Copper hypersensitivity

The world production of copper is steadily increasing. Although humans are widely exposed to copper‐containing items on the skin and mucosa, allergic reactions to copper are only infrequently reported. To review the chemistry, biology and accessible data to clarify the implications of copper hyperse...

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Published in	Contact dermatitis Vol. 71; no. 4; pp. 191 - 201
Main Authors	Fage, Simon W., Faurschou, Annesofie, Thyssen, Jacob P.
Format	Journal Article
Language	English
Published	Oxford, UK Blackwell Publishing Ltd 01.10.2014 Blackwell Wiley Subscription Services, Inc
Subjects	Allergic diseases Allergies Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases contact hypersensitivity Copper Copper - adverse effects Copper - chemistry Copper - immunology Cross Reactions dental dermatitis Drug Hypersensitivity - epidemiology Drug Hypersensitivity - etiology Drug Hypersensitivity - immunology Humans Immunopathology Ions Medical sciences Metals and various inorganic compounds Nickel - immunology Patch Tests Prevalence Skin allergic diseases. Stinging insect allergies Toxicology Human Immunopathology Allergy Skin disease dermatitis Contact dermatitis dental Transition metal Tooth Copper Bibliographic review Contact hypersensitivity copper contact hypersensitivity
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Abstract	The world production of copper is steadily increasing. Although humans are widely exposed to copper‐containing items on the skin and mucosa, allergic reactions to copper are only infrequently reported. To review the chemistry, biology and accessible data to clarify the implications of copper hypersensitivity, a database search of PubMed was performed with the following terms: copper, dermatitis, allergic contact dermatitis, contact hypersensitivity, contact sensitization, contact allergy, patch test, dental, IUD, epidemiology, clinical, and experimental. Human exposure to copper is relatively common. As a metal, it possesses many of the same qualities as nickel, which is a known strong sensitizer. Cumulative data on subjects with presumed related symptoms and/or suspected exposure showed that a weighted average of 3.8% had a positive patch test reaction to copper. We conclude that copper is a very weak sensitizer as compared with other metal compounds. However, in a few and selected cases, copper can result in clinically relevant allergic reactions.
AbstractList	The world production of copper is steadily increasing. Although humans are widely exposed to copper-containing items on the skin and mucosa, allergic reactions to copper are only infrequently reported. To review the chemistry, biology and accessible data to clarify the implications of copper hypersensitivity, a database search of PubMed was performed with the following terms: copper, dermatitis, allergic contact dermatitis, contact hypersensitivity, contact sensitization, contact allergy, patch test, dental, IUD, epidemiology, clinical, and experimental. Human exposure to copper is relatively common. As a metal, it possesses many of the same qualities as nickel, which is a known strong sensitizer. Cumulative data on subjects with presumed related symptoms and/or suspected exposure showed that a weighted average of 3.8% had a positive patch test reaction to copper. We conclude that copper is a very weak sensitizer as compared with other metal compounds. However, in a few and selected cases, copper can result in clinically relevant allergic reactions. [PUBLICATION ABSTRACT] The world production of copper is steadily increasing. Although humans are widely exposed to copper-containing items on the skin and mucosa, allergic reactions to copper are only infrequently