Disrupting Hypothalamic Glucocorticoid Receptors Causes HPA Axis Hyperactivity and Excess Adiposity

• Published in: Molecular endocrinology (Baltimore, Md.) Vol. 27; no. 10; pp. 1655 - 1665
• Main Authors: Laryea, Gloria, Schütz, Günther, Muglia, Louis J
• Format: Journal Article
• Language: English
• Published: Chevy Chase, MD Endocrine Society 01.10.2013; Oxford University Press
• Subjects: Adiposity; Animals; Attention deficit disorders. Hyperactivity; Biological and medical sciences; Child clinical studies; Corticosterone - blood; Female; Hypothalamo-Hypophyseal System - metabolism; Locomotion; Male; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Neurons - metabolism; Obesity - metabolism; Original Research; Paraventricular Hypothalamic Nucleus - metabolism; Paraventricular Hypothalamic Nucleus - pathology; Pituitary-Adrenal System - metabolism; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Receptors, Glucocorticoid - genetics; Receptors, Glucocorticoid - metabolism; Hypothalamus; Adiposity; Hyperactivity; Central nervous system; Glucocorticoid receptor; Encephalon

The glucocorticoid receptor (GR) regulates hypothalamic-pituitary-adrenal (HPA) axis activity during the stress response. The paraventricular nucleus (PVN) is a major site of negative feedback to coordinate the degree of the HPA axis activity with the magnitude of the exposed stressor. To define the...