Mitophagy in carcinogenesis and cancer treatment

In order to maintain a functional mitochondrial network, cells have developed a quality control mechanism, namely mitophagy. This process can be induced through different pathways. The most studied is the so-called PINK1/Parkin pathway, which is associated with ubiquitylation of several mitochondria...

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Published inDiscover. Oncology Vol. 12; no. 1; p. 58
Main Authors Denisenko, Tatiana V., Gogvadze, Vladimir, Zhivotovsky, Boris
Format Journal Article
LanguageEnglish
Published New York Springer US 01.12.2021
Springer Nature B.V
Springer
Subjects
Apoptosis
Autophagy
Biosynthesis
Cancer
Cancer Research
Cancer therapies
Homeostasis
Hypoxia
Internal Medicine
Kinases
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Metabolism
Mitochondria
Mitophagy
Molecular Medicine
Mutation
Oncology
Oxidative stress
Parkinson's disease
Phosphorylation
Physiology
Proteins
Quality control
Radiotherapy
Review
Surgical Oncology
Tumorigenesis
Tumors
Homeostasis
Mitophagy
Autophagy
Cancer
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Summary:In order to maintain a functional mitochondrial network, cells have developed a quality control mechanism, namely mitophagy. This process can be induced through different pathways. The most studied is the so-called PINK1/Parkin pathway, which is associated with ubiquitylation of several mitochondrial proteins that were initially found to be related to Parkinson’s disease. Another type of mitophagy is known as receptor-mediated mitophagy, which includes proteins, such as BNIP3 and BNIP3L, also known as Nix. Through these two mechanisms, mitophagy fulfills its functions and maintains cellular homeostasis. Here, we summarize the current knowledge about the mechanisms of mitophagy regulation and their interplay with cancer progression as well as anticancer treatment.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:2730-6011
2730-6011
DOI:10.1007/s12672-021-00454-1