Characterization of In Vitro Expanded Virus-Specific T cells for Adoptive Immunotherapy against Virus Infection

• Published in: Japanese Journal of Infectious Diseases Vol. 71; no. 2; pp. 122 - 128
• Main Authors: Ono, Toshiaki, Fujita, Yuriko, Matano, Tetsuro, Takahashi, Satoshi, Morio, Tomohiro, Kawana-Tachikawa, Ai
• Format: Journal Article
• Language: English
• Published: Japan National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee 2018; Japan Science and Technology Agency
• Subjects: Adoptive immunotherapy; Adoptive transfer; BZLF1 protein; CD4 antigen; CD8 antigen; Cryopreservation; Cytomegalovirus; ELISpot; Epitope mapping; Epstein-Barr virus; HLA restriction; IE1 protein; Immunocompromised hosts; Immunotherapy; Interleukin 7; Leukocytes (mononuclear); Lymphocytes; Lymphocytes T; Peptide mapping; Peptides; Peripheral blood mononuclear cells; Pp65 protein; Predictions; Proteins; T cell adoptive transfer; T cell receptors; virus-specific T cells; Viruses; virus-specific T cells; HLA restriction; T cell adoptive transfer; ELISpot; epitope mapping

Adoptive transfer of virus-specific T cells has emerged as a promising therapeutic approach for treatment of virus infections in immunocompromised hosts. Characterization of virus-specific T cells provides essential information about the curative mechanism of the treatment. In this study, we develop...