Molecular epidemiological study of enteroviruses associated with encephalitis in children from Hangzhou, China
Enterovirus (EV) has over 100 serotypes of species A-D, which can cause various symptoms in infants. Enterovirus encephalitis (EVE) is serve disease with high morbidity and mortality in children. To well define the epidemiology of EVE, we wanted to know more about EV and EV molecular typing by condu...
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| Published in | Medicine (Baltimore) Vol. 95; no. 40; p. e4870 |
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| Abstract | Enterovirus (EV) has over 100 serotypes of species A-D, which can cause various symptoms in infants. Enterovirus encephalitis (EVE) is serve disease with high morbidity and mortality in children. To well define the epidemiology of EVE, we wanted to know more about EV and EV molecular typing by conducting this study in Hangzhou.Cerebrospinal fluid samples were collected from children with diagnosis of encephalitis. Meanwhile, one-step real-time RT-PCR was used for the detection of EV, and we also identified the serotypes of EV by using gene sequencing of VP1 or 5'UTR region.A total of 126 CSF specimens were tested and EV was detected in 26 specimens (20.6%). The molecular typing results showed different types of EV strains including Coxsackievirus B2, Coxsackievirus B3, Echovirus 5, Echovirus 16, Echovirus 18, Echovirus 30, and all EV isolates belonging to the human EV species B.According to the sequence of VP1 and 5'UTR region, E30 may be major cause of children's EVE in Hangzhou, China. |
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| AbstractList | Enterovirus (EV) has over 100 serotypes of species A–D, which can cause various symptoms in infants. Enterovirus encephalitis (EVE) is serve disease with high morbidity and mortality in children. To well define the epidemiology of EVE, we wanted to know more about EV and EV molecular typing by conducting this study in Hangzhou.
Cerebrospinal fluid samples were collected from children with diagnosis of encephalitis. Meanwhile, one-step real-time RT-PCR was used for the detection of EV, and we also identified the serotypes of EV by using gene sequencing of VP1 or 5′UTR region.
A total of 126 CSF specimens were tested and EV was detected in 26 specimens (20.6%). The molecular typing results showed different types of EV strains including Coxsackievirus B2, Coxsackievirus B3, Echovirus 5, Echovirus 16, Echovirus 18, Echovirus 30, and all EV isolates belonging to the human EV species B.
According to the sequence of VP1 and 5′UTR region, E30 may be major cause of children's EVE in Hangzhou, China. Enterovirus (EV) has over 100 serotypes of species A-D, which can cause various symptoms in infants. Enterovirus encephalitis (EVE) is serve disease with high morbidity and mortality in children. To well define the epidemiology of EVE, we wanted to know more about EV and EV molecular typing by conducting this study in Hangzhou.Cerebrospinal fluid samples were collected from children with diagnosis of encephalitis. Meanwhile, one-step real-time RT-PCR was used for the detection of EV, and we also identified the serotypes of EV by using gene sequencing of VP1 or 5'UTR region.A total of 126 CSF specimens were tested and EV was detected in 26 specimens (20.6%). The molecular typing results showed different types of EV strains including Coxsackievirus B2, Coxsackievirus B3, Echovirus 5, Echovirus 16, Echovirus 18, Echovirus 30, and all EV isolates belonging to the human EV species B.According to the sequence of VP1 and 5'UTR region, E30 may be major cause of children's EVE in Hangzhou, China.Enterovirus (EV) has over 100 serotypes of species A-D, which can cause various symptoms in infants. Enterovirus encephalitis (EVE) is serve