A tubulin alpha 8 mouse knockout model indicates a likely role in spermatogenesis but not in brain development

• Published in: PloS one Vol. 12; no. 4; p. e0174264
• Main Authors: Diggle, Christine P, Martinez-Garay, Isabel, Molnar, Zoltan, Brinkworth, Martin H, White, Ed, Fowler, Ewan, Hughes, Ruth, Hayward, Bruce E, Carr, Ian M, Watson, Christopher M, Crinnion, Laura, Asipu, Aruna, Woodman, Ben, Coletta, P Louise, Markham, Alexander F, Dear, T Neil, Bonthron, David T, Peckham, Michelle, Morrison, Ewan E, Sheridan, Eamonn
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.04.2017; Public Library of Science (PLoS)
• Subjects: Acetylation; Acetyltransferase; Actin; Adhesion; Adhesive bonding; Alanine; Amino acid sequence; Amino acids; Analysis; Anatomy; Androgens; Animals; Axon guidance; Biology; Biology and Life Sciences; Biomedical materials; Brain; Brain - embryology; Carbendazim; Cell adhesion molecules; Cerebrum; Coding; Colchicine; Cyclin-dependent kinase; Cyclin-dependent kinase 5; Cytoskeleton; Dominant traits; Exome; Exons; Fragmentation; Functional analysis; Gene expression; Genetics; Homozygote; Hypoplasia; Infertility; Isoforms; Libraries; Medical research; Medicine; Medicine and Health Sciences; Mice; Mice, Knockout; Microtubules; Mitosis; Modulation; Mutation; Neurobiology; Pharmacology; Physiological aspects; Physiology; Position (location); Post-translational modifications; Protection and preservation; Protein expression; Proteins; Rats; Research and Analysis Methods; Rodents; Spermatogenesis; Spermatogenesis - genetics; Stability; Synteny; Tissues; Tubulin; Tubulin - genetics; United Kingdom

Tubulin alpha 8 (Tuba8) is the most divergent member of the highly conserved alpha tubulin family, and uniquely lacks two key post-translational modification sites. It is abundantly expressed in testis and muscle, with lower levels in the brain. We previously identified homozygous hypomorphic TUBA8...