Translocation of Sphingosine Kinase 1 to the Plasma Membrane Is Mediated by Calcium- and Integrin-binding Protein 1

• Published in: The Journal of biological chemistry Vol. 285; no. 1; pp. 483 - 492
• Main Authors: Jarman, Kate E., Moretti, Paul A.B., Zebol, Julia R., Pitson, Stuart M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2010; American Society for Biochemistry and Molecular Biology
• Subjects: Apoptosis - drug effects; Binding Sites; Calcium - metabolism; Calcium-Binding Proteins - metabolism; Calcium/Binding Proteins; Calcium/Cellular Regulation; Calmodulin - metabolism; Cell Line, Tumor; Cell Membrane - drug effects; Cell Membrane - enzymology; Enzymes/Kinase; Enzymes/Lipid; Gene Knockdown Techniques; Genes, Dominant - genetics; Humans; Lipid/Sphingolipids; Mechanisms of Signal Transduction; Myristic Acid - metabolism; NF-kappa B - metabolism; Phosphotransferases (Alcohol Group Acceptor) - metabolism; Protein Binding - drug effects; Protein Transport - drug effects; Protein/Protein-Protein Interactions; Protein/Translocation; Tumor Necrosis Factor-alpha - pharmacology; Protein/Protein-Protein Interactions; Enzymes/Kinase; Enzymes/Lipid; Lipid/Sphingolipids; Calcium/Cellular Regulation; Calcium/Binding Proteins; Protein/Translocation

SK1 (sphingosine kinase 1) plays an important role in many aspects of cellular regulation. Most notably, elevated cellular SK1 activity leads to increased cell proliferation, protection from apoptosis, and induction of neoplastic transformation. We have previously shown that translocation of SK1 fro...