disease with high morbidity and mortality in children. To well define the epidemiology of EVE, we wanted to know more about EV and EV molecular typing by conducting this study in Hangzhou.Cerebrospinal fluid samples were collected from children with diagnosis of encephalitis. Meanwhile, one-step real-time RT-PCR was used for the detection of EV, and we also identified the serotypes of EV by using gene sequencing of VP1 or 5'UTR region.A total of 126 CSF specimens were tested and EV was detected in 26 specimens (20.6%). The molecular typing results showed different types of EV strains including Coxsackievirus B2, Coxsackievirus B3, Echovirus 5, Echovirus 16, Echovirus 18, Echovirus 30, and all EV isolates belonging to the human EV species B.According to the sequence of VP1 and 5'UTR region, E30 may be major cause of children's EVE in Hangzhou, China. Enterovirus (EV) has over 100 serotypes of species A-D, which can cause various symptoms in infants. Enterovirus encephalitis (EVE) is serve disease with high morbidity and mortality in children. To well define the epidemiology of EVE, we wanted to know more about EV and EV molecular typing by conducting this study in Hangzhou.Cerebrospinal fluid samples were collected from children with diagnosis of encephalitis. Meanwhile, one-step real-time RT-PCR was used for the detection of EV, and we also identified the serotypes of EV by using gene sequencing of VP1 or 5'UTR region.A total of 126 CSF specimens were tested and EV was detected in 26 specimens (20.6%). The molecular typing results showed different types of EV strains including Coxsackievirus B2, Coxsackievirus B3, Echovirus 5, Echovirus 16, Echovirus 18, Echovirus 30, and all EV isolates belonging to the human EV species B.According to the sequence of VP1 and 5'UTR region, E30 may be major cause of children's EVE in Hangzhou, China. |
| Author | Xiao-ting, Shen Shi-qiang, Shang Qiong, Zhang Yu-jie, Liu Qiang, Shu Li, Wei Jian-hua, Mao |
| AuthorAffiliation | Department of Clinical Laboratory, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, PR China |
| AuthorAffiliation_xml | – name: Department of Clinical Laboratory, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, PR China |
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| Cites_doi | 10.1016/j.jcv.2015.05.012 10.1128/JCM.01483-12 10.3201/eid1611.100672 10.1016/j.jcv.2011.02.011 10.1111/jpc.12656 10.1097/MD.0000000000000707 10.1007/s11262-011-0688-3 10.1002/jmv.23693 10.1186/s12985-015-0294-4 10.1086/592988 10.1128/JCM.00542-06 10.1016/j.diagmicrobio.2015.10.019 10.1016/j.jviromet.2015.06.009 10.1002/jmv.24267 10.1002/jmv.10412 10.1186/s12879-016-1690-0 10.1016/j.jinf.2013.09.020 10.1371/journal.pone.0144366 10.1371/journal.pone.0085023 10.1016/j.eimc.2012.07.007 10.1086/509330 10.1007/s00705-013-1709-4 10.1128/AEM.03200-14 |
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| References | Kong (R5-23-20210309) 2015; 222 Wu (R13-23-20210309) 2014; 50 Danthanarayana (R24-23-20210309) 2015; 87 Menasalvas-Ruiz (R9-23-20210309) 2013; 31 Kumar (R23-23-20210309) 2011; 51 Ma (R25-23-20210309) 2013; 158 Xie (R1-23-20210309) 2015; 10 Othman (R10-23-20210309) 2016; 84 Zhang (R6-23-20210309) 2013; 8 Lu (R16-23-20210309) 2015; 81 Kenneth (R3-23-20210309) 2009; 66 Cabrerizo (R22-23-20210309) 2008; 85 Zhou (R15-23-20210309) 2016; 16 Glaser (R19-23-20210309) 2006; 15 Li (R7-23-20210309) 2015; 12 Nix (R14-23-20210309) 2006; 44 Lewthwaite (R12-23-20210309) 2010; 16 Fowlkes (R2-23-20210309) 2008; 198 Österback (R26-23-20210309) 2015; 69 Zhao (R18-23-20210309) 2005; 26 Kyriakopoulou (R21-23-20210309) 2012; 44 Thoelen (R20-23-20210309) 2003; 70 Yang (R17-23-20210309) 2011; 25 Kumar (R11-23-20210309) 2012; 50 Abzug (R8-23-20210309) 2014; 68 Chou (R4-23-20210309) 2015; 94 31265664 - Medicine (Baltimore). 2016 Dec 02;95(48):e40dc |