reported. To review the chemistry, biology and accessible data to clarify the implications of copper hypersensitivity, a database search of PubMed was performed with the following terms: copper, dermatitis, allergic contact dermatitis, contact hypersensitivity, contact sensitization, contact allergy, patch test, dental, IUD, epidemiology, clinical, and experimental. Human exposure to copper is relatively common. As a metal, it possesses many of the same qualities as nickel, which is a known strong sensitizer. Cumulative data on subjects with presumed related symptoms and/or suspected exposure showed that a weighted average of 3.8% had a positive patch test reaction to copper. We conclude that copper is a very weak sensitizer as compared with other metal compounds. However, in a few and selected cases, copper can result in clinically relevant allergic reactions. The world production of copper is steadily increasing. Although humans are widely exposed to copper-containing items on the skin and mucosa, allergic reactions to copper are only infrequently reported. To review the chemistry, biology and accessible data to clarify the implications of copper hypersensitivity, a database search of PubMed was performed with the following terms: copper, dermatitis, allergic contact dermatitis, contact hypersensitivity, contact sensitization, contact allergy, patch test, dental, IUD, epidemiology, clinical, and experimental. Human exposure to copper is relatively common. As a metal, it possesses many of the same qualities as nickel, which is a known strong sensitizer. Cumulative data on subjects with presumed related symptoms and/or suspected exposure showed that a weighted average of 3.8% had a positive patch test reaction to copper. We conclude that copper is a very weak sensitizer as compared with other metal compounds. However, in a few and selected cases, copper can result in clinically relevant allergic reactions.The world production of copper is steadily increasing. Although humans are widely exposed to copper-containing items on the skin and mucosa, allergic reactions to copper are only infrequently reported. To review the chemistry, biology and accessible data to clarify the implications of copper hypersensitivity, a database search of PubMed was performed with the following terms: copper, dermatitis, allergic contact dermatitis, contact hypersensitivity, contact sensitization, contact allergy, patch test, dental, IUD, epidemiology, clinical, and experimental. Human exposure to copper is relatively common. As a metal, it possesses many of the same qualities as nickel, which is a known strong sensitizer. Cumulative data on subjects with presumed related symptoms and/or suspected exposure showed that a weighted average of 3.8% had a positive patch test reaction to copper. We conclude that copper is a very weak sensitizer as compared with other metal compounds. However, in a few and selected cases, copper can result in clinically relevant allergic reactions.
Author	Fage, Simon W. Faurschou, Annesofie Thyssen, Jacob P.
Author_xml	– sequence: 1 givenname: Simon W. surname: Fage fullname: Fage, Simon W. organization: Department of Dermato-Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, 2900 Hellerup, Denmark – sequence: 2 givenname: Annesofie surname: Faurschou fullname: Faurschou, Annesofie organization: Department of Dermato-Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, 2900 Hellerup, Denmark – sequence: 3 givenname: Jacob P. surname: Thyssen fullname: Thyssen, Jacob P. email: jacpth01@geh.regionh.dk organization: Department of Dermato-Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, 2900 Hellerup, Denmark
