. Difference between AD and control and that between aMCI and control indicates a progression pattern of white matter disruption from limbic and commissural tract group to other tract groups. High correlation between FA, MD, and RD measurements from limbic tracts and cortical atrophy suggests the disruption of the limbic tract group is caused by the neuronal damage.To characterize the white matter structural changes at the tract level and tract group level, comprehensive analysis with 4 metrics derived from diffusion tensor imaging (DTI), fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AxD) and radial diffusivity (RD), was conducted. Tract groups, namely limbic, commissural, association, and projection tracts, include white matter tracts of similar functions. Diffusion tensor imaging data were acquired from 61 subjects (26 Alzheimer's disease [AD], 11 subjects with amnestic mild cognitive impairment [aMCI], and 24 age-matched controls). An atlas-based approach was used to survey 30 major cerebral white matter tracts with the measurements of FA, MD, AxD, and RD. Regional cortical atrophy and cognitive functions of AD patients were also measured to correlate with the structural changes of white matter. Synchronized structural changes of cingulum bundle and fornix, both of which are part of limbic tract group, were revealed. Widespread yet distinctive structural changes were found in limbic, commissural, association, and projection tract groups between control and AD subjects. Specifically, FA, MD, and RD of limbic tracts, FA, MD, AxD, and RD of commissural tracts, MD, AxD, and RD of association tracts, and MD and AxD of projection tracts are significantly different between AD patients and control subjects. In contrast, the comparison between aMCI and control subjects shows disruption only in the limbic and commissural tract groups of aMCI subjects. MD values of all tract groups of AD patients are significantly correlated to cognitive functions. Difference between AD and control and that between aMCI and control indicates a progression pattern of white matter disruption from limbic and commissural tract group to other tract groups. High correlation between FA, MD, and RD measurements from limbic tracts and cortical atrophy suggests the disruption of the limbic tract group is caused by the neuronal damage. Abstract To characterize the white matter structural changes at the tract level and tract group level, comprehensive analysis with 4 metrics derived from diffusion tensor imaging (DTI), fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AxD) and radial diffusivity (RD), was conducted. Tract groups, namely limbic, commissural, association, and projection tracts, include white matter tracts of similar functions. Diffusion tensor imaging data were acquired from 61 subjects (26 Alzheimer's disease [ AD ], 11 subjects with amnestic mild cognitive impairment [aMCI], and 24 age-matched controls). An atlas-based approach was used to survey 30 major cerebral white matter tracts with the measurements of FA, MD, AxD, and RD. Regional cortical atrophy and cognitive functions of AD patients were also measured to correlate with the structural changes of white matter. Synchronized structural changes of cingulum bundle and fornix, both of which are part of limbic tract group, were revealed. Widespread yet distinctive structural changes were found in limbic, commissural, association, and projection tract groups between control and AD subjects. Specifically, FA, MD, and RD of limbic tracts, FA, MD, AxD, and RD of commissural tracts, MD, AxD, and RD of association tracts, and MD and AxD of projection tracts are significantly different between AD patients and control subjects. In contrast, the comparison between aMCI and control subjects shows disruption only in the limbic and commissural tract groups of aMCI subjects. MD values of all tract groups of AD patients are significantly correlated to cognitive functions. Difference between AD and control and that between aMCI and control indicates a progression pattern of white matter disruption from limbic and commissural tract group to other tract groups. High correlation between FA, MD, and RD measurements from limbic tracts and cortical atrophy suggests the disruption of the limbic tract group is caused by the neuronal damage. |
| Author | Weiner, Myron Diaz-Arrastia, Ramon Huang, Hao Fan, Xin Martin-Cook, Kristin Xiao, Guanghua Devous, Michael Davis, Jeannie Rosenberg, Roger |
| AuthorAffiliation | 3 Department of Psychiatry, University of Texas Southwestern Medical Center 5 Alzheimer’s Disease Center, University of Texas Southwestern Medical Center 2 Department of Radiology, University of Texas Southwestern Medical Center 1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center 4 Department of Neurology, University of Texas Southwestern Medical Center 6 Department of Clinical Sciences, University of Texas Southwestern Medical Center |
| AuthorAffiliation_xml | – name: 2 Department of Radiology, University of Texas Southwestern Medical Center – name: 3 Department of Psychiatry, University of Texas Southwestern Medical Center – name: 1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center – name: 4 Department of Neurology, University of Texas Southwestern Medical Center – name: 6 Department of Clinical Sciences, University of Texas Southwestern Medical Center – name: 5 Alzheimer’s Disease Center, University of Texas Southwestern Medical Center |
| Author_xml | – sequence: 1 givenname: Hao surname: Huang fullname: Huang, Hao email: hao.huang@utsouthwestern.edu organization: Advanced Imaging Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA – sequence: 2 givenname: Xin surname: Fan fullname: Fan, Xin organization: Advanced Imaging Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA – sequence: 3 givenname: Myron surname: Weiner fullname: Weiner, Myron organization: Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA – sequence: 4 givenname: Kristin surname: Martin-Cook fullname: Martin-Cook, Kristin organization: Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA – sequence: 5 givenname: Guanghua surname: Xiao fullname: Xiao, Guanghua organization: Department of Clinical Sciences, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA – sequence: 6 givenname: Jeannie surname: Davis fullname: Davis, Jeannie organization: Advanced Imaging Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA – sequence: 7 givenname: Michael surname: Devous fullname: Devous, Michael organization: Department of Radiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA – sequence: 8 givenname: Roger surname: Rosenberg fullname: Rosenberg, Roger organization: Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA – sequence: 9 givenname: Ramon surname: Diaz-Arrastia fullname: Diaz-Arrastia, Ramon organization: Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21872362$$D View this record in MEDLINE/PubMed |
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| Keywords | White matter tract DTI Atlas Biomarker Tract group Alzheimer's disease |
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| Snippet | To characterize the white matter structural changes at the tract level and tract group level, comprehensive analysis with 4 metrics derived from diffusion... Abstract To characterize the white matter structural changes at the tract level and tract group level, comprehensive analysis with 4 metrics derived from... To characterize the white matter structural changes at the tract level and tract group level, comprehensive analysis with four metrics derived from DTI,... |
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| SubjectTerms | Aged Aging Alzheimer Disease - pathology Alzheimer's disease Anisotropy Biomarker Brain - pathology Brain Mapping Case-Control Studies Diffusion Magnetic Resonance Imaging DTI Female Humans Internal Medicine Male Mental Status Schedule Middle Aged Nerve Fibers, Myelinated - pathology Neurology Neuropsychological Tests Statistics as Topic Tract group White matter tract |
| Title | Distinctive disruption patterns of white matter tracts in Alzheimer's disease with full diffusion tensor characterization |
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