| References_xml | – volume: 69 start-page: 7 year: 2015 ident: R26-23-20210309 article-title: Echovirus 30 meningitis epidemic followed by an outbreak-specific RT-qPCR publication-title: J Clin Virol doi: 10.1016/j.jcv.2015.05.012 – volume: 50 start-page: 3509 year: 2012 ident: R11-23-20210309 article-title: Molecular epidemiological study of enteroviruses associated with encephalitis in children from India publication-title: J Clin Microbiol doi: 10.1128/JCM.01483-12 – volume: 66 start-page: 939 year: 2009 ident: R3-23-20210309 article-title: Emerging viral infections of the central nervous system: Part 1 publication-title: Arch Neurol – volume: 16 start-page: 1780 year: 2010 ident: R12-23-20210309 article-title: Enterovirus 75 encephalitis in children, southern India publication-title: Emerg Infect Dis doi: 10.3201/eid1611.100672 – volume: 51 start-page: 142 year: 2011 ident: R23-23-20210309 article-title: An epidemic of encephalitis associated with human enterovirus B in Uttar Pradesh, India, 2008 publication-title: J Clin Virol doi: 10.1016/j.jcv.2011.02.011 – volume: 50 start-page: 817 year: 2014 ident: R13-23-20210309 article-title: Enterovirus infections are associated with white matter damage in neonates publication-title: J Paediatr Child Health doi: 10.1111/jpc.12656 – volume: 94 start-page: e707 year: 2015 ident: R4-23-20210309 article-title: Enterovirus encephalitis increases the risk of attention deficit hyperactivity disorder: a Taiwanese population-based case-control study publication-title: Medicine (Baltimore doi: 10.1097/MD.0000000000000707 – volume: 44 start-page: 207 year: 2012 ident: R21-23-20210309 article-title: Genome analysis of two type 6 echovirus (E6) strains recovered from sewage specimens in Greece in 2006 publication-title: Virus Genes doi: 10.1007/s11262-011-0688-3 – volume: 85 start-page: 1975 year: 2008 ident: R22-23-20210309 article-title: Molecular characterization of enteroviruses associated with neurological infections in Spain, 2008 publication-title: J Med Virol doi: 10.1002/jmv.23693 – volume: 12 start-page: 58 year: 2015 ident: R7-23-20210309 article-title: Epidemiology of childhood enterovirus infections in Hangzhou, China publication-title: Virol J doi: 10.1186/s12985-015-0294-4 – volume: 198 start-page: 1685 year: 2008 ident: R2-23-20210309 article-title: Enterovirus-associated encephalitis in the California encephalitis project, 1998–2005 publication-title: J Infect Dis doi: 10.1086/592988 – volume: 44 start-page: 2698 year: 2006 ident: R14-23-20210309 article-title: Sensitive, seminested PCR amplification of VP1 sequences for direct identification of all enterovirus serotypes from original clinical specimens publication-title: J Clin Microbiol doi: 10.1128/JCM.00542-06 – volume: 84 start-page: 116 year: 2016 ident: R10-23-20210309 article-title: Enterovirus meningitis in Tunisia (Monastir, Mahdia, 2011–2013): identification of virus variants cocirculating in France publication-title: Diagn Microbiol Infect Dis doi: 10.1016/j.diagmicrobio.2015.10.019 – volume: 222 start-page: 178 year: 2015 ident: R5-23-20210309 article-title: Epidemiological features of viral encephalitis in Cangzhou of China with use of multiplex RT-PCR for five RNA viruses publication-title: J Virol Methods doi: 10.1016/j.jviromet.2015.06.009 – volume: 87 start-page: 2033 year: 2015 ident: R24-23-20210309 article-title: Acute meningoencephalitis associated with echovirus 9 infection in Sri Lanka, 2009 publication-title: J Med Virol doi: 10.1002/jmv.24267 – volume: 70 start-page: 420 year: 2003 ident: R20-23-20210309 article-title: Molecular typing and epidemiology of enteroviruses identified from an outbreak of aseptic meningitis in Belgium during the summer of 2000 publication-title: J Med Virol doi: 10.1002/jmv.10412 – volume: 16 start-page: 399 year: 2016 ident: R15-23-20210309 article-title: Changes in enterovirus serotype constituent ratios altered the clinical features of infected children in Guangdong Province, China, from 2010 to 2013 publication-title: BMC Infect Dis doi: 10.1186/s12879-016-1690-0 – volume: 68 start-page: S108 year: 2014 ident: R8-23-20210309 article-title: The enteroviruses: problems in need of treatments publication-title: J Infect doi: 10.1016/j.jinf.2013.09.020 – volume: 10 start-page: e0144366 year: 2015 ident: R1-23-20210309 article-title: A population-based acute meningitis and encephalitis syndromes surveillance in Guangxi, China, May 2007–June 2012 publication-title: PLoS One doi: 10.1371/journal.pone.0144366 – volume: 8 start-page: e85023 year: 2013 ident: R6-23-20210309 article-title: Novel and predominant pathogen responsible for the enterovirus-associated encephalitis in eastern China publication-title: PLoS One doi: 10.1371/journal.pone.0085023 – volume: 31 start-page: 71 year: 2013 ident: R9-23-20210309 article-title: Enterovirus reverse transcriptase polymerase chain reaction assay incerebrospinal fluid: an essential tool inmeningitis management in childhood publication-title: Enferm Infecc Microbiol Clin doi: 10.1016/j.eimc.2012.07.007 – volume: 15 start-page: 1565 year: 2006 ident: R19-23-20210309 article-title: Beyond viruses: clinical profiles and etiologies associated with encephalitis publication-title: Clin Infect Dis doi: 10.1086/509330 – volume: 158 start-page: 2169 year: 2013 ident: R25-23-20210309 article-title: Recombination in human coxsackievirus B5 strains that caused an outbreak of viral encephalitis in Henan, China publication-title: Arch Virol doi: 10.1007/s00705-013-1709-4 – volume: 26 start-page: 282 year: 2005 ident: R18-23-20210309 article-title: Sequence analysis of Echovirus type 30 isolated from an aseptic meningitis outbreak in northern Jiangsu province in 2003 publication-title: Zhonghua Liu Xing Bing Xue Za Zhi – volume: 81 start-page: 2311 year: 2015 ident: R16-23-20210309 article-title: Elucidation of echovirus 30's origin and transmission during the 2012 aseptic meningitis outbreak in Guangdong, China, through continuing environmental surveillance publication-title: Appl Environ Microbiol doi: 10.1128/AEM.03200-14 – volume: 25 start-page: 409 year: 2011 ident: R17-23-20210309 article-title: Genetic analysis of echovirus 30 isolated from acute meningitis/encephalitis syndrome cases in Linyi city of Shandong province, China publication-title: Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi – reference: 31265664 - Medicine (Baltimore). 2016 Dec 02;95(48):e40dc |
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| Snippet | Enterovirus (EV) has over 100 serotypes of species A-D, which can cause various symptoms in infants. Enterovirus encephalitis (EVE) is serve disease with high... Enterovirus (EV) has over 100 serotypes of species A–D, which can cause various symptoms in infants. Enterovirus encephalitis (EVE) is serve disease with high... |
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| SubjectTerms | Adolescent Child Child, Preschool China Encephalitis, Viral - diagnosis Encephalitis, Viral - epidemiology Encephalitis, Viral - virology Enterovirus - genetics Enterovirus - isolation & purification Enterovirus Infections - diagnosis Enterovirus Infections - epidemiology Enterovirus Infections - virology Female Humans Infant Male Molecular Epidemiology Molecular Typing Observational Study Real-Time Polymerase Chain Reaction Retrospective Studies RNA, Viral - genetics RNA, Viral - isolation & purification |
| Title | Molecular epidemiological study of enteroviruses associated with encephalitis in children from Hangzhou, China |
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