Calcium-Activated Chloride Channels (CaCCs) Regulate Action Potential and Synaptic Response in Hippocampal Neurons

• Published in: Neuron (Cambridge, Mass.) Vol. 74; no. 1; pp. 179 - 192
• Main Authors: Huang, Wendy C., Xiao, Shaohua, Huang, Fen, Harfe, Brian D., Jan, Yuh Nung, Jan, Lily Yeh
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.04.2012; Elsevier Limited
• Subjects: Action potential; Action Potentials - physiology; Animals; Anoctamin-1; Anoctamins; Calcium; Calcium - metabolism; Calcium channels; Calcium Channels - metabolism; Calcium influx; chloride channels (calcium-gated); Chloride Channels - physiology; Experiments; Feedback; Glutamic acid receptors (ionotropic); Hippocampus; Hippocampus - cytology; Hippocampus - metabolism; Ion channels; Learning; Memory; Mice; N-Methyl-D-aspartic acid receptors; Neurogenesis; Neuromodulation; Neurons; Neurotransmitter release; Pyramidal Cells - metabolism; Receptors, N-Methyl-D-Aspartate - metabolism; Synapses; Synaptic Potentials - physiology; Transmitters

Central neurons respond to synaptic inputs from other neurons by generating synaptic potentials. Once the summated synaptic potentials reach threshold for action potential firing, the signal propagates leading to transmitter release at the synapse. The calcium influx accompanying such signaling open...