Oncogenic herpesvirus KSHV triggers hallmarks of alternative lengthening of telomeres

To achieve replicative immortality, cancer cells must activate telomere maintenance mechanisms to prevent telomere shortening. ~85% of cancers circumvent telomeric attrition by re-expressing telomerase, while the remaining ~15% of cancers induce alternative lengthening of telomeres (ALT), which reli...

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Bibliographic Details
Published inNature communications Vol. 12; no. 1; pp. 512 - 11
Main Authors Lippert, Timothy P., Marzec, Paulina, Idilli, Aurora I., Sarek, Grzegorz, Vancevska, Aleksandra, Bower, Mark, Farrell, Paul J., Ojala, Päivi M., Feldhahn, Niklas, Boulton, Simon J.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 21.01.2021
Nature Publishing Group
Nature Portfolio
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