Recombinant adenoassociated virus 2/5-mediated gene transfer is reduced in the aged rat midbrain

• Published in: Neurobiology of aging Vol. 36; no. 2; pp. 1110 - 1120
• Main Authors: Polinski, Nicole K., Gombash, Sara E., Manfredsson, Fredric P., Lipton, Jack W., Kemp, Christopher J., Cole-Strauss, Allyson, Kanaan, Nicholas M., Steece-Collier, Kathy, Kuhn, Nathan C., Wohlgenant, Susan L., Sortwell, Caryl E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2015
• Subjects: Adeno-associated virus 2; Aging - metabolism; Aging - pathology; Animals; Dependovirus - genetics; Gene Expression Regulation, Developmental; Gene Transfer Techniques; Genetic Vectors - genetics; Immunohistochemistry; Internal Medicine; Male; Mesencephalon - metabolism; Neurology; Parkinson's disease; Rats, Inbred F344; Rats, Sprague-Dawley; Recombination, Genetic; RNA, Messenger - analysis; RNA, Messenger - genetics; Striatum; Substantia nigra; Transduction; Viral vector; Striatum; Transduction; Parkinson's disease; Viral vector; Substantia nigra

Clinical trials are examining the efficacy of viral vector-mediated gene delivery for treating Parkinson's disease. Although viral vector strategies have been successful in preclinical studies, to date clinical trials have disappointed. This may be because of the fact that preclinical studies f...