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Keywords	Human Immunopathology Allergy Skin disease dermatitis Contact dermatitis dental Transition metal Tooth Copper Bibliographic review Contact hypersensitivity copper contact hypersensitivity
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Oral lichen planus and sensitization to copp 2010; 11 1993; 69 1993; 29 1993; 28 2013; 68 1991; 10 1983; 1 2000; 43 1968; 125 1983; 9 2008; 5 2003; 18 1999; 41 2007; 73 2001; 44 2001; 45 1996; 35 2009; 49 1996; 34 2003; 197 1994; 102 2002; 47 1977; 39 2000; 12 1995; 25 1979; 5 2003; 48 2011; 66 2008; 68 1969; 49 2001; 12 1972; 12 1990; 176 1992; 89 1972; 106 1994; 30 1995; 160 1968; 98 1985; 13 1979; 19 1955; 25 2012 1988; 18 2011 1988; 19 2006; 54 1997; 26 1999; 27 1981; 7 2013; 93 1996; 51 2003 2011; 38 1987; 17 1992; 30 1998; 38 1998; 39 1980; 14 2004; 50 1989; 97 2007; 151 1991; 24 2013; 34 1978; 41 1997; 36 1977; 3 1995; 105 2005; 209 1980; 60 2013 2001; 34 1998; 6 1992; 67 1976; 15 1992; 62 e_1_2_11_70_1 e_1_2_11_72_1 e_1_2_11_91_1 e_1_2_11_32_1 e_1_2_11_55_1 e_1_2_11_78_1 e_1_2_11_30_1 Dhir G G (e_1_2_11_51_1) 1977; 39 e_1_2_11_57_1 e_1_2_11_36_1 e_1_2_11_74_1 e_1_2_11_34_1 e_1_2_11_53_1 e_1_2_11_76_1 e_1_2_11_11_1 Frentz G (e_1_2_11_19_1) 1980; 60 e_1_2_11_29_1 e_1_2_11_6_1 e_1_2_11_27_1 e_1_2_11_4_1 e_1_2_11_48_1 e_1_2_11_2_1 Emsley J (e_1_2_11_3_1) 2003 e_1_2_11_83_1 Dry J (e_1_2_11_67_1) 1978; 41 e_1_2_11_60_1 e_1_2_11_81_1 e_1_2_11_20_1 e_1_2_11_45_1 Laubstein B (e_1_2_11_93_1) 1990; 176 Frykholm K O (e_1_2_11_17_1) 1969; 49 e_1_2_11_47_1 e_1_2_11_68_1 e_1_2_11_89_1 e_1_2_11_24_1 e_1_2_11_41_1 e_1_2_11_62_1 e_1_2_11_87_1 Black H (e_1_2_11_39_1) 1972; 12 e_1_2_11_8_1 e_1_2_11_22_1 e_1_2_11_43_1 e_1_2_11_64_1 e_1_2_11_85_1 Reid D J (e_1_2_11_16_1) 1968; 125 e_1_2_11_15_1 e_1_2_11_59_1 e_1_2_11_38_1 e_1_2_11_94_1 Vilaplana J (e_1_2_11_13_1) 2000; 43 e_1_2_11_50_1 e_1_2_11_71_1 e_1_2_11_92_1 Uveges R E (e_1_2_11_66_1) 1995; 160 e_1_2_11_90_1 e_1_2_11_10_1 e_1_2_11_31_1 e_1_2_11_77_1 e_1_2_11_58_1 e_1_2_11_79_1 e_1_2_11_14_1 e_1_2_11_35_1 e_1_2_11_52_1 e_1_2_11_73_1 e_1_2_11_12_1 e_1_2_11_33_1 e_1_2_11_54_1 e_1_2_11_75_1 e_1_2_11_7_1 e_1_2_11_28_1 e_1_2_11_5_1 e_1_2_11_26_1 e_1_2_11_49_1 Barranco V P (e_1_2_11_21_1) 1972; 106 e_1_2_11_82_1 e_1_2_11_61_1 e_1_2_11_80_1 e_1_2_11_44_1 e_1_2_11_46_1 e_1_2_11_69_1 e_1_2_11_88_1 e_1_2_11_25_1 e_1_2_11_40_1 e_1_2_11_63_1 e_1_2_11_86_1 e_1_2_11_9_1 e_1_2_11_23_1 e_1_2_11_42_1 e_1_2_11_65_1 e_1_2_11_84_1 e_1_2_11_18_1 e_1_2_11_37_1 Stenman E (e_1_2_11_56_1) 1989; 97
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Snippet	The world production of copper is steadily increasing. Although humans are widely exposed to copper‐containing items on the skin and mucosa, allergic reactions... The world production of copper is steadily increasing. Although humans are widely exposed to copper-containing items on the skin and mucosa, allergic reactions...
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SubjectTerms	Allergic diseases Allergies Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases contact hypersensitivity Copper Copper - adverse effects Copper - chemistry Copper - immunology Cross Reactions dental dermatitis Drug Hypersensitivity - epidemiology Drug Hypersensitivity - etiology Drug Hypersensitivity - immunology Humans Immunopathology Ions Medical sciences Metals and various inorganic compounds Nickel - immunology Patch Tests Prevalence Skin allergic diseases. Stinging insect allergies Toxicology
Title	Copper hypersensitivity
URI	https://api.istex.fr/ark:/67375/WNG-DMTGWJH6-3/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fcod.12273 https://www.ncbi.nlm.nih.gov/pubmed/25098945 https://www.proquest.com/docview/1562585239 https://www.proquest.com/docview/1563988412 https://www.proquest.com/docview/1611615644
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