Viruses as anticancer drugs

• Published in: Trends in pharmacological sciences (Regular ed.) Vol. 28; no. 7; pp. 326 - 333
• Main Authors: Russell, Stephen J., Peng, Kah-Whye
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2007
• Subjects: Advanced Basic Science; Antineoplastic Agents - adverse effects; Antineoplastic Agents - pharmacokinetics; Antineoplastic Agents - therapeutic use; Humans; Neoplasms - therapy; Oncolytic Virotherapy; Oncolytic Viruses - physiology

Oncolytic viruses are being developed as anticancer drugs. They propagate selectively in tumor tissue and destroy it without causing excessive damage to normal non-cancerous tissues. When used as drugs, they must meet stringent criteria for safety and efficacy and be amenable to pharmacological